INT102637

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 2.82
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) nuclear chromosome (Vdr) aging (Vdr)
cell morphogenesis (Vdr) nucleus (Vdr) DNA binding (Vdr)
Anatomy Link Frequency
smooth muscle cells 2
parathyroid 1
Vdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 10 96.36 Very High Very High Very High
member 8 1 86.88 High High
Pain 6 25.52 Quite Low
fibrosis 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 140 99.78 Very High Very High Very High
Atherosclerosis 15 99.60 Very High Very High Very High
Hypercalcemia 169 96.48 Very High Very High Very High
Calcification 25 93.76 High High
Osteoporosis 2 92.00 High High
Hyperplasia 10 74.48 Quite High
Rickets 1 60.32 Quite High
Renal Disease 15 52.72 Quite High
Myalgia 1 26.08 Quite Low
Hip Fractures 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This compound (VDRM2) potently induced Retinoid X Receptor alpha (RXR)-VDR heterodimerization (EC(50) = 7.1 +/- 1.6 nM) and induced osteocalcin promoter activity (EC(50) = 1.9 +/- 1.6 nM).
Positive_regulation (induced) of VDR
1) Confidence 0.48 Published 2010 Journal J. Bone Miner. Res. Section Abstract Doc Link 20200930 Disease Relevance 0.31 Pain Relevance 0.09
Activation of the VDR stimulates the protective effects of type 2 helper T (Th2) cells through the induction of cytokines such as IL4 and IL10 (Boonstra et al 2001; Barrat et al 2002).
Positive_regulation (Activation) of VDR associated with cytokine
2) Confidence 0.46 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.59 Pain Relevance 0.05
Activation of the vitamin D receptor (VDR) on vascular smooth muscle cells has been found to regulate the synthesis of type 1 collagen, core binding factor alpha and bone morphogenic protein 2 – all of which contribute to the development of arterial calcification and mineralization (Virdi et al 1998; Bellows et al 1999; Drissi et al 2002).
Positive_regulation (Activation) of VDR in smooth muscle cells associated with calcification
3) Confidence 0.46 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.44 Pain Relevance 0.03
Activation of the vitamin D receptor (VDR) on vascular smooth muscle cells has been found to regulate the synthesis of type 1 collagen, core binding factor alpha and bone morphogenic protein 2 – all of which contribute to the development of arterial calcification and mineralization (Virdi et al 1998; Bellows et al 1999; Drissi et al 2002).
Positive_regulation (Activation) of vitamin D receptor in smooth muscle cells associated with calcification
4) Confidence 0.46 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.44 Pain Relevance 0.03
Analogs of active vitamin D were developed to inhibit parathyroid secretion while minimizing the effects of vitamin D receptor activation elsewhere.
Positive_regulation (activation) of vitamin D receptor in parathyroid
5) Confidence 0.33 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.27 Pain Relevance 0
Calcitriol deficiency in renal failure decreases VDR activation and may thus play a direct role in mediating cardiovascular complications.


Positive_regulation (activation) of VDR associated with chronic renal failure
6) Confidence 0.31 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.60 Pain Relevance 0.04
Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR).
Positive_regulation (mediated) of vitamin D receptor
7) Confidence 0.15 Published 2002 Journal Osteoporos Int Section Abstract Doc Link 11991436 Disease Relevance 0.15 Pain Relevance 0

General Comments

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