INT102639

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 37
Disease Relevance 18.05
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
Anatomy Link Frequency
macrophages 2
monocytes 2
muscle 2
spinal 1
skeletal muscle tissue 1
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
antiepileptic Drug 23 99.34 Very High Very High Very High
Chronic low back pain 1 99.18 Very High Very High Very High
Multiple sclerosis 133 98.48 Very High Very High Very High
Bile 9 95.92 Very High Very High Very High
Pain 108 94.20 High High
Lasting pain 35 88.08 High High
carbamazepine 60 86.56 High High
cytokine 109 77.68 Quite High
palliative 4 74.80 Quite High
Lamotrigine 3 70.28 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 209 100.00 Very High Very High Very High
Hypophosphatemia 9 99.88 Very High Very High Very High
Mycobacterial Infection 98 99.84 Very High Very High Very High
Osteogenic Sarcomas 82 99.84 Very High Very High Very High
Intervertebral Disk Degeneration 78 99.72 Very High Very High Very High
Hypocalcemia 25 99.52 Very High Very High Very High
Apoptosis 69 99.46 Very High Very High Very High
Skin Cancer 67 99.28 Very High Very High Very High
Low Back Pain 11 99.18 Very High Very High Very High
Disease 252 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to SkMel5 cells, treatment of MeWo cells with calcitriol resulted in a dose-dependent increase in mRNA for VDR and 24-OHase as well as in a suppression of cell proliferation (up to approximately 50%).
Positive_regulation (increase) of VDR in MeWo
1) Confidence 0.69 Published 2004 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15225804 Disease Relevance 0.56 Pain Relevance 0.07
Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR).
Positive_regulation (mediated) of VDR
2) Confidence 0.47 Published 2002 Journal Osteoporos Int Section Abstract Doc Link 11991436 Disease Relevance 0.15 Pain Relevance 0
The effect of antiepileptic drugs on bone mineral density is also mediated by Vitamin D receptor (VDR) gene, an important regulator of osteoclastic activity [17].
Positive_regulation (mediated) of VDR associated with osteoporosis and antiepileptic drug
3) Confidence 0.46 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2919461 Disease Relevance 0.56 Pain Relevance 0.20
In a separate report involving chronic low back pain patients, 83% had low vitamin D status; following vitamin D therapy, 95% of these patients showed improvement in their symptoms [14].
Positive_regulation (following) of vitamin D associated with low back pain and chronic low back pain
4) Confidence 0.44 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3010688 Disease Relevance 0.82 Pain Relevance 0.57
Recombinant DREAM, glutathione S-transferase (GST)-fused VDR and RXR (50–100 ng) and in vitro translated RXR, VDR and RAR were used in the assays with labeled DRE, DR3 and DR5 oligonucleotides as described previously (30).
Positive_regulation (fused) of VDR
5) Confidence 0.42 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
This particular arrangement permits RAR and VDR upon ligand binding to undergo conformational changes that facilitate the recruitment of coactivator complexes.
Positive_regulation (permits) of VDR
6) Confidence 0.42 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Molecular mimicry of naturally phosphorylated human PRL at the major phosphorylation site S179, S179D (PRL), sensitizes relatively vitamin D-insensitive prostate cancer cells DU-145 and PC3 to calcitriol-mediated anti-proliferative effect and apoptosis, which is associated with increased VDR and p21 expression 63.
Positive_regulation (increased) of VDR associated with prostate cancer and apoptosis
7) Confidence 0.40 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.51 Pain Relevance 0
Therefore, a combination of reduced binding affinity and abnormal association with coactivators could explain the lack of transcriptional activity of the RXR/VDR heterodimer upon binding to the DRE.
Positive_regulation (activity) of VDR
8) Confidence 0.39 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
SCC-VII and a calcitriol-resistant variant SCC (SCC-DR), generated by continuous culturing of SCC cells in calcitriol-containing media and has non-inducible VDR, are resistant to cisplatin 19.
Positive_regulation (inducible) of VDR associated with skin cancer
9) Confidence 0.37 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.85 Pain Relevance 0
After transfection, the cells were incubated for 24–36 h in the presence and absence of 100 nM vitamin D (Vit.D) or 1 ?
Positive_regulation (incubated) of vitamin D
10) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
However, DREAM was recruited to the VDRE promoter region in cells incubated with vitamin D and to the RARE promoter region in RA-treated cells (compare lanes 5 and 6).
Positive_regulation (incubated) of vitamin D associated with rheumatoid arthritis
11) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.37 Pain Relevance 0
One explanation is that the increase of vitamin D results from sunlight exerting a protective effect [91-93].
Positive_regulation (increase) of vitamin D
12) Confidence 0.35 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 1.02 Pain Relevance 0.43
Increasing vitamin D levels through oral supplementation or sunlight exposure is vital in the management of these conditions.
Positive_regulation (Increasing) of vitamin D
13) Confidence 0.35 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 1.17 Pain Relevance 0.10
Results obtained were corrected by the input and are expressed as fold induction of vitamin D or RA-treated versus untreated cells.


Positive_regulation (induction) of vitamin D associated with rheumatoid arthritis
14) Confidence 0.34 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.10 Pain Relevance 0
In parallel with the increase in acetylated H4 histone and DREAM, RA and vitamin D also caused the recruitment of the coactivator to the RARE or VDRE p21Cip1 promoter regions (Figure 5D).


Positive_regulation (increase) of vitamin D associated with rheumatoid arthritis
15) Confidence 0.34 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.39 Pain Relevance 0
Vitamin D requirements differ in children and adults so that a comparison of vitamin D levels between populations of children and adults would not be instructive.
Positive_regulation (requirements) of Vitamin D
16) Confidence 0.33 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778183 Disease Relevance 0.51 Pain Relevance 0.45
Interestingly, it has been reported that the upregulation of VDR in OS cell lines is dependent on the tumor suppressor BRCA1 [202].
Positive_regulation (upregulation) of VDR associated with cancer and osteogenic sarcomas
17) Confidence 0.30 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.64 Pain Relevance 0
VDR activation is linked to more than 60 genes promoting pro-differentiation, antiproliferation, and apoptotic activity on prostate cancer cells.34,35 Calcitriol has been shown to potentiate the effect of cytotoxic therapy when combined with taxanes.
Positive_regulation (activation) of VDR associated with prostate cancer and apoptosis
18) Confidence 0.28 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.98 Pain Relevance 0.08
These markers may be increased even in the presence of normal vitamin D and PTH levels [47].
Positive_regulation (increased) of vitamin D
19) Confidence 0.27 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.21 Pain Relevance 0.04
A level of 25-hydroxyvitamin D of 21 to 29 ng per millilitre (52 to 72 nmol per litre) is considered as an insufficiency of vitamin D, and sufficient vitamin D should reach a level of 30 ng per millilitre or greater [17].
Positive_regulation (insufficiency) of vitamin D
20) Confidence 0.25 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.34 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox