INT102642

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr)
cytoplasm (Gsr)
Gsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 10 69.20 Quite High
cINOD 2 46.44 Quite Low
cytokine 1 39.76 Quite Low
Inflammation 1 39.36 Quite Low
agonist 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Toxicity 7 98.00 Very High Very High Very High
Stress 10 83.60 Quite High
Injury 2 63.52 Quite High
Apoptosis 2 62.28 Quite High
Adhesions 1 42.40 Quite Low
INFLAMMATION 2 39.36 Quite Low
Enteropathy 1 35.00 Quite Low
Hypertrophy 8 10.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite inhibiting cyclooxygenase activity, the attenuation of (S)-(+)-ketoprofen-induced intestinal toxicity could be correlated with a reduced oxidative damage characterized not only by a lack of changes in glutathione reductase activity and glutathione levels but also by an absence of up-regulation of tumor necrosis factor-alpha production in intestinal mucosa.
Positive_regulation (up-regulation) of Gene_expression (production) of glutathione reductase associated with necrosis, toxicity and cancer
1) Confidence 0.25 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 11991627 Disease Relevance 0.80 Pain Relevance 0
Glutathione reductase expression was increased for animals in the mid and high dose groups at all time points.
Positive_regulation (increased) of Gene_expression (expression) of Glutathione reductase
2) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.08 Pain Relevance 0.03
Glutamine cysteine ligase and glutathione reductase expression were increased whereas glutamine synthetase expression was decreased (figure 5C, table 3).
Positive_regulation (increased) of Gene_expression (expression) of glutathione reductase
3) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.19 Pain Relevance 0

General Comments

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