INT102646

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 4.37
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
chondrocytes 5
fibroblasts 1
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 4 100.00 Very High Very High Very High
Osteoarthritis 721 99.60 Very High Very High Very High
cytokine 56 99.00 Very High Very High Very High
cINOD 5 98.76 Very High Very High Very High
chemokine 5 79.48 Quite High
Arthritis 56 67.36 Quite High
rheumatoid arthritis 28 55.60 Quite High
Inflammation 112 48.32 Quite Low
Pain 14 44.08 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 728 99.60 Very High Very High Very High
Stress 7 98.36 Very High Very High Very High
Colorectal Cancer 4 96.84 Very High Very High Very High
Apoptosis 11 91.16 High High
INFLAMMATION 100 89.64 High High
Targeted Disruption 21 87.60 High High
Experimental Arthritis 7 67.36 Quite High
Arthritis 63 66.80 Quite High
Rheumatoid Arthritis 28 55.60 Quite High
Retinal Diseases 1 47.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced activation of MKK3 and MKK6 in human OA chondrocytes
Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
1) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30
-induced activation of MKK3 and MKK6 in primary human OA chondrocytes.
Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
2) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.49 Pain Relevance 0.24
-induced activation of MKK3 and MKK6 in human OA chondrocytes, cells were pretreated with PE (6.25 to 100 ?
Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
3) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.71 Pain Relevance 0.33
-induced phosphorylation/activation of both MKK3 and MKK6, but the effect was more pronounced on MKK3 in primary human OA chondrocytes.
Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
4) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.53 Pain Relevance 0.24
This suggests that substrate selectivity might contribute to the distinct functional profiles of MKK activation.
Positive_regulation (activation) of MKK
5) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.33 Pain Relevance 0.17
For instance, MKK6 is the major activator of p38-MAPK in cells exposed to osmotic stress [13] and MKK3 is required for full activation of p38-MAPK in murine embryonic fibroblasts [38].
Positive_regulation (activator) of MKK6 in fibroblasts associated with stress
6) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30
Expression and activation of MKK3 and MKK6 in human OA chondrocytes
Positive_regulation (activation) of MKK6 in chondrocytes associated with osteoarthritis
7) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.43 Pain Relevance 0.22
These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB, PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells.
Positive_regulation (activation) of MEK associated with dexamethasone
8) Confidence 0.11 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.38
These results point to a key role for the MEK/ERK signalling pathway in mediating the effects of a COX-2-selective NSAID on colorectal carcinoma cells.
Positive_regulation (role) of MEK associated with colorectal cancer and cinod
9) Confidence 0.08 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.58 Pain Relevance 0.27

General Comments

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