INT10265

Context Info Confidence 0.33 First Reported 1984 Last Reported 2005 Negated 4 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 0.35 Pain Relevance 2.91

extracellular space (Sst) extracellular region (Sst)

Anatomy Link Frequency pancreas 2 posterior 2 Sst (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 44 100.00 Morphine 5 96.88 tetrodotoxin 10 96.20 Central nervous system 1 91.60 antagonist 1 89.36 c fibre 2 71.60 GABAergic 1 27.04 nociceptor 3 25.00 Migraine 1 25.00 Cluster headache 1 25.00

Disease Link Frequency Relevance Heat Nociception 4 99.32 Hyperinsulinism 2 83.04 Headache 1 5.00 Cluster Headache 1 5.00 Primary Headache Disorders 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Non-adrenergic non-cholinergic effects do not participate in regulation of glucagon and somatostatin secretion under the conditions employed.

Neg (not) Regulation (participate) of Regulation (regulation) of somatostatin associated with somatostatin

1) Confidence 0.33 Published 1992 Journal Diabetologia Section Abstract Doc Link 1478364 Disease Relevance 0 Pain Relevance 0.31

As shown previously, atropine had an identical effect on gastrin and somatostatin responses to transmural electrical stimulation of the antral region.

Regulation (effect) of Regulation (effect) of somatostatin associated with somatostatin

2) Confidence 0.31 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.32

We studied the effects of somatostatin receptor modulation in the posterior hypothalamic area (PH) of the rat on dural nociceptive input.

Regulation (effects) of Regulation (modulation) of somatostatin in posterior associated with nociception and somatostatin

3) Confidence 0.25 Published 2005 Journal Pain Section Abstract Doc Link 16043293 Disease Relevance 0.27 Pain Relevance 0.61

This shows that morphine induces the release of insulin, glucagon and somatostatin from pancreas in a dose-dependent way, and that release of insulin and glucagon is not primarily affected by regulation of somatostatin levels.

Neg (not) Regulation (affected) of Regulation (regulation) of somatostatin in pancreas associated with somatostatin and morphine

4) Confidence 0.24 Published 1994 Journal Res Exp Med (Berl) Section Abstract Doc Link 7800932 Disease Relevance 0 Pain Relevance 0.65

Atropine partially inhibited the gastrin response (34 +/- 6%) but had no effect on the somatostatin response.

Neg (no) Regulation (effect) of Regulation (response) of somatostatin associated with somatostatin

5) Confidence 0.24 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.47

In contrast the combined adrenergic and cholinergic blockade with atropine, phentolamine and propranolol (10(-5) mol/l) did not modify the insulin, glucagon and somatostatin response.

Neg (not) Regulation (modify) of Neg (not) Regulation (response) of somatostatin associated with somatostatin

6) Confidence 0.20 Published 1992 Journal Diabetologia Section Abstract Doc Link 1478364 Disease Relevance 0.08 Pain Relevance 0.56

General Comments

This test has worked.