INT102654

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.53
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pln) protein complex (Pln)
Anatomy Link Frequency
T-cell 2
muscle 1
Pln (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 108 99.88 Very High Very High Very High
cINOD 27 84.84 Quite High
Pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hemolytic Anemia 9 91.64 High High
Hepatotoxicity 9 90.36 High High
Anaphylaxis 9 89.16 High High
Hypertrophy 30 89.00 High High
Hypersensitivity 18 87.08 High High
Targeted Disruption 28 82.44 Quite High
INFLAMMATION 9 80.84 Quite High
Stress 2 28.16 Quite Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Dislocations 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In BALB/c mice, diclofenac caused dose-dependent increases in PLN weight and PLN cellularity in the direct PLNA; 0.25 mg was non-immunostimulating whereas 0.50-1.00 mg caused a significant PLN reaction.
Positive_regulation (increases) of PLN associated with diclofenac
1) Confidence 0.48 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.52 Pain Relevance 0.53
Collectively, these data suggest that diclofenac: (i) induces a T-cell-dependent direct PLN reaction that; (ii) provides non-cognate help for IgG AFC production when co-injected with TNP-Ficoll, possibly through the formation of neo-antigens; and (iii) possesses intrinsic adjuvant activity that selectively induces IL-4 mediated production of IgG(1) and IgE against co-injected TNP-OVA.
Positive_regulation (induces) of PLN in T-cell associated with diclofenac
2) Confidence 0.40 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.31
When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.
Positive_regulation (increases) of PLN associated with diclofenac
3) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.38 Pain Relevance 0.53
When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.
Positive_regulation (increases) of PLN associated with diclofenac
4) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.38 Pain Relevance 0.53
As expected, phenobarbital (1.00 mg) failed to cause an increase in PLN cellularity or induce AFCs in the PLN.
Neg (failed) Positive_regulation (induce) of PLN
5) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.16 Pain Relevance 0.40
As expected, phenobarbital (1.00 mg) failed to cause an increase in PLN cellularity or induce AFCs in the PLN.
Positive_regulation (increase) of PLN
6) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.21 Pain Relevance 0.40
In the direct PLNA, diclofenac also increased the percent of T cells in the PLN with activated phenotypes (CD44(high)CD62L(low) and CD44(high)CD62L(high)).
Positive_regulation (increased) of PLN in T cells associated with diclofenac
7) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.48 Pain Relevance 0.55
Streptozotocin (1.00 mg) caused significant increases in PLN cellularity, IgM AFCs, and selectively induced IgG(2a) and IgG(2b) AFCs against TNP-OVA.
Positive_regulation (increases) of PLN
8) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.10 Pain Relevance 0.40
In BALB/c mice, diclofenac caused dose-dependent increases in PLN weight and PLN cellularity in the direct PLNA; 0.25 mg was non-immunostimulating whereas 0.50-1.00 mg caused a significant PLN reaction.
Positive_regulation (increases) of PLN associated with diclofenac
9) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.52 Pain Relevance 0.54
While the increase in PI3K/PKB activity in the overloaded PLN muscle did not lead to an increase in muscle growth, it could have led to alterations in phenotype that were not measured.
Positive_regulation (increase) of PLN in muscle
10) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.37 Pain Relevance 0
Specifically, the fact that S6K1 Thr389 phosphorylation is elevated in the PLN in parallel with increased PKB Thr308 phosphorylation suggests that the inhibitory effect of AMPK on mTORC1 is not the only mechanism at work.
Positive_regulation (elevated) of PLN
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.39 Pain Relevance 0

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