INT102655

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 12 99.60 Very High Very High Very High
cINOD 3 61.76 Quite High
ischemia 20 58.68 Quite High
Inflammation 12 57.04 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 72.20 Quite High
Autoimmune Hemolytic Anemia 1 68.56 Quite High
Hepatotoxicity 1 67.28 Quite High
Anaphylaxis 1 66.08 Quite High
Hypersensitivity 2 64.00 Quite High
Cv Unclassified Under Development 16 58.68 Quite High
INFLAMMATION 13 57.76 Quite High
Injury 37 55.36 Quite High
Coronary Artery Disease 7 50.00 Quite Low
Myocarditis 2 44.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.
Positive_regulation (increases) of Positive_regulation (induced) of IgM associated with diclofenac
1) Confidence 0.32 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.38 Pain Relevance 0.56
While the lectin and alternative complement pathways are historically known to activate complement in an antibody independent manner, our group recently demonstrated that MBL also interacts with IgM to activate the lectin complement pathway [13] and that lectin complement pathway activation in myocardial MI/R is dependent on both MBL and IgM [14].
Positive_regulation (dependent) of Positive_regulation (activation) of IgM
2) Confidence 0.23 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.35 Pain Relevance 0.11

General Comments

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