INT102658

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 38.63
Pain Relevance 8.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
blood 14
sella 2
plasma 2
choroid plexus 2
puncture 2
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 569 100.00 Very High Very High Very High
cytokine 416 100.00 Very High Very High Very High
Multiple sclerosis 353 100.00 Very High Very High Very High
metalloproteinase 217 100.00 Very High Very High Very High
COX-2 inhibitor 35 100.00 Very High Very High Very High
antagonist 42 99.44 Very High Very High Very High
dexamethasone 37 98.36 Very High Very High Very High
corticosteroid 37 97.80 Very High Very High Very High
headache 59 97.72 Very High Very High Very High
Pain 48 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 923 100.00 Very High Very High Very High
INFLAMMATION 601 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 598 100.00 Very High Very High Very High
Demyelinating Disease 383 100.00 Very High Very High Very High
Lumbar Puncture Related Headaches 87 100.00 Very High Very High Very High
Cancer 49 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Pelvic Neoplasms 2 99.98 Very High Very High Very High
Disease 811 99.84 Very High Very High Very High
Motor Neuron Diseases 241 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aging effects on the choroid plexus and arachnoid granulations lead to a reduction in CSF production and reabsorption, ultimately resulting in the accumulation of harmful proteins.
Negative_regulation (reduction) of Gene_expression (production) of CSF in choroid plexus associated with aging
1) Confidence 0.50 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 0.52 Pain Relevance 0.07
In addition to the disproportionate CSF HIV response, CSF WBC counts were also suppressed in these subjects.
Negative_regulation (suppressed) of Gene_expression (response) of CSF associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.41 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.43 Pain Relevance 0
Preclinical studies of G-CSF and GM-CSF in CD
Negative_regulation (Preclinical) of Gene_expression (studies) of G-CSF associated with disease
3) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 1.06 Pain Relevance 0.17
Preclinical studies of G-CSF and GM-CSF in CD
Negative_regulation (Preclinical) of Gene_expression (studies) of GM-CSF associated with disease
4) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 1.06 Pain Relevance 0.17
When followed in clinic he showed a low white cell count with an absolute neutrophil count (ANC) of200 cells/microL on day 11 after cycle 2 despite being on G-CSF 300 ?
Negative_regulation (showed) of Gene_expression (being) of G-CSF in neutrophil
5) Confidence 0.37 Published 2008 Journal Cases J Section Body Doc Link PMC2615768 Disease Relevance 0.99 Pain Relevance 0.19
The most important message, repeated after other studies [11,12], is that pumping the chamber of any valve has the potential to reduce proximal CSF pressure significantly, to the extent that clinically relevant over-drainage would be possible.
Negative_regulation (reduce) of Gene_expression (pressure) of CSF in proximal
6) Confidence 0.36 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1851975 Disease Relevance 0.27 Pain Relevance 0.10
Considering that 50 mL of CSF is produced in a day in humans at a rate of approximately 0.35 mL/min, 20 mL of CSF can be removed by lumbar puncture is replenished in one hour, provided there is no persistent CSF loss through the dural puncture site or alteration in CSF production caused by lumbar puncture.
Negative_regulation (replenished) of Gene_expression (produced) of CSF in puncture associated with lumbar puncture related headaches
7) Confidence 0.36 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859586 Disease Relevance 1.18 Pain Relevance 0.46
Particularly notable in the treatment group were five subjects who achieved CSF HIV suppression despite persistent plasma viremia.
Negative_regulation (achieved) of Gene_expression (suppression) of CSF in plasma associated with acquired immune deficiency syndrome or hiv infection and viremia
8) Confidence 0.36 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.75 Pain Relevance 0
Overall effects of ART on CSF HIV infection
Negative_regulation (effects) of Gene_expression (infection) of CSF associated with acquired immune deficiency syndrome or hiv infection and infection
9) Confidence 0.36 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.33 Pain Relevance 0
Notably, however, in the context of such systemic and CSF resistance, ART can be proportionally more effective in suppressing CSF infection than in treating systemic infection.
Negative_regulation (suppressing) of Gene_expression (infection) of CSF associated with infection
10) Confidence 0.36 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.50 Pain Relevance 0
Neuroimaging revealed prominent perioptic CSF spaces in 14 patients and empty sella in three patients.
Negative_regulation (revealed) of Gene_expression (spaces) of CSF in sella associated with empty sella syndrome
11) Confidence 0.36 Published 2010 Journal Annals of Indian Academy of Neurology Section Abstract Doc Link PMC2859586 Disease Relevance 1.25 Pain Relevance 0.22
A former investigation employing rofecoxib demonstrated that PGE2 concentrations in the CSF started to decline shortly after drug administration (Buvanendran et al. 2006).
Negative_regulation (decline) of Gene_expression (concentrations) of CSF
12) Confidence 0.33 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2807935 Disease Relevance 0.16 Pain Relevance 0.28
A recent study reported a significant reduction in CSF cystatin C levels in ALS patients relative to polyneuropathy patients [16].
Negative_regulation (reduction) of Gene_expression (levels) of CSF associated with neuropathy and motor neuron diseases
13) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.99 Pain Relevance 0
The majority of cystatin C in the CSF is produced by the choroid plexus [25], but it is unclear whether the apparent reductions in CSF levels in ALS patients are an independent etiological factor contributing to motor neuron degeneration, a downstream result of disease pathogenesis, or a compensatory response to ALS pathology.
Spec (whether) Negative_regulation (reductions) of Gene_expression (levels) of CSF in motor neuron associated with disease, nerve degeneration and motor neuron diseases
14) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.78 Pain Relevance 0
As observed above, ICAM-1, IL-6, IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors.
Negative_regulation (reduced) of Gene_expression (expression) of GM-CSF
15) Confidence 0.27 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.42 Pain Relevance 0.41
peptides in blood and CSF are available for A?
Negative_regulation (available) of Gene_expression (blood) of CSF in blood
16) Confidence 0.26 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.73 Pain Relevance 0
CSF cytology, CSF white and red blood cell count, total protein, CSF to serum albumin quotient (Qalb i.e.
Negative_regulation (cytology) of Gene_expression (white) of CSF in red blood cell
17) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2998475 Disease Relevance 2.20 Pain Relevance 0.36
In this context, several studies have compared the levels of CSF and blood ?
Negative_regulation (compared) of Gene_expression (levels) of CSF in blood
18) Confidence 0.25 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 2.04 Pain Relevance 0.10
As a consequence of the discontinuation of G-CSF administration, the leukocyte count declined to 800/?
Negative_regulation (discontinuation) of Gene_expression (administration) of G-CSF in leukocyte
19) Confidence 0.25 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566578 Disease Relevance 0.79 Pain Relevance 0
IL-6 and GM-CSF expression by human ASM cells can be decreased by treatment with the glucocorticosteroid dexamethasone [11,12,13], suggesting that these cells may be an important target cell for the anti-inflammatory effects of steroids in asthma therapy [17].
Negative_regulation (decreased) of Gene_expression (expression) of GM-CSF associated with asthma, inflammation and dexamethasone
20) Confidence 0.23 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.37 Pain Relevance 0.46

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