INT10268

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Context Info
Confidence 0.39
First Reported 1982
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.08
Pain Relevance 10.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDYN, POMC) small molecule metabolic process (POMC) cell-cell signaling (POMC)
cytoplasm (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
Anatomy Link Frequency
neurons 1
pancreas 1
brain 1
posterior 1
gastric corpus 1
PDYN (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 145 100.00 Very High Very High Very High
Dynorphin 16 100.00 Very High Very High Very High
Morphine 1 100.00 Very High Very High Very High
Opioid 6 93.28 High High
Endogenous opioid 2 93.24 High High
Central nervous system 1 90.88 High High
agonist 1 78.28 Quite High
opiate 2 77.12 Quite High
midbrain 1 66.08 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 82.24 Quite High
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction of enkephalins (leu-enkephalin and met-enkephalin) and other tyrosine amino-terminal peptides with reactive oxygen species has been investigated.
leu-enkephalin Binding (interaction) of met-enkephalin associated with enkephalin
1) Confidence 0.39 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322929 Disease Relevance 0 Pain Relevance 0.44
The three classes of endogenous opioids, originating from three distinct genes, are discussed: pro-opiomelanocortin, giving rise to beta-endorphin, ACTH and various MSHs; pro-enkephalin, giving methionine enkephalin and leucine enkephalin; and prodynorphin; their anatomical distribution and the main classes of receptors with which they interact, the mu-receptor, with a high affinity for met-enkephalin and beta-endorphin (as well as morphine and dynorphin A); the delta-receptor for which the primary ligand is leu-enkephalin; and the kappa-receptor which is the main target for the dynorphins.
leu-enkephalin Binding (affinity) of beta-endorphin associated with dynorphin, endogenous opioid, enkephalin and morphine
2) Confidence 0.38 Published 1987 Journal Anaesth Intensive Care Section Abstract Doc Link 3032015 Disease Relevance 0.08 Pain Relevance 1.02
As the assays for leu-enkephalin crossreacted with those for met-enkephalin, only cyanogen bromide-treated samples were used for the determination of leu enkephalin.
leu-enkephalin Binding (crossreacted) of met-enkephalin associated with enkephalin
3) Confidence 0.30 Published 1982 Journal Life Sci. Section Abstract Doc Link 7162359 Disease Relevance 0 Pain Relevance 1.19
As the assays for leu-enkephalin crossreacted with those for met-enkephalin, only cyanogen bromide-treated samples were used for the determination of leu enkephalin.
leu-enkephalin Binding (crossreacted) of met-enkephalin associated with enkephalin
4) Confidence 0.30 Published 1982 Journal Life Sci. Section Abstract Doc Link 7162359 Disease Relevance 0 Pain Relevance 1.19
Acid extracts of human pancreas and gastric corpus and antral mucosa and muscularis were investigated for the presence of met-enkephalin and leu-enkephalin by radioimmunoassay, Sephadex chromatography and radioreceptor assay.
leu-enkephalin Binding (presence) of met-enkephalin in gastric corpus associated with enkephalin
5) Confidence 0.29 Published 1982 Journal Life Sci. Section Abstract Doc Link 7162359 Disease Relevance 0 Pain Relevance 0.92
Acid extracts of human pancreas and gastric corpus and antral mucosa and muscularis were investigated for the presence of met-enkephalin and leu-enkephalin by radioimmunoassay, Sephadex chromatography and radioreceptor assay.
leu-enkephalin Binding (presence) of met-enkephalin in pancreas associated with enkephalin
6) Confidence 0.10 Published 1982 Journal Life Sci. Section Abstract Doc Link 7162359 Disease Relevance 0 Pain Relevance 0.92
Reverse-phase HPLC analysis of enkephalin-sized immunoreactive material indicated the presence of authentic Met-enkephalin and Leu-enkephalin in the extracts of both species.
Leu-enkephalin Binding (presence) of Met-enkephalin associated with enkephalin
7) Confidence 0.09 Published 1991 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1783268 Disease Relevance 0 Pain Relevance 1.22
However, reversed-phase HPLC analysis of the pars intermedia of this species revealed the presence of Met-enkephalin, but not Leu-enkephalin.
Leu-enkephalin Binding (presence) of Met-enkephalin in pars intermedia associated with enkephalin
8) Confidence 0.05 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1478444 Disease Relevance 0 Pain Relevance 1.06
A soluble human brain aminopeptidase which hydrolyses the Tyr-Gly bond of Met-enkephalin and Leu-enkephalin was identified in the brains of the following vertebrates: mammals (Callithrix jacchus and Rattus norvegicus), bird (Gallus domesticus), reptile (Tupinambis teguixin), amphibia (Bufo paracnemis), fish (Sarotherdon niloticus) and elasmobranchy (Galeocerdo cuvieri). 2.
Leu-enkephalin Binding (bond) of Met-enkephalin in brain associated with enkephalin
9) Confidence 0.05 Published 1991 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 1685408 Disease Relevance 0 Pain Relevance 0.34
Immunocytochemical evidence for the presence of Met-enkephalin and Leu-enkephalin in distinct neurons in the brain of the elasmobranch fish Scyliorhinus canicula.
Leu-enkephalin Binding (presence) of Met-enkephalin in neurons associated with enkephalin
10) Confidence 0.03 Published 1994 Journal J. Comp. Neurol. Section Title Doc Link 7814676 Disease Relevance 0 Pain Relevance 1.05
Fractionation of acid extracts of posterior pituitaries by reverse phase HPLC followed by RIA analysis indicated the presence of immunoreactive Met-enkephalin and Leu-enkephalin.
Leu-enkephalin Binding (presence) of Met-enkephalin in posterior associated with enkephalin
11) Confidence 0.03 Published 1989 Journal Peptides Section Abstract Doc Link 2608557 Disease Relevance 0 Pain Relevance 1.01

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