INT102686

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.57
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
blood 2
neuronal 1
neurons 1
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 99.42 Very High Very High Very High
antidepressant 3 92.00 High High
fluoxetine 2 77.88 Quite High
Serotonin 1 76.68 Quite High
Desipramine 2 75.96 Quite High
Endep 3 75.32 Quite High
medulla 1 75.00 Quite High
tricyclic antidepressant 1 74.52 Quite High
parabrachial 1 59.04 Quite High
cva 18 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 10 99.90 Very High Very High Very High
Death 19 98.76 Very High Very High Very High
Injury 10 90.76 High High
Pheochromocytoma 1 82.36 Quite High
Thrombosis 42 80.92 Quite High
Disease 4 50.96 Quite High
Thrombosis Related Under Development 8 50.00 Quite Low
Thrombophilia 16 49.36 Quite Low
Hematological Disease 2 26.36 Quite Low
Hemorrhage 64 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following electrical intracochlear stimulation with a cochlear implant under urethane anesthesia, we observed changes in the phosphorylation state of the cAMP response element binding protein (CREB) and the expression of the immediate-early genes c-fos and egr-1, molecules known to act as transcription factors, in a tonotopically precise pattern in central auditory neurons.
Phosphorylation (phosphorylation) of egr-1 in neurons associated with anesthesia
1) Confidence 0.59 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12009775 Disease Relevance 0 Pain Relevance 0.17
(Briefly: elk-1 is a receptor tyrosine kinase stimulated by hypoxia; it phosphorylates the zinc-finger transcription factor early growth response-1 (egr-1), which then activates downstream genes encoding factors directly or indirectly involved in blood coagulation.)
Phosphorylation (phosphorylates) of egr-1 in blood associated with hypoxia
2) Confidence 0.17 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2925348 Disease Relevance 1.02 Pain Relevance 0
Moreover, stimulation of ERK phosphorylation and Egr-1 biosynthesis by sphingosine-1-phosphate did not induce cell death, indicating that stimulation of the ERK signaling pathway and Egr-1 biosynthesis are not required for neuronal cell death induced by antidepressants.
Phosphorylation (phosphorylation) of Egr-1 in neuronal associated with antidepressant and death
3) Confidence 0.15 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11996893 Disease Relevance 0.53 Pain Relevance 0.47
(Briefly: elk-1 is a receptor tyrosine kinase stimulated by hypoxia; it phosphorylates the zinc-finger transcription factor early growth response-1 (egr-1), which then activates downstream genes encoding factors directly or indirectly involved in blood coagulation.)
Phosphorylation (phosphorylates) of early growth response-1 in blood associated with hypoxia
4) Confidence 0.15 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2925348 Disease Relevance 1.02 Pain Relevance 0

General Comments

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