INT102690

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1B, ITGAL) cytosol (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell adhesion (ITGAL)
Anatomy Link Frequency
chondrocytes 1
IL1B (Homo sapiens)
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 100.00 Very High Very High Very High
Inflammation 4 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
Inflammatory mediators 4 92.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The promoter has two parts, the [-247/+20] fragment of the human type IIA secreted phospholipase A2 gene promoter, which is stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta), and a double peroxisome proliferator-activated receptor response element that is activated by some eicosanoids and by non-steroidal anti-inflammatory drugs (NSAIDs).
IL-1beta Positive_regulation (stimulated) of promoter associated with inflammation, cinod and cytokine
1) Confidence 0.05 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 11997019 Disease Relevance 0.46 Pain Relevance 0.49
Transfection experiments using rabbit articular chondrocytes in primary culture showed that this chimeric promoter produced a low basal activity and was induced by NSAIDs, WY-14643, IL-1beta, and 15-deoxy Delta12,14 prostaglandin J2.
IL-1beta Positive_regulation (induced) of promoter in chondrocytes associated with cinod
2) Confidence 0.05 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 11997019 Disease Relevance 0.42 Pain Relevance 0.50

General Comments

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