INT102695

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Context Info
Confidence 0.73
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
T cells 1
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 98.68 Very High Very High Very High
cytokine 1 98.16 Very High Very High Very High
Inflammatory mediators 2 93.80 High High
cINOD 3 91.32 High High
psoriasis 25 79.64 Quite High
corticosteroid 2 59.84 Quite High
methotrexate 4 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 98.68 Very High Very High Very High
Disease 2 93.36 High High
Adhesions 2 89.36 High High
Autoimmune Disease 1 87.16 High High
Psoriasis 28 79.64 Quite High
Pruritus 1 71.12 Quite High
Dermatological Disease 1 64.60 Quite High
Thrombocytopenia 19 50.00 Quite Low
Viral Meningitis 1 18.88 Low Low
Leukocytosis 7 15.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Efalizumab is a humanized monoclonal IgG1 antibody directed against CD11a, the alpha subunit of leukocyte function-associated antigen 1 on T cells.
Localization (directed) of CD11a in T cells
1) Confidence 0.73 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727906 Disease Relevance 0.81 Pain Relevance 0.13
The promoter has two parts, the [-247/+20] fragment of the human type IIA secreted phospholipase A2 gene promoter, which is stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta), and a double peroxisome proliferator-activated receptor response element that is activated by some eicosanoids and by non-steroidal anti-inflammatory drugs (NSAIDs).
Localization (secreted) of promoter associated with inflammation, cinod and cytokine
2) Confidence 0.07 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 11997019 Disease Relevance 0.45 Pain Relevance 0.48

General Comments

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