INT102719

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 3.00
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDPK1) nucleoplasm (PDPK1) cytoplasmic membrane-bounded vesicle (PDPK1)
plasma membrane (PDPK1) nucleus (PDPK1) kinase activity (PDPK1)
Anatomy Link Frequency
HT-29 3
PDPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 81.96 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 8 99.60 Very High Very High Very High
Apoptosis 12 99.20 Very High Very High Very High
Familial Adenomatous Polyposis 4 96.48 Very High Very High Very High
Polyps 4 94.56 High High
Cancer 4 88.00 High High
Death 4 84.08 Quite High
INFLAMMATION 4 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in vitro measurement reveals that celecoxib was a potential inhibitor of PDK1 activity with an IC(50) = 3.5 microm.
Negative_regulation (inhibitor) of PDK1
1) Confidence 0.58 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.70 Pain Relevance 0.05
Here, we show that celecoxib induces apoptosis in the colon cancer cell line HT-29 by inhibiting the 3-phosphoinositide-dependent kinase 1 (PDK1) activity.
Negative_regulation (inhibiting) of 3-phosphoinositide-dependent kinase 1 in HT-29 associated with colon cancer and apoptosis
2) Confidence 0.58 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.84 Pain Relevance 0.08
Here, we show that celecoxib induces apoptosis in the colon cancer cell line HT-29 by inhibiting the 3-phosphoinositide-dependent kinase 1 (PDK1) activity.
Negative_regulation (inhibiting) of PDK1 in HT-29 associated with colon cancer and apoptosis
3) Confidence 0.58 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.84 Pain Relevance 0.08
These data indicate that inhibition of PDK1 signaling is involved in the proapoptotic effect of celecoxib in HT-29 cells.
Negative_regulation (inhibition) of PDK1 in HT-29
4) Confidence 0.43 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.62 Pain Relevance 0

General Comments

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