INT10272

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1987
Last Reported 2011
Negated 0
Speculated 14
Reported most in Abstract
Documents 194
Total Number 210
Disease Relevance 121.02
Pain Relevance 103.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
brain 22
paw 11
macrophages 9
spinal cord 9
DRG 7
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 469 100.00 Very High Very High Very High
cytokine 427 100.00 Very High Very High Very High
Hyperalgesia 185 100.00 Very High Very High Very High
Pain 132 100.00 Very High Very High Very High
Hippocampus 94 100.00 Very High Very High Very High
substance P 54 100.00 Very High Very High Very High
Nerve growth factor 52 100.00 Very High Very High Very High
allodynia 33 100.00 Very High Very High Very High
analgesia 25 100.00 Very High Very High Very High
bradykinin 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 574 100.00 Very High Very High Very High
Hyperalgesia 230 100.00 Very High Very High Very High
Pain 98 100.00 Very High Very High Very High
Neuropathic Pain 95 100.00 Very High Very High Very High
Cancer 54 100.00 Very High Very High Very High
Necrosis 47 100.00 Very High Very High Very High
Adhesions 24 100.00 Very High Very High Very High
Urological Neuroanatomy 13 100.00 Very High Very High Very High
Nociception 93 99.98 Very High Very High Very High
Colitis 35 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alteration of IL-1 beta expression by exogenous factors, such as morphine, may affect the neuro-endocrine-immune axis.
Gene_expression (expression) of IL-1 beta associated with morphine
1) Confidence 0.78 Published 1996 Journal Brain Res. Section Abstract Doc Link 8814911 Disease Relevance 0 Pain Relevance 0.57
Attenuation of IL-1 beta expression in the hippocampus by chronic exposure to morphine may be one of the mechanisms underlying the neuro-endocrine-immune modulatory effects of opiate addiction.
Gene_expression (expression) of IL-1 beta in hippocampus associated with addiction, opiate, hippocampus and morphine
2) Confidence 0.78 Published 1996 Journal Brain Res. Section Abstract Doc Link 8814911 Disease Relevance 0.09 Pain Relevance 0.79
Chronic exposure to morphine attenuates expression of interleukin-1 beta in the rat hippocampus.
Gene_expression (expression) of interleukin-1 beta in hippocampus associated with hippocampus and morphine
3) Confidence 0.78 Published 1996 Journal Brain Res. Section Title Doc Link 8814911 Disease Relevance 0 Pain Relevance 0.74
The type of cells expressing IL-1 beta mRNA was likely glia because their nuclei were densely stained by Cresyl violet and were relatively small.
Gene_expression (expressing) of IL-1 beta mRNA
4) Confidence 0.78 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8731433 Disease Relevance 0 Pain Relevance 0.08
Qualitative assessment of spinal cord glial activation and IL-beta expression was performed.
Gene_expression (expression) of IL-beta in spinal cord
5) Confidence 0.78 Published 2001 Journal Spine Section Body Doc Link 11698881 Disease Relevance 0.11 Pain Relevance 0
The current study investigated the expression of IL-1 beta in the brain of rats with spared nerve injury (SNI), using immunohistochemical technique.
Spec (investigated) Gene_expression (expression) of IL-1 beta in brain associated with nervous system injury
6) Confidence 0.78 Published 2008 Journal Exp Brain Res Section Abstract Doc Link 18431565 Disease Relevance 0.77 Pain Relevance 0.23
These results suggest that interleukin-1 beta produces biphasic effects on the mechanical nociceptive threshold through the interleukin-1 receptor in the brain and that a corticotropin-releasing factor-mediated pathway is involved.
Gene_expression (produces) of interleukin-1 beta in brain associated with nociception
7) Confidence 0.77 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8741165 Disease Relevance 0.58 Pain Relevance 0.53
Interleukin-1 beta (IL-1 beta) is synthesized in the brain in response to LPS.
Gene_expression (synthesized) of IL-1 beta in brain
8) Confidence 0.77 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12507434 Disease Relevance 0.09 Pain Relevance 0.84
Interleukin-1 beta (IL-1 beta) is synthesized in the brain in response to LPS.
Gene_expression (synthesized) of Interleukin-1 beta in brain
9) Confidence 0.77 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12507434 Disease Relevance 0.09 Pain Relevance 0.84
Excessive IL-1 beta expression is observed in neurodegenerative diseases.
Gene_expression (expression) of IL-1 beta associated with neurodegenerative disease
10) Confidence 0.77 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12507434 Disease Relevance 0.10 Pain Relevance 0.89
Although rhIL-1 beta (100 pg, i.v.) produced a fall in arterial blood pressure, baroreceptor denervation did not affect the excitatory responses of the adrenal and splenic nerves to rhIL-1 beta.
Gene_expression (produced) of rhIL-1 beta in blood
11) Confidence 0.77 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1787257 Disease Relevance 0 Pain Relevance 0
Thymulin (5 ng) also resulted in significant elevation in the levels of interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) levels in the injected paw.
Gene_expression (levels) of IL-1 beta in paw associated with nerve growth factor
12) Confidence 0.76 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417804 Disease Relevance 0.73 Pain Relevance 1.02
Thymulin (5 ng) also resulted in significant elevation in the levels of interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) levels in the injected paw.
Gene_expression (levels) of interleukin-1 beta in paw associated with nerve growth factor
13) Confidence 0.76 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417804 Disease Relevance 0.72 Pain Relevance 1.02
IL-1beta expressions in the prefrontal cortex and hippocampus at different time intervals were studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).
Gene_expression (expressions) of IL-1beta in cortex associated with hippocampus
14) Confidence 0.75 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.43 Pain Relevance 0.20
Kainic acid up-regulated the expression of the inflammatory cytokines IL-1beta and TNF-alpha, the neurotrophic factor IGF-1, and the transcription factor NF-kappaB.
Gene_expression (expression) of IL-1beta associated with inflammation and cytokine
15) Confidence 0.75 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.70 Pain Relevance 0.52
The results suggest that the increased IL-1beta expressions in the prefrontal cortex and hippocampus induced by norfloxacin with biphenylacetic acid relate to seizure activities, and that these brain regions play pivotal roles in norfloxacin-induced convulsions.
Gene_expression (expressions) of IL-1beta in hippocampus associated with convulsion and hippocampus
16) Confidence 0.75 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.59 Pain Relevance 0.26
Pentoxifylline administration resulted in a dose-dependent reduction of the production of proinflammatory cytokines like TNFalpha, IL-1beta and IL-6, and enhancement of IL-10.
Gene_expression (production) of IL-1beta associated with cytokine
17) Confidence 0.75 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17140731 Disease Relevance 0.52 Pain Relevance 0.77
The inflammatory cytokines production such as TNFalpha, IL-1beta, IL-10 and nuclear factor kappa B (NF-kappaB) activity in brain was quantified using enzyme-linked immunosorbent assay (ELISA) and electrophoretic mobility shift assay (EMSA).
Gene_expression (production) of IL-1beta in brain associated with inflammation and cytokine
18) Confidence 0.75 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18248895 Disease Relevance 0.81 Pain Relevance 1.07
Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions.
Gene_expression (expressions) of IL-1beta associated with convulsion
19) Confidence 0.75 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.43 Pain Relevance 0.27
We investigated the temporal expressions of the mRNAs and the receptor mRNAs of TNFalpha, IL-1beta and IL-6 in rat dorsal root ganglia and spinal cord in a chronic constriction injury model of neuropathic pain.
Spec (investigated) Gene_expression (expressions) of IL-1beta in spinal cord associated with eae, injury, neuropathic pain and spinal cord
20) Confidence 0.75 Published 2004 Journal Neuroreport Section Abstract Doc Link 15597059 Disease Relevance 0.63 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox