INT102720

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.61
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDPK1) nucleoplasm (PDPK1) cytoplasmic membrane-bounded vesicle (PDPK1)
plasma membrane (PDPK1) nucleus (PDPK1) kinase activity (PDPK1)
PDPK1 (Homo sapiens)
PDPK1 - A280V (1)
Pain Link Frequency Relevance Heat
cINOD 2 65.84 Quite High
Disease Link Frequency Relevance Heat
Death 2 99.40 Very High Very High Very High
Apoptosis 6 94.80 High High
Colon Cancer 4 83.08 Quite High
Familial Adenomatous Polyposis 2 80.36 Quite High
Polyps 2 78.44 Quite High
Cancer 2 71.88 Quite High
INFLAMMATION 2 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, overexpression of constitutive active mutant of PDK1 (PDK1(A280V)) was as potent as the pancaspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, to impair celecoxib-induced apoptosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDK1 (A280V) associated with apoptosis
1) Confidence 0.69 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.81 Pain Relevance 0.07
In contrast, overexpression of constitutive active mutant of PDK1 (PDK1(A280V)) was as potent as the pancaspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, to impair celecoxib-induced apoptosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDK1 associated with apoptosis
2) Confidence 0.50 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.81 Pain Relevance 0.07

General Comments

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