INT102722

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Context Info
Confidence 0.82
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDPK1) nucleoplasm (PDPK1) cytoplasmic membrane-bounded vesicle (PDPK1)
plasma membrane (PDPK1) nucleus (PDPK1) kinase activity (PDPK1)
PDPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 77.16 Quite High
Morphine 3 66.48 Quite High
analgesia 2 64.60 Quite High
opiate 9 64.04 Quite High
palliative 2 61.88 Quite High
antagonist 10 48.72 Quite Low
Breakthrough pain 1 45.72 Quite Low
Pain management 1 43.64 Quite Low
Opioid 5 40.20 Quite Low
narcan 1 34.28 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 2 94.40 High High
Apoptosis 3 93.60 High High
Familial Adenomatous Polyposis 1 91.68 High High
Polyps 1 89.76 High High
Targeted Disruption 6 86.64 High High
Cancer 7 83.20 Quite High
Death 1 81.12 Quite High
Coronary Heart Disease 4 77.60 Quite High
INFLAMMATION 1 76.92 Quite High
Cv General 4 Under Development 10 75.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect was correlated with inhibition of the phosphorylation of the PDK1 downstream substrate Akt/protein kinase B (PKB) on two regulatory sites, Thr(308) and Ser(473).
Phosphorylation (phosphorylation) of PDK1
1) Confidence 0.82 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.83 Pain Relevance 0.08
Akt can also be threonine phosphorylated by PI3 kinase activation of PDK1 [41-45].
Phosphorylation (phosphorylated) of PDK1
2) Confidence 0.18 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.32
itself following PDK-1 dependent phosphorylation of Thr 566[24].
Phosphorylation (phosphorylation) of PDK-1
3) Confidence 0.03 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1142330 Disease Relevance 0.56 Pain Relevance 0

General Comments

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