INT102729

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 8.86
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (APCS) protein folding (APCS) extracellular space (APCS)
extracellular region (APCS) protein complex (APCS)
Anatomy Link Frequency
monocytes 1
muscle 1
plaques 1
NK cells 1
T-cells 1
APCS (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 24 100.00 Very High Very High Very High
Dopamine 232 99.76 Very High Very High Very High
agonist 16 90.44 High High
Etanercept 2 89.96 High High
cva 42 81.52 Quite High
ketamine 1 71.40 Quite High
cINOD 70 70.72 Quite High
ischemia 12 61.72 Quite High
aspirin 12 54.96 Quite High
Inflammation 79 50.00 Quite Low
Disease Link Frequency Relevance Heat
Stable Angina Pectoris 20 100.00 Very High Very High Very High
Hypoxia 224 99.96 Very High Very High Very High
Myocardial Infarction 109 99.66 Very High Very High Very High
Acute Coronary Syndrome 14 99.16 Very High Very High Very High
Thrombosis 8 99.14 Very High Very High Very High
Stomatitis 14 97.44 Very High Very High Very High
Immunization 32 96.36 Very High Very High Very High
Rupture 2 95.76 Very High Very High Very High
Cancer 26 95.64 Very High Very High Very High
Hypertension 20 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: The differences between acute coronary syndrome (ACS) and stable angina pectoris (SAP) in Toll-like receptor (TLR) expression levels in coronary plaques are not well known.
Gene_expression (expression) of SAP in plaques associated with stable angina pectoris, acute coronary syndrome and angina
1) Confidence 0.65 Published 2009 Journal Circ. J. Section Abstract Doc Link 19556696 Disease Relevance 0.62 Pain Relevance 0.36
TLR2 and TLR4 expression levels in the PBMCs were significantly higher in the ACS group than in the SAP group.
Gene_expression (group) of SAP
2) Confidence 0.65 Published 2009 Journal Circ. J. Section Body Doc Link 19556696 Disease Relevance 0.18 Pain Relevance 0
The TLR4 expression levels were significantly higher in the ACS group than in the SAP group.
Gene_expression (group) of SAP
3) Confidence 0.65 Published 2009 Journal Circ. J. Section Body Doc Link 19556696 Disease Relevance 0.15 Pain Relevance 0
Intracoronary thrombus was observed in 8% of AMI, but it was not found in SAP.
Neg (not) Gene_expression (found) of SAP associated with angina, myocardial infarction and thrombosis
4) Confidence 0.65 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20102942 Disease Relevance 2.20 Pain Relevance 0.61
The amplitude of SAP reduction was greater in anesthetized models, while the amplitude of HR reduction was greater in the conscious and anesthetized cynomolgus models than in the anesthetized rhesus model.
Gene_expression (reduction) of SAP
5) Confidence 0.59 Published 2008 Journal J Pharmacol Toxicol Methods Section Body Doc Link 18583160 Disease Relevance 0 Pain Relevance 0
All data were expressed as a ratio of ICP:SAP.
Gene_expression (expressed) of SAP
6) Confidence 0.58 Published 2002 Journal J. Androl. Section Abstract Doc Link 12002434 Disease Relevance 0.24 Pain Relevance 0
The dose level of 2 mg/kg SAP was chosen as this approximately doubles predicted endogenous SAP levels in the hamster.


Gene_expression (levels) of SAP
7) Confidence 0.37 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 0.92 Pain Relevance 0.04
The donor's APCs present in the graft cause the "direct" activation of the recipient's T helper cells.
Gene_expression (present) of APCs
8) Confidence 0.30 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.26 Pain Relevance 0.03
CD40 is expressed on all APCs (including B cells) and its ligand (CD40L or CD154) is on activated CD4+ T-cells and on a subset of CD8+ T-cells and NK cells.
Gene_expression (expressed) of APCs in T-cells
9) Confidence 0.28 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
Vaccines are classically injected into a muscle, where the local deposit of vaccine compound must be captured by locally present and recruited APCs.
Gene_expression (present) of APCs in muscle
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.56 Pain Relevance 0
It has been suggested that differential targeting of epidermal or dermal APCs might also produce differential immune responses [21], [23].
Gene_expression (produce) of APCs
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.55 Pain Relevance 0
The SAP/PAP ratio was lowered significantly with 32 ?
Gene_expression (ratio) of SAP
12) Confidence 0.17 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.43 Pain Relevance 0.29
The SAP/PAP ratio during 32 ?
Gene_expression (ratio) of SAP
13) Confidence 0.17 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.26 Pain Relevance 0.34
Freshly isolated or pre-activated monocytes were washed and used as APCs for autologous bulk TCR??
Gene_expression (used) of APCs in monocytes
14) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.17 Pain Relevance 0.04
Another intriguing innate-like aspect is their potential to act as professional antigen-presenting cells (APCs), which includes uptake and processing of antigens and the induction of antigen-specific ??
Gene_expression (presenting) of APCs
15) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.31 Pain Relevance 0.03
We demonstrated an increase in oxygen delivery consequent on the use of epinephrine during hypoxia; SAP was maintained and CI increased throughout the dose range (0.2-3.2 ?
Gene_expression (maintained) of SAP associated with hypoxia
16) Confidence 0.15 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.34 Pain Relevance 0.15
There was no significant effect on SAP, CI (Fig. 1) or calculated SVRI (Fig. 2) with any dose of dopamine, PAP was elevated at all doses, and a significant increase in calculated PVRI was demonstrated only at 10 ?
Neg (no) Gene_expression (effect) of SAP associated with dopamine
17) Confidence 0.15 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.48 Pain Relevance 0.24
CD40 is expressed on all APCs (including B cells) and its ligand (CD40L or CD154) is on activated CD4+ T-cells and on a subset of CD8+ T-cells and NK cells.
Gene_expression (expressed) of APCs in NK cells
18) Confidence 0.10 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
The APC and pre-SAP studies
Gene_expression (studies) of pre-SAP
19) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376081 Disease Relevance 0.80 Pain Relevance 0.09
The APC, pre-SAP and ADAPT trials were not included in this analysis.
Gene_expression (pre-SAP) of pre-SAP
20) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376081 Disease Relevance 0.40 Pain Relevance 0.29

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