INT10273

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Context Info
Confidence 0.68
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 47
Total Number 50
Disease Relevance 31.15
Pain Relevance 26.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
endothelial cells 8
hippocampus 7
paw 6
nerve 6
macrophages 5
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 129 100.00 Very High Very High Very High
Inflammatory response 53 100.00 Very High Very High Very High
Hyperalgesia 50 100.00 Very High Very High Very High
Hippocampus 41 100.00 Very High Very High Very High
substance P 19 100.00 Very High Very High Very High
Dorsal horn 9 100.00 Very High Very High Very High
glial activation 5 100.00 Very High Very High Very High
Inflammation 82 99.98 Very High Very High Very High
intrathecal 10 99.98 Very High Very High Very High
Intracerebroventricular 5 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 136 100.00 Very High Very High Very High
Hyperalgesia 72 100.00 Very High Very High Very High
Adhesions 8 100.00 Very High Very High Very High
Infection 4 100.00 Very High Very High Very High
Brain Injury 3 99.98 Very High Very High Very High
Convulsion 49 99.90 Very High Very High Very High
Shock 4 99.64 Very High Very High Very High
Inflammatory Bowel Disease 5 99.62 Very High Very High Very High
Pain 18 99.12 Very High Very High Very High
Stress 18 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thymulin (5 ng) also resulted in significant elevation in the levels of interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) levels in the injected paw.
Positive_regulation (elevation) of Gene_expression (levels) of IL-1 beta in paw associated with nerve growth factor
1) Confidence 0.68 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417804 Disease Relevance 0.73 Pain Relevance 1.03
The results suggest that the increased IL-1beta expressions in the prefrontal cortex and hippocampus induced by norfloxacin with biphenylacetic acid relate to seizure activities, and that these brain regions play pivotal roles in norfloxacin-induced convulsions.
Positive_regulation (increased) of Gene_expression (expressions) of IL-1beta in hippocampus associated with convulsion and hippocampus
2) Confidence 0.67 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.60 Pain Relevance 0.26
Irradiation significantly increased the levels of neurotensin, Il-1beta, and TNF-alpha in both layers.
Positive_regulation (increased) of Gene_expression (levels) of Il-1beta
3) Confidence 0.67 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741457 Disease Relevance 0.16 Pain Relevance 0.85
Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions.
Neg (not) Positive_regulation (increase) of Gene_expression (expressions) of IL-1beta associated with convulsion
4) Confidence 0.67 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.43 Pain Relevance 0.27
Chronically stressed rats also exhibited anxiety-like behaviors, enhanced fecal pellet excretion, and small but significant increases in the mast cell numbers and the expression of IL-1beta and IFN-gamma.
Positive_regulation (increases) of Gene_expression (expression) of IL-1beta in mast cell associated with anxiety disorder
5) Confidence 0.67 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15746211 Disease Relevance 1.58 Pain Relevance 0.25
Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1beta, TNF-alpha, and NF-kappaB, while only blueberry was able to augment the increased IGF-1 expression.
Positive_regulation (increase) of Gene_expression (expression) of IL-1beta
6) Confidence 0.67 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.54 Pain Relevance 0.44
Our results demonstrate under conditions in vivo that active colitis is associated with enhanced interleukin-1 beta release into the colonic lumen whereas such release does not occur in remission, supporting the concept that ulcerative colitis flare-ups involve increased interleukin-1 beta production.
Positive_regulation (increased) of Gene_expression (production) of interleukin-1 beta in lumen associated with colitis and inflammatory bowel disease
7) Confidence 0.53 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 8549067 Disease Relevance 0.86 Pain Relevance 0
Further, intraportal injection of IL-1 beta (100 pg) induced reflex activation of efferent activity of the splenic (sympathetic) nerve and vagal thymic nerve.
Positive_regulation (induced) of Gene_expression (injection) of IL-1 beta in nerve
8) Confidence 0.50 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8988487 Disease Relevance 0 Pain Relevance 0.11
Cutaneous hyperalgesia induced by peripheral injection of interleukin-1 beta in the rat.
Positive_regulation (induced) of Gene_expression (injection) of interleukin-1 beta associated with hyperalgesia
9) Confidence 0.50 Published 1994 Journal Brain Res. Section Title Doc Link 7820610 Disease Relevance 0.29 Pain Relevance 0.39
Intraplantar injection of interleukin-1 beta (50 pg) significantly enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram).
Positive_regulation (enhanced) of Gene_expression (injection) of interleukin-1 beta associated with qutenza
10) Confidence 0.50 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957631 Disease Relevance 0.24 Pain Relevance 0.42
Experimental brain injury induces expression of interleukin-1 beta mRNA in the rat brain.
Positive_regulation (induces) of Gene_expression (expression) of interleukin-1 beta in brain associated with brain injury
11) Confidence 0.50 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7609633 Disease Relevance 0.56 Pain Relevance 0.33
These results suggest that enhanced proenkephalin gene expression in astrocytes by IL-1 beta may be important in neuroimmune interactions and in trauma-induced CNS injury or stress.
Positive_regulation (enhanced) of Gene_expression (expression) of IL-1 beta in astrocytes associated with stress, injury and central nervous system
12) Confidence 0.49 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.49 Pain Relevance 0.34
Thymulin (5 ng) also resulted in significant elevation in the levels of interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) levels in the injected paw.
Positive_regulation (elevation) of Gene_expression (levels) of interleukin-1 beta in paw associated with nerve growth factor
13) Confidence 0.49 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9417804 Disease Relevance 0.73 Pain Relevance 1.02
IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h.
Positive_regulation (detected) of Gene_expression (expression) of IL-1beta in cortex associated with hippocampus
14) Confidence 0.49 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.48 Pain Relevance 0.29
A significant increase in vascular permeability, NOS-2 activity, TNF-alpha, IL-1beta levels and oxidative damage were noted in aspirin administered rats.
Positive_regulation (increase) of Gene_expression (levels) of IL-1beta associated with aspirin
15) Confidence 0.49 Published 2006 Journal Chem. Biol. Interact. Section Abstract Doc Link 16797507 Disease Relevance 0.46 Pain Relevance 0.25
We found that prolonged knockdown of TLR4 during the 3-day administration of TLR4 small interfering RNA (siRNA; 2 microg/rat/day, i.t.) could attenuate hyperalgesia developed by Walker 256 cells' inoculation and decrease the phosphorylation of p38 as well as the increase of IL-1beta and TNF-alpha expression.
Positive_regulation (increase) of Gene_expression (expression) of IL-1beta associated with hyperalgesia
16) Confidence 0.49 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.05 Pain Relevance 1.02
Leishmania major: interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats.
Positive_regulation (increases) of Gene_expression (levels) of interleukin-1beta associated with hyperalgesia and infection
17) Confidence 0.49 Published 2009 Journal Exp. Parasitol. Section Title Doc Link 19061890 Disease Relevance 0.79 Pain Relevance 0.56
TNF-alpha and IL-1beta levels were also significantly increased in both serum and sciatic nerve of ethanol-treated rats.
Positive_regulation (increased) of Gene_expression (levels) of IL-1beta in sciatic nerve associated with sciatic nerve
18) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19541419 Disease Relevance 0.99 Pain Relevance 0.98
Spinal cord long-term potentiation (LTP) is associated with increased dorsal horn gene expression of IL-1beta, GDNF and iNOS.
Positive_regulation (increased) of Gene_expression (expression) of IL-1beta in dorsal horn associated with dorsal horn, long-term potentiation and spinal cord
19) Confidence 0.49 Published 2010 Journal Eur J Pain Section Title Doc Link 19596210 Disease Relevance 0.22 Pain Relevance 0.79
For the first time we show that spinal cord LTP is associated with an increased dorsal horn expression of the genes for IL-1beta, GDNF and iNOS.
Positive_regulation (increased) of Gene_expression (expression) of IL-1beta in spinal cord associated with dorsal horn, long-term potentiation and spinal cord
20) Confidence 0.49 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19596210 Disease Relevance 0.22 Pain Relevance 0.78

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