INT102731

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 2
Speculated 6
Reported most in Abstract
Documents 29
Total Number 36
Disease Relevance 5.36
Pain Relevance 11.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
Claw 5
colon 2
blood 1
CAR 1
epithelial cells 1
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 81 100.00 Very High Very High Very High
Opioid 26 99.84 Very High Very High Very High
depression 7 99.70 Very High Very High Very High
narcan 12 99.00 Very High Very High Very High
Transcranial magnetic stimulation 126 98.36 Very High Very High Very High
Oxycodone 3 98.12 Very High Very High Very High
tolerance 2 98.12 Very High Very High Very High
Morphine 12 97.96 Very High Very High Very High
Bioavailability 4 97.60 Very High Very High Very High
cINOD 20 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pruritus 1 99.88 Very High Very High Very High
Cancer 185 99.80 Very High Very High Very High
Respiratory Failure 1 99.70 Very High Very High Very High
Toxicity 28 98.88 Very High Very High Very High
Carcinoma 6 97.60 Very High Very High Very High
Leukemia 10 97.32 Very High Very High Very High
INFLAMMATION 46 96.00 Very High Very High Very High
Pain 303 95.52 Very High Very High Very High
Skin Cancer 8 95.00 High High
Colon Cancer 29 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of both P-gp activity and P-gp expression by Devil's Claw raise the possibility of herb-drug interactions, to be further explored in depth.


Regulation (Modulation) of P-gp in Claw
1) Confidence 0.62 Published 2009 Journal Phytomedicine Section Body Doc Link 19577448 Disease Relevance 0.10 Pain Relevance 0
The goal of this article is to highlight important findings in the field of methylation and explain how they impinge on MDR1 gene regulation.
Regulation (regulation) of MDR1 gene
2) Confidence 0.61 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 14567978 Disease Relevance 0.34 Pain Relevance 0
The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells).
Spec (investigate) Regulation (modulation) of P-glycoprotein in colon associated with qutenza and colon cancer
3) Confidence 0.60 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.09 Pain Relevance 0.29
The aim of this paper is to review the regulation of P-glycoprotein (P-gp) by dietary components and to correlate the changes in cellular P-gp function and expression with drug bioavailability.
Regulation (regulation) of P-glycoprotein associated with bioavailability
4) Confidence 0.60 Published 2009 Journal Expert Opin Drug Metab Toxicol Section Abstract Doc Link 19545213 Disease Relevance 0 Pain Relevance 0.14
The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells).
Spec (investigate) Regulation (modulation) of MDR-1 in colon associated with qutenza and colon cancer
5) Confidence 0.51 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.09 Pain Relevance 0.29
Additionally, polymorphisms affecting the activity of the
               multidrug resistance protein ABCB1 (MDR1), which is a major
               determinant of morphine bioavailability, can alter the efficacy of morphine pain
               relief [61], presumably by affecting the rate at which morphine
               and its metabolites are removed from the cell.
Regulation (affecting) of MDR1 associated with pain, bioavailability and morphine
6) Confidence 0.46 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.34 Pain Relevance 1.70
Therefore, the effect of MDR1 siRNA loaded nanoparticles was examined for the uptake and efflux of a P-gp substrate, calcein AM, in KHOSR2.
Spec (examined) Regulation (effect) of MDR1 siRNA
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.05 Pain Relevance 0
However, its efficacy is usually limited by the development of multidrug resistance (MDR), which has been linked to the up-regulation of P-glycoprotein (P-gp) in cancer cells.
Regulation (regulation) of P-gp associated with cancer
8) Confidence 0.44 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19264847 Disease Relevance 0.53 Pain Relevance 0.14
Thus, the present study provides further evidence that repeated exposure to dietary ingredients can cause drug-food interactions by affecting the function and mRNA expression of intestinal transporters such as P-glycoprotein.
Regulation (affecting) of P-glycoprotein
9) Confidence 0.44 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0 Pain Relevance 0.23
We next examined the effects of Cap on the activity of P-glycoprotein (P-gp) found on transcellular transporters.
Spec (examined) Regulation (effects) of P-glycoprotein associated with qutenza
10) Confidence 0.44 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17917278 Disease Relevance 0.15 Pain Relevance 1.09
We next examined the effects of Cap on the activity of P-glycoprotein (P-gp) found on transcellular transporters.
Spec (examined) Regulation (effects) of P-gp associated with qutenza
11) Confidence 0.44 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17917278 Disease Relevance 0.15 Pain Relevance 1.10
In conclusion, our results suggest that P-glycoprotein-mediated efflux is significantly affected by dietary ingredients.
Regulation (affected) of P-glycoprotein
12) Confidence 0.44 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0 Pain Relevance 0.38
Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.
Regulation (Effects) of P-glycoprotein in epithelial cells associated with qutenza
13) Confidence 0.44 Published 2010 Journal Biol. Pharm. Bull. Section Title Doc Link 20118549 Disease Relevance 0.09 Pain Relevance 0.42
The theoretical effect of P-glycoprotein mediated drug efflux on the cerebral distribution volumes of drugs was examined, with particular emphasis on anaesthetic-related drugs (often characterized by moderate to high permeability across the blood brain barrier due to their lipophilicity and intermediate molecular weight).
Spec (examined) Regulation (effect) of P-glycoprotein in blood
14) Confidence 0.44 Published 2002 Journal Anaesth Intensive Care Section Abstract Doc Link 12002926 Disease Relevance 0 Pain Relevance 0
Additionally, polymorphisms affecting the activity of the
               multidrug resistance protein ABCB1 (MDR1), which is a major
               determinant of morphine bioavailability, can alter the efficacy of morphine pain
               relief [61], presumably by affecting the rate at which morphine
               and its metabolites are removed from the cell.
Regulation (affecting) of ABCB1 associated with pain, bioavailability and morphine
15) Confidence 0.40 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.28 Pain Relevance 1.65
The siRNA sequence targeting ABCB1 (Genbank accession no.
Regulation (targeting) of ABCB1
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.07 Pain Relevance 0
Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein.
Regulation (Effects) of P-glycoprotein in Claw
17) Confidence 0.26 Published 2009 Journal Phytomedicine Section Title Doc Link 19577448 Disease Relevance 0.09 Pain Relevance 0.14
Alteration in P-gp or cytochrome production or function in the elderly could possibly lead to altered responses to drugs (Bressler and Bahl 2003; Kinirons and O’Mahony 2004).
Regulation (Alteration) of P-gp
18) Confidence 0.26 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 0.66 Pain Relevance 0.03
The effects of dietary phytochemicals on P-glycoprotein function were investigated using human multidrug-resistant carcinoma KB-C2 cells and the fluorescent P-glycoprotein substrates daunorubicin and rhodamine 123.
Regulation (effects) of P-glycoprotein associated with carcinoma
19) Confidence 0.26 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15649425 Disease Relevance 0.10 Pain Relevance 0.14
Effects of dietary chemopreventive phytochemicals on P-glycoprotein function.
Regulation (Effects) of P-glycoprotein associated with qutenza
20) Confidence 0.26 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15649425 Disease Relevance 0.09 Pain Relevance 0.32

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