INT102739

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Bhlhe22)
Anatomy Link Frequency
platelet 1
Bhlhe22 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 3 99.60 Very High Very High Very High
agonist 2 95.92 Very High Very High Very High
anesthesia 5 95.44 Very High Very High Very High
antagonist 4 83.60 Quite High
withdrawal 1 77.92 Quite High
Angina 2 74.36 Quite High
aspirin 2 35.60 Quite Low
Disease Link Frequency Relevance Heat
Vasculitis 2 88.52 High High
Stroke 4 75.20 Quite High
Sleep Disorders 3 75.00 Quite High
Cv General 3 Under Development 2 74.36 Quite High
Myocardial Infarction 2 73.68 Quite High
Injury 2 70.96 Quite High
Unconsciousness 1 67.92 Quite High
Apoptosis 2 25.00 Low Low
Adhesions 2 25.00 Low Low
Acute Coronary Syndrome 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ensuing inside-out signaling increases several-fold the affinity and avidity of alphaIIb/beta3 for its ligands.
beta3 Binding (affinity) of
1) Confidence 0.36 Published 2002 Journal Crit. Care Med. Section Abstract Doc Link 12004256 Disease Relevance 0.38 Pain Relevance 0.20
High affinity ligand binding to alphaIIb/beta3 triggers outside-in signaling, causing microskeletal contraction and platelet retraction.
beta3 Binding (binding) of in platelet
2) Confidence 0.36 Published 2002 Journal Crit. Care Med. Section Abstract Doc Link 12004256 Disease Relevance 0.37 Pain Relevance 0.20
The intravenous general anesthetic etomidate acts by potentiating GABA(A) receptors, with selectivity for beta2 and beta3 subunit-containing receptors determined by a single asparagine residue.
beta3 Binding (selectivity) of associated with gaba
3) Confidence 0.36 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 13679430 Disease Relevance 0.20 Pain Relevance 0.43

General Comments

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