INT10274

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2010
Negated 1
Speculated 11
Reported most in Abstract
Documents 123
Total Number 140
Disease Relevance 79.76
Pain Relevance 73.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
spinal cord 9
brain 7
spinal 6
nerve 6
hypothalamus 5
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 264 100.00 Very High Very High Very High
cytokine 257 100.00 Very High Very High Very High
Spinal cord 76 100.00 Very High Very High Very High
Enkephalin 30 100.00 Very High Very High Very High
Opioid 19 100.00 Very High Very High Very High
Central nervous system 18 100.00 Very High Very High Very High
COX2 10 100.00 Very High Very High Very High
Hyperalgesia 98 99.98 Very High Very High Very High
Morphine 47 99.98 Very High Very High Very High
narcan 23 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 331 100.00 Very High Very High Very High
Cancer 28 100.00 Very High Very High Very High
Necrosis 24 100.00 Very High Very High Very High
Adhesions 18 100.00 Very High Very High Very High
Fever 18 100.00 Very High Very High Very High
Appetite Loss 16 100.00 Very High Very High Very High
Peptic Ulcer 13 100.00 Very High Very High Very High
Hyperalgesia 127 99.98 Very High Very High Very High
Inflammatory Bowel Disease 6 99.98 Very High Very High Very High
Pain 90 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 beta mRNA was markedly induced in the hypothalamus after the injection of formalin into both hind paws.
Positive_regulation (induced) of IL-1 beta mRNA in hypothalamus
1) Confidence 0.70 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8731433 Disease Relevance 0 Pain Relevance 0.07
The induction of interleukin-1 beta (IL-1 beta) mRNA in the rat brain following subcutaneous injection of formalin into the hind paws was investigated by in situ hydridization.
Spec (investigated) Positive_regulation (induction) of interleukin-1 beta in brain
2) Confidence 0.70 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8731433 Disease Relevance 0 Pain Relevance 0.05
Induction of interleukin-1 beta mRNA in the hypothalamus following subcutaneous injections of formalin into the rat hind paws.
Positive_regulation (Induction) of interleukin-1 beta in hypothalamus
3) Confidence 0.70 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 8731433 Disease Relevance 0 Pain Relevance 0.07
The present results suggest that IL-1 beta mRNA is induced in the glial cells of the hypothalamus by persistent pain which is caused by formalin injection.
Positive_regulation (induced) of IL-1 beta mRNA in hypothalamus associated with pain and lasting pain
4) Confidence 0.70 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8731433 Disease Relevance 0.10 Pain Relevance 0.10
The results showed that immunoreactive-like IL-1 beta protein was significantly elevated in the Red nucleus (RN) 2 weeks after SNI.
Spec (like) Positive_regulation (elevated) of IL-1 beta protein in Red nucleus associated with nervous system injury
5) Confidence 0.70 Published 2008 Journal Exp Brain Res Section Abstract Doc Link 18431565 Disease Relevance 0.89 Pain Relevance 0.35
This upregulation of binding sites for the opioid-releasing agents corticotropin-releasing hormone and interleukin-1 beta likely represents part of the body's local response to combat inflammatory pain.
Positive_regulation (upregulation) of interleukin-1 beta in body associated with ipn and opioid
6) Confidence 0.69 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8891603 Disease Relevance 0.24 Pain Relevance 0.93
Between attacks, IL-1 beta was also significantly increased compared to controls.
Positive_regulation (increased) of IL-1 beta
7) Confidence 0.68 Published 1993 Journal Cephalalgia Section Abstract Doc Link 7694804 Disease Relevance 0.44 Pain Relevance 0.53
There was an increase in IL-1 beta in all CH patients compared to controls.
Positive_regulation (increase) of IL-1 beta associated with cluster headache
8) Confidence 0.68 Published 1993 Journal Cephalalgia Section Abstract Doc Link 7694804 Disease Relevance 0.46 Pain Relevance 0.53
IL-1 beta was further increased during the ictal phase of CH compared to patients between attacks and normal individuals.
Positive_regulation (increased) of IL-1 beta associated with cluster headache
9) Confidence 0.68 Published 1993 Journal Cephalalgia Section Abstract Doc Link 7694804 Disease Relevance 0.46 Pain Relevance 0.54
Serum interleukin-1 beta is increased in cluster headache.
Positive_regulation (increased) of interleukin-1 beta associated with cluster headache
10) Confidence 0.68 Published 1993 Journal Cephalalgia Section Title Doc Link 7694804 Disease Relevance 0.47 Pain Relevance 0.55
Because levels of the cytokine interleukin-1 beta (IL-1 beta) increase following CNS lesions, we examined the possible influence of IL-1 beta on the expression of opioid genes in astrocytes cultured from rat cortex.
Spec (examined) Positive_regulation (increase) of IL-1 beta in cortex associated with central nervous system, opioid and cytokine
11) Confidence 0.68 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.28 Pain Relevance 0.48
Because levels of the cytokine interleukin-1 beta (IL-1 beta) increase following CNS lesions, we examined the possible influence of IL-1 beta on the expression of opioid genes in astrocytes cultured from rat cortex.
Spec (examined) Positive_regulation (increase) of cytokine interleukin-1 beta in cortex associated with central nervous system, opioid and cytokine
12) Confidence 0.68 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.28 Pain Relevance 0.49
Real-time polymerase chain reaction (PCR) and immunohistochemisty showed that IL-1beta mRNA and protein level in the spinal cord was transiently upregulated after surgical incision.
Positive_regulation (upregulated) of IL-1beta in spinal cord associated with spinal cord
13) Confidence 0.67 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733810 Disease Relevance 0.09 Pain Relevance 0.41
Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions.
Neg (not) Positive_regulation (increase) of IL-1beta associated with convulsion
14) Confidence 0.67 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16824509 Disease Relevance 0.43 Pain Relevance 0.27
Increases in the gastric content of TNF-alpha and IL-1beta after aspirin administration were inhibited by pretreatment with rolipram.
Positive_regulation (Increases) of IL-1beta associated with aspirin
15) Confidence 0.67 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 15986861 Disease Relevance 0.36 Pain Relevance 0.48
To identify the part of the brain that is affected by hyperalgesia-induced IL-1beta and the possible site of alpha-MSH inhibition, we have examined Fos expression in the rat brain in response to ICV microinjection of alpha-MSH and/or IL-1beta.
Spec (possible) Positive_regulation (induced) of IL-1beta in brain associated with hyperalgesia and intracerebroventricular
16) Confidence 0.67 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16015027 Disease Relevance 0.43 Pain Relevance 0.52
The results showed that: (1) inoculation of prostate cancer cells, but not the vehicle Hank's solution, induced progressive bone destruction at the proximal epiphysis of the tibia from day 7-20 post inoculation; (2) the inoculation also induced progressive thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia, and spontaneous flinches; (3) astrocytes and microglia were significantly activated in the spinal cord ipsilateral to the cancer leg, characterized by enhanced immunostaining of both glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglial marker); (4) IL-1beta was up-regulated in the ipsilateral spinal cord, evidenced by an increase of IL-1beta immunostained astrocytes.
Positive_regulation (up-regulated) of IL-1beta in proximal associated with hyperalgesia, allodynia, cancer, thermal hyperalgesia, reprotox - general 1 and spinal cord
17) Confidence 0.67 Published 2005 Journal Pain Section Abstract Doc Link 16154703 Disease Relevance 1.53 Pain Relevance 1.31
The results showed that: (1) inoculation of prostate cancer cells, but not the vehicle Hank's solution, induced progressive bone destruction at the proximal epiphysis of the tibia from day 7-20 post inoculation; (2) the inoculation also induced progressive thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia, and spontaneous flinches; (3) astrocytes and microglia were significantly activated in the spinal cord ipsilateral to the cancer leg, characterized by enhanced immunostaining of both glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglial marker); (4) IL-1beta was up-regulated in the ipsilateral spinal cord, evidenced by an increase of IL-1beta immunostained astrocytes.
Positive_regulation (increase) of IL-1beta in proximal associated with hyperalgesia, allodynia, cancer, thermal hyperalgesia, reprotox - general 1 and spinal cord
18) Confidence 0.67 Published 2005 Journal Pain Section Abstract Doc Link 16154703 Disease Relevance 1.51 Pain Relevance 1.31
IL-1beta was elevated 6 h after carrageenan injection in the hind paw tissue but only 24 h in the muscle tissue (P < .001).
Positive_regulation (elevated) of IL-1beta in muscle tissue
19) Confidence 0.67 Published 2007 Journal J Pain Section Abstract Doc Link 16949880 Disease Relevance 0.95 Pain Relevance 0.76
Spinal glial activation and upregulation of Interleukin-1beta appear to parallel the development and maintenance of zymosan and formalin-induced mechanical allodynia.
Positive_regulation (upregulation) of Interleukin-1beta in Spinal associated with allodynia and glial activation
20) Confidence 0.67 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350552 Disease Relevance 0.81 Pain Relevance 1.09

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