INT102744

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.97
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hmbs) cytoplasm (Hmbs)
Hmbs (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 2 90.84 High High
palliative 2 86.40 High High
cytokine 3 14.80 Low Low
Inflammation 12 12.40 Low Low
fibrosis 1 7.24 Low Low
Spinal cord 8 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Porphyria 10 99.08 Very High Very High Very High
Disease 38 96.12 Very High Very High Very High
Creutzfeldt Jakob Disease 4 95.52 Very High Very High Very High
Muscular Atrophy 4 95.04 Very High Very High Very High
Frailty 19 94.64 High High
Abdominal Pain 2 90.84 High High
Targeted Disruption 28 89.60 High High
Chronic Renal Failure 28 85.32 High High
Sepsis 5 82.76 Quite High
Starvation 1 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-viral mediated gene transfer of porphobilinogen deaminase into mammalian cells.
Positive_regulation (mediated) of Gene_expression (transfer) of porphobilinogen deaminase
1) Confidence 0.70 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Title Doc Link 12004925 Disease Relevance 0.59 Pain Relevance 0.18
mice may be indicative of a complex relationship between overexpression of mutant polyglutamine proteins and UPS function [40].
Positive_regulation (overexpression) of Gene_expression (overexpression) of UPS
2) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.39 Pain Relevance 0
Non-viral mediated gene transfer of porphobilinogen deaminase into mammalian cells.
Positive_regulation (transfer) of Gene_expression (transfer) of porphobilinogen deaminase
3) Confidence 0.47 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Title Doc Link 12004925 Disease Relevance 0.59 Pain Relevance 0.18
UPS impairment has also been observed in cell culture and animal models overexpressing mutant huntingtin protein [16]–[19], , and consistent with data proposing a protective effect of aggregation due to sequestration of toxic species, treatment with a compound that increases inclusion formation prevents huntingtin-mediated proteasome inhibition [19].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of UPS
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.45 Pain Relevance 0
Changes in atrogenes include decreased expression of various growth-related genes and increased expression of components of the UPS.
Positive_regulation (increased) of Gene_expression (expression) of UPS
5) Confidence 0.12 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.95 Pain Relevance 0

General Comments

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