INT102746

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.35
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hmbs) cytoplasm (Hmbs)
Anatomy Link Frequency
neuronal 1
muscle 1
brain 1
Hmbs (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 6 95.12 Very High Very High Very High
palliative 3 86.24 High High
peripheral neuropathy 4 81.04 Quite High
Glutamate 2 69.92 Quite High
Inflammation 26 67.12 Quite High
cytokine 19 66.88 Quite High
aspirin 1 66.16 Quite High
cINOD 3 63.60 Quite High
Dopamine 11 54.00 Quite High
fibrosis 1 43.36 Quite Low
Disease Link Frequency Relevance Heat
Frailty 39 99.92 Very High Very High Very High
Brain Injury 29 99.68 Very High Very High Very High
Disease 246 99.52 Very High Very High Very High
Targeted Disruption 25 99.42 Very High Very High Very High
Porphyria 86 98.68 Very High Very High Very High
Apoptosis 15 98.32 Very High Very High Very High
Diabetes Mellitus 68 98.08 Very High Very High Very High
Cancer 51 96.72 Very High Very High Very High
Parkinson's Disease 50 96.68 Very High Very High Very High
Adhesions 3 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute intermittent porphyria (AIP) is an inborn error of heme synthesis in which the third enzyme, porphobilinogen deaminase (PBGD), is deficient.
Negative_regulation (deficient) of porphobilinogen deaminase associated with porphyria
1) Confidence 0.59 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 12004925 Disease Relevance 0.53 Pain Relevance 0.18
Acute intermittent porphyria (AIP) is an inborn error of heme synthesis in which the third enzyme, porphobilinogen deaminase (PBGD), is deficient.
Negative_regulation (deficient) of PBGD associated with porphyria
2) Confidence 0.43 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 12004925 Disease Relevance 0.53 Pain Relevance 0.18
We then demonstrated that this reporter system is sensitive to UPS inhibition in vivo.


Negative_regulation (inhibition) of UPS
3) Confidence 0.30 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2690827 Disease Relevance 0.33 Pain Relevance 0
In this way, mitochondrial dysfunction and UPS impairment seem to be strictly involved and related in formation of alpha-synuclein aggregates, since alpha-synuclein transgenic mice show mitochondrion and UPS loss of function, as shown separately in the studies referred above.


Negative_regulation (loss) of UPS associated with targeted disruption and parkinson's disease
4) Confidence 0.12 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 1.20 Pain Relevance 0.10
Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice

Background

Negative_regulation (impaired) of UPS in brain associated with brain injury
5) Confidence 0.08 Published 2008 Journal BMC Infect Dis Section Title Doc Link PMC2442079 Disease Relevance 1.08 Pain Relevance 0
To ascertain if PD prevents muscle wasting by downregulating the UPS, protein levels of atrogin-1/MAFbx, a muscle-specific ubiquitin ligase overexpressed in pathological states associated with muscle atrophy [4], [7], were evaluated.
Negative_regulation (downregulating) of UPS in muscle associated with frailty and muscular atrophy
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.55 Pain Relevance 0.03
The proposed mechanism of action involves the ability of bortezomib to prevent the UPS-induced destruction of I?
Negative_regulation (prevent) of UPS
7) Confidence 0.07 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.36 Pain Relevance 0
utilizing mice deficient in porphobilinogen deaminase, an
Negative_regulation (deficient) of porphobilinogen deaminase
8) Confidence 0.07 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 0.60 Pain Relevance 0.12
In vitro, synaptophysin levels were also evaluated using angiotensin IIĀ–stimulated PC12D neuronal cells cultured with or without the inhibition of ERK signaling or the ubiquitin-proteasome system (UPS).
Negative_regulation (inhibition) of UPS in neuronal
9) Confidence 0.06 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494692 Disease Relevance 0.55 Pain Relevance 0
UPS inhibition has been found to be a pre-requisite for apoptosis and is already clinically exploited with the proteasome inhibitor bortezomib in multiple myeloma.
Negative_regulation (inhibition) of UPS associated with multiple myeloma and apoptosis
10) Confidence 0.03 Published 2007 Journal J. Cell. Mol. Med. Section Abstract Doc Link 17488476 Disease Relevance 1.22 Pain Relevance 0.16
porphobilinogen deaminase, heme deficiency alone may be
Negative_regulation (deficiency) of porphobilinogen deaminase
11) Confidence 0.03 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 1.40 Pain Relevance 0

General Comments

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