INT102747

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 10.53
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hmbs) cytoplasm (Hmbs)
Anatomy Link Frequency
liver 3
neurons 2
brain 2
body 1
Hmbs (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 15 96.16 Very High Very High Very High
abdominal pain 4 90.84 High High
palliative 5 89.80 High High
anesthesia 5 81.60 Quite High
Glutamate receptor 1 64.68 Quite High
ischemia 8 58.24 Quite High
Central nervous system 25 56.84 Quite High
Dopamine 11 49.44 Quite Low
midbrain 20 39.88 Quite Low
Hippocampus 20 37.24 Quite Low
Disease Link Frequency Relevance Heat
Porphyria 29 100.00 Very High Very High Very High
Parkinson's Disease 51 99.90 Very High Very High Very High
Targeted Disruption 102 99.84 Very High Very High Very High
Disease 222 99.80 Very High Very High Very High
Toxocariasis 90 99.36 Very High Very High Very High
Nervous System Heredodegenerative Disorders 2 99.24 Very High Very High Very High
Infection 44 98.52 Very High Very High Very High
Neurodegenerative Disease 58 97.40 Very High Very High Very High
Hepatic Porphyrias 4 97.12 Very High Very High Very High
Creutzfeldt Jakob Disease 12 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-viral mediated gene transfer of porphobilinogen deaminase into mammalian cells.
Gene_expression (transfer) of porphobilinogen deaminase
1) Confidence 0.78 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Title Doc Link 12004925 Disease Relevance 0.59 Pain Relevance 0.18
The study documents a successful gene transfer and a high degree of PBGD expression in different cell-lines, indicating a potential for future gene therapy in AIP.
Gene_expression (expression) of PBGD associated with porphyria
2) Confidence 0.78 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 12004925 Disease Relevance 0.37 Pain Relevance 0.11
Here we explore the efficiency of a non-viral gene delivery to obtain PBGD expression in the liver of AIP transgenic mice.
Gene_expression (expression) of PBGD in liver associated with targeted disruption and porphyria
3) Confidence 0.68 Published 2004 Journal Mol. Genet. Metab. Section Abstract Doc Link 15110317 Disease Relevance 0.85 Pain Relevance 0.18
This UPS reporter contains a degron sequence attached to the C-terminus of green fluorescent protein, and is predominantly expressed in neurons throughout the brain of our transgenic model.
Gene_expression (expressed) of UPS in brain associated with targeted disruption
4) Confidence 0.62 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2690827 Disease Relevance 0.33 Pain Relevance 0
mice may be indicative of a complex relationship between overexpression of mutant polyglutamine proteins and UPS function [40].
Gene_expression (overexpression) of UPS
5) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.39 Pain Relevance 0
Administration of Isoflurane (a single dose of 2 ml/kg, i.p) to wild-type (+/+), heterozygous (+/Fechm1Pas) and homozygous (Fechm1Pas/Fechm1Pas) mice, was evaluated by measuring the activity of delta-aminolevulinic acid synthetase (ALA-S) and Porphobilinogen-deaminase (PBG-D) in different tissues, as well as Heme oxygenase (HO), cytochrome P-450, CYP2E1 and glutathione levels in liver.
Gene_expression (synthetase) of PBG-D in liver associated with porphyria and isoflurane
6) Confidence 0.55 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268000 Disease Relevance 0.77 Pain Relevance 0.24
No alterations were found in either PBG-D or HO activities.
Gene_expression (activities) of PBG-D associated with porphyria
7) Confidence 0.55 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268000 Disease Relevance 0.76 Pain Relevance 0.26
Administration of Isoflurane (a single dose of 2 ml/kg, i.p) to wild-type (+/+), heterozygous (+/Fechm1Pas) and homozygous (Fechm1Pas/Fechm1Pas) mice, was evaluated by measuring the activity of delta-aminolevulinic acid synthetase (ALA-S) and Porphobilinogen-deaminase (PBG-D) in different tissues, as well as Heme oxygenase (HO), cytochrome P-450, CYP2E1 and glutathione levels in liver.
Gene_expression (synthetase) of Porphobilinogen-deaminase in liver associated with porphyria and isoflurane
8) Confidence 0.55 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268000 Disease Relevance 0.77 Pain Relevance 0.24
Additionally, the recent demonstration that specific inhibition of the 26S proteasome leads to a neurodegenerative phenotype [31], as well as the finding that neurons and glia display different basal levels of UPS activity [36], in vivo models expressing UPS reporters are becoming increasingly more valuable.
Gene_expression (expressing) of UPS in neurons associated with neurodegenerative disease
9) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.33 Pain Relevance 0
Thus, more efficient non-viral vectors are needed to express sufficient PBGD activity over the endogenous hepatic level (approximately 30% of normal) in this murine system.
Gene_expression (express) of PBGD
10) Confidence 0.52 Published 2004 Journal Mol. Genet. Metab. Section Abstract Doc Link 15110317 Disease Relevance 0.35 Pain Relevance 0.05
In regard to the link between UPS function and PD, multiple publications have consistently reported greater proteasomal impairment in the presence of aggregated ?
Gene_expression (function) of UPS associated with disease
11) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.33 Pain Relevance 0
UPS impairment has also been observed in cell culture and animal models overexpressing mutant huntingtin protein [16]–[19], , and consistent with data proposing a protective effect of aggregation due to sequestration of toxic species, treatment with a compound that increases inclusion formation prevents huntingtin-mediated proteasome inhibition [19].
Gene_expression (overexpressing) of UPS
12) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.45 Pain Relevance 0
In contrast to other transgenic mouse models expressing UPS reporters throughout the body [32], [33], GFP?
Gene_expression (expressing) of UPS in body associated with targeted disruption
13) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.52 Pain Relevance 0
In this review we focus those mechanisms we believe to have a central importance in the disease pathogenesis, especially mitochondrial dysfunction and UPS alteration and the correlation between both.
Gene_expression (alteration) of UPS associated with parkinson's disease and disease
14) Confidence 0.19 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.60 Pain Relevance 0.03
Changes in atrogenes include decreased expression of various growth-related genes and increased expression of components of the UPS.
Gene_expression (expression) of UPS
15) Confidence 0.14 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.95 Pain Relevance 0
The presence of elevated ubiquitin conjugates associated with intracellular deposits of aggregated protein in diseased neurons in nearly all sporadic and hereditary neurodegenerative diseases has long suggested a linkage between UPS dysfunction and pathogenesis, e.g., TBI [9] and AD [16].
Gene_expression (dysfunction) of UPS in neurons associated with nervous system heredodegenerative disorders and disease
16) Confidence 0.13 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.88 Pain Relevance 0.06
BIAB expressions and UPS function in the brains of mice inoculated with a single dose of 250 T. canis embryonated eggs was investigated from 3 days (dpi) to 8 weeks post-infection (wpi) by Western blotting and RT-PCR.


Gene_expression (expressions) of UPS in brains associated with infection
17) Confidence 0.11 Published 2008 Journal BMC Infect Dis Section Abstract Doc Link PMC2442079 Disease Relevance 1.29 Pain Relevance 0

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