INT102749

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 26.07
Pain Relevance 6.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
macrophages 2
poly 2
brain 2
cleavage 2
apoptotic cell 2
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 46 100.00 Very High Very High Very High
Paracetamol 15 99.98 Very High Very High Very High
dexamethasone 64 99.84 Very High Very High Very High
Abeta 10 98.82 Very High Very High Very High
anesthesia 6 97.96 Very High Very High Very High
fluoxetine 7 97.40 Very High Very High Very High
qutenza 18 95.86 Very High Very High Very High
nMDA receptor 16 93.60 High High
antagonist 18 87.80 High High
Inflammation 115 87.44 High High
Disease Link Frequency Relevance Heat
Apoptosis 1225 100.00 Very High Very High Very High
Death 192 100.00 Very High Very High Very High
Prostate Cancer 22 100.00 Very High Very High Very High
Skin Cancer 29 99.84 Very High Very High Very High
Stress 46 99.46 Very High Very High Very High
Leukemia 73 99.20 Very High Very High Very High
Ovarian Cancer 4 98.44 Very High Very High Very High
Injury 14 98.20 Very High Very High Very High
Alzheimer's Dementia 12 98.20 Very High Very High Very High
Delirium 6 97.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen triggered the release of cytochrome c from mitochondria into the cytosol, activation of caspase-3, 8, and 9, cleavage of poly(ADP-ribose) polymerase, and degradation of lamin B1 and DNA.
Positive_regulation (triggered) of Positive_regulation (activation) of caspase-3 in poly associated with paracetamol
1) Confidence 0.67 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12005112 Disease Relevance 0.67 Pain Relevance 0.93
Growth inhibition by sulindac sulfide was associated with a significant increase in percent G cells and activation of caspase-3.
Positive_regulation (increase) of Positive_regulation (activation) of caspase-3 in G cells
2) Confidence 0.67 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172818 Disease Relevance 0.38 Pain Relevance 0.08
Capsaicin-induced apoptosis was associated with the elevation of intracellular reactive oxygen species and Ca2+ production, decreased the levels of mitochondrial membrane potential, promoted cytochrome c release and increased the activation of caspase-3.
Positive_regulation (increased) of Positive_regulation (activation) of caspase-3 associated with qutenza and apoptosis
3) Confidence 0.60 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 16827131 Disease Relevance 0.67 Pain Relevance 0.76
To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP).
Positive_regulation (attenuate) of Positive_regulation (activation) of caspase-3 associated with anesthesia, dementia, alzheimer's dementia, delirium, isoflurane and abeta
4) Confidence 0.39 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 17234824 Disease Relevance 0.86 Pain Relevance 0.37
To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP).
Positive_regulation (isoflurane-induced) of Positive_regulation (activation) of caspase-3 associated with anesthesia, dementia, alzheimer's dementia, delirium, isoflurane and abeta
5) Confidence 0.39 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 17234824 Disease Relevance 0.85 Pain Relevance 0.37
Treatment of cells with DXM prior to TMZ appeared to significantly decrease the activation of caspase-3 (panel C, Fig. 6), indicating an inhibitory effect of DXM on TMZ induced caspase-3 activation.


Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 associated with dexamethasone
6) Confidence 0.28 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.31 Pain Relevance 0.31
Derivatives induced apoptosis was mediated by the cleavage and activation of caspase-9 and caspase-3, but not caspase 8, implicating the mitochondrial pathway for apoptosis induction.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 in cleavage associated with apoptosis
7) Confidence 0.26 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.35 Pain Relevance 0.12
Treatment with amygdalin increased expression of Bax, a pro-apoptotic protein, decreased expression of Bcl-2, an anti-apoptotic protein, and increased caspase-3 enzyme activity in DU145 and LNCaP prostate cancer cells.
Positive_regulation (increased) of Positive_regulation (increased) of caspase-3 associated with prostate cancer and apoptosis
8) Confidence 0.25 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.72 Pain Relevance 0.08
Here, we have shown that amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax.
Positive_regulation (induces) of Positive_regulation (activation) of caspase-3 in apoptotic cell associated with prostate cancer, apoptosis and death
9) Confidence 0.25 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.62 Pain Relevance 0.07
We therefore set out to assess effects of extracellular calcium concentration on isoflurane-induced caspase-3 activation in H4 human neuroglioma cells stably transfected to express human full-length APP (H4-APP cells).
Positive_regulation (isoflurane-induced) of Positive_regulation (activation) of caspase-3 associated with isoflurane
10) Confidence 0.18 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.62 Pain Relevance 0.40
Aggregation of pro-caspase-8 leads to its auto-activation and subsequent activation of effector caspases such as caspase-3 [26].
Positive_regulation (leads) of Positive_regulation (activation) of caspase-3
11) Confidence 0.17 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.37 Pain Relevance 0.04
Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 associated with isoflurane
12) Confidence 0.17 Published 2008 Journal J. Neurosci. Section Title Doc Link 18434534 Disease Relevance 0.62 Pain Relevance 0.37
Memantine (20 mg/kg, i.p.) reduced isoflurane-induced caspase-3 activation in brain tissue of naive mice.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 in brain associated with isoflurane
13) Confidence 0.17 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.73 Pain Relevance 0.74
Memantine (4 microM) inhibited isoflurane-induced elevations in cytosolic calcium levels and attenuated isoflurane-induced caspase-3 activation, apoptosis, and cell viability.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 associated with isoflurane and apoptosis
14) Confidence 0.17 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.73 Pain Relevance 0.73
Results from this study suggest that FLX may exhibit apoptotic effect against ovarian cancer cell lines by inducing the mitochondrial membrane permeability change, which leads to cytochrome c release and subsequent caspase-3 activation, through reactive oxygen species-dependent activation of NF-kappaB.
Positive_regulation (leads) of Positive_regulation (activation) of caspase-3 associated with ovarian cancer, apoptosis and fluoxetine
15) Confidence 0.16 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20050848 Disease Relevance 0.70 Pain Relevance 0.56
M) for 24 h, caspase-3 activity was about 30,000 arbitrary units after 8 h and about 43,000 after 24 h in cells treated with Mcl-1 siRNA vs. 16,000 after 8 h and 24,000 after 24 h in cells treated with control siRNA (Fig. 5B).
Positive_regulation (with) of Positive_regulation (activity) of caspase-3
16) Confidence 0.14 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.69 Pain Relevance 0
M) for 24 h, caspase-3 activity was about 30,000 arbitrary units after 8 h and about 43,000 after 24 h in cells treated with Mcl-1 siRNA vs. 16,000 after 8 h and 24,000 after 24 h in cells treated with control siRNA (Fig. 5B).
Positive_regulation (was) of Positive_regulation (activity) of caspase-3
17) Confidence 0.14 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.65 Pain Relevance 0
M ErPC led to appearance of the cleaved PARP fragment (89 kDa), indicative for caspase-3 activation.
Positive_regulation (indicative) of Positive_regulation (activation) of caspase-3
18) Confidence 0.14 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1475859 Disease Relevance 1.01 Pain Relevance 0
In the present study, activation of caspase-3 was increased when cells were treated with triptolide.
Positive_regulation (increased) of Positive_regulation (activation) of caspase-3
19) Confidence 0.13 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.88 Pain Relevance 0.12
increases of caspase 3 activation.
Positive_regulation (activation) of Positive_regulation (increases) of caspase 3
20) Confidence 0.13 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510951 Disease Relevance 0.14 Pain Relevance 0.07

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