INT10275

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il1b, Penk) extracellular space (Il1b) aging (Il1b)
Anatomy Link Frequency
astrocytes 2
Il1b (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 98.12 Very High Very High Very High
Central nervous system 8 97.28 Very High Very High Very High
cytokine 2 92.56 High High
agonist 2 90.32 High High
Glutamate 2 86.24 High High
adenocard 2 78.24 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 4 98.84 Very High Very High Very High
Injury 6 97.88 Very High Very High Very High
Disease 2 86.80 High High
Gliosis 2 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proenkephalin mRNA expression was stimulated by IL-1 beta in a time- and concentration-dependent manner, being maximal with 5 U/ml IL-1 beta at 4 h.
IL-1 beta Positive_regulation (stimulated) of Gene_expression (expression) of Proenkephalin
1) Confidence 0.49 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.26 Pain Relevance 0.49
These results suggest that enhanced proenkephalin gene expression in astrocytes by IL-1 beta may be important in neuroimmune interactions and in trauma-induced CNS injury or stress.
IL-1 beta Positive_regulation (enhanced) of Gene_expression (expression) of proenkephalin in astrocytes associated with stress, injury and central nervous system
2) Confidence 0.46 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.49 Pain Relevance 0.34

General Comments

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