INT102751

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 3.06
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
poly 2
nose 1
polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 25 99.98 Very High Very High Very High
Inflammation 33 93.32 High High
Analgesic 2 60.00 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 134 98.36 Very High Very High Very High
Influenza Virus Infection 128 96.92 Very High Very High Very High
Death 11 96.64 Very High Very High Very High
Apoptosis 18 96.40 Very High Very High Very High
Overdose 1 93.76 High High
INFLAMMATION 33 93.32 High High
Infection 96 93.28 High High
Trepenoma Infection 111 88.32 High High
Hepatocellular Cancer 3 82.24 Quite High
Liver Failure 1 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen triggered the release of cytochrome c from mitochondria into the cytosol, activation of caspase-3, 8, and 9, cleavage of poly(ADP-ribose) polymerase, and degradation of lamin B1 and DNA.
Positive_regulation (activation) of polymerase in poly associated with paracetamol
1) Confidence 0.10 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12005112 Disease Relevance 0.67 Pain Relevance 0.92
According to Western blot analysis, treatment with AAP increased the level of poly(ADP-ribose) polymerase (PARP) fragments in cells compared with that in control cells; however, caspase-3, a critical signaling molecule in apoptosis, was not activated after AAP overdose.
Positive_regulation (increased) of polymerase in poly associated with paracetamol, apoptosis and overdose
2) Confidence 0.09 Published 2007 Journal Toxicology Section Abstract Doc Link 17169476 Disease Relevance 0.85 Pain Relevance 0.84
Minigenome assay for polymerase activity.
Positive_regulation (assay) of polymerase
3) Confidence 0.04 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.25 Pain Relevance 0
At least in the case of G2, it appears that the PB2 D87N mutation may play a role in viral replication and that this mutation functions by increasing polymerase activity.
Positive_regulation (increasing) of polymerase
4) Confidence 0.04 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.05 Pain Relevance 0
The G1 RNP complex, carrying the PA L295P mutation, showed ~20% more polymerase activity than TN/560 at 37°C (and comparable activities at 33°C and 39°C) (Fig. 3A).
Positive_regulation (more) of polymerase
5) Confidence 0.04 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.21 Pain Relevance 0
The polymerase acidic protein mutation increased polymerase activity at 37°C, and the hemagglutinin change affected binding of the virus to ?
Positive_regulation (increased) of polymerase
6) Confidence 0.04 Published 2010 Journal mBio Section Abstract Doc Link PMC2993010 Disease Relevance 0.55 Pain Relevance 0
In this study, a single mutation, PB2 D87N, was responsible for increased G2 RNP polymerase activity at the lower temperature (33°C) found in the mammalian airway and, therefore, probably contributed to better replication in the nose, significantly elevated inflammation, or more efficient transmission.
Positive_regulation (increased) of polymerase in nose associated with inflammation
7) Confidence 0.04 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.31 Pain Relevance 0.05
These findings indicated that the increased mouse virulence attributed to avian PB1 in the WY03 genetic background (r1/3/5/7/8) may not directly result from stimulation of the polymerase activities of the RNP.
Positive_regulation (stimulation) of polymerase
8) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0 Pain Relevance 0
A 10µl sample was tested in duplicate using a real-time PCR that targets the DNA polymerase I gene of Tp (polA).
Positive_regulation (targets) of polymerase
9) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.09 Pain Relevance 0
The RT-PCR conditions for the one-step SYBR green I RT-PCR consist of a 20-min reverse transcription step at 44°C and then 2 min of Taq polymerase activation at 94°C, followed by 40 cycles of PCR at 94°C for15 seconds (denaturation), 60°C for 1 min (annealing and extension).
Positive_regulation (activation) of polymerase
10) Confidence 0.01 Published 2010 Journal Virol J Section Body Doc Link PMC2827404 Disease Relevance 0 Pain Relevance 0
Human mitochondrial transcription requires bacteriophage-related RNA polymerase, POLRMT, mtDNA-binding protein, h-mtTFA/TFAM, and two transcription factors/rRNA methyltransferases, h-mtTFB1 and h-mtTFB2.
Positive_regulation (requires) of polymerase
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.07 Pain Relevance 0

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