INT102758

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Context Info
Confidence 0.51
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 1.13
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Abl1) nucleus (Abl1) kinase activity (Abl1)
cytoplasm (Abl1)
Anatomy Link Frequency
neurons 1
Abl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 186 99.84 Very High Very High Very High
Central nervous system 6 81.52 Quite High
long-term potentiation 30 78.48 Quite High
depression 48 76.76 Quite High
Hippocampus 24 62.60 Quite High
headache 1 25.00 Low Low
Pyramidal cell 12 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 12 99.16 Very High Very High Very High
Apoptosis 2 98.24 Very High Very High Very High
Myeloid Leukemia 2 97.12 Very High Very High Very High
Chronic Myeloid Leukemia 2 92.96 High High
Genetic Translocation 6 90.20 High High
Targeted Disruption 12 86.44 High High
Depression 48 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STI571 is a potent inhibitor of Abl kinase as well as PDGF?
Negative_regulation (inhibitor) of Abl kinase
1) Confidence 0.51 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.49 Pain Relevance 0.16
These observations show that ROCK is required for Abl-mediated changes in the actin cytoskeleton that leads to inhibition of NMDA currents and that Abl-mediated inhibition of NMDA receptor currents requires RhoGTPase and ROCK signaling (Figure 5).
Negative_regulation (inhibition) of Abl-mediated associated with nmda receptor
2) Confidence 0.37 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.25
Furthermore, the ROCK inhibitor attenuated Abl-induced decreases in NMDA-evoked currents.
Negative_regulation (decreases) of Abl
3) Confidence 0.37 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.28
Furthermore, the ROCK inhibitor attenuated Abl-induced decreases in NMDA-evoked currents.
Negative_regulation (attenuated) of Abl
4) Confidence 0.37 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.28
We demonstrate that active Abl kinase inhibits NMDA currents in isolated hippocampal neurons.
Negative_regulation (inhibits) of Abl kinase in neurons
5) Confidence 0.37 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.09 Pain Relevance 0.09
Abl inhibition of NMDA currents is blocked by the ROCK inhibitor Y-27632
Negative_regulation (inhibition) of Abl
6) Confidence 0.37 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.05
Imatinib, an orally administered inhibitor of the breakpoint cluster region-Abl tyrosine kinase, is capable of blocking proliferation and inducing apoptosis in CML cell lines.
Negative_regulation (inhibitor) of region-Abl associated with myeloid leukemia and apoptosis
7) Confidence 0.01 Published 2002 Journal Clin. Cancer Res. Section Abstract Doc Link 12006504 Disease Relevance 0.55 Pain Relevance 0

General Comments

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