INT102776

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.55
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
melanocytes 1
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 21 100.00 Very High Very High Very High
cytokine 24 99.50 Very High Very High Very High
Inflammation 30 97.52 Very High Very High Very High
Arthritis 2 69.92 Quite High
antagonist 4 25.00 Low Low
cINOD 2 25.00 Low Low
psoriasis 19 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 5 98.00 Very High Very High Very High
INFLAMMATION 32 97.52 Very High Very High Very High
Disease 16 97.00 Very High Very High Very High
Staphylococcus Infection 1 84.00 Quite High
Cancer 8 81.04 Quite High
Wound Healing 2 80.00 Quite High
Pulmonary Disease 2 79.84 Quite High
Metastasis 2 73.84 Quite High
Sepsis 2 72.40 Quite High
Systemic Lupus Erythematosus 3 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent data implicate CXCL8 (old name, IL-8), CXCL10 (old name, IP-10) (both CXC chemokines) and CCL2 (old name, MCP-1) (a CC chemokine) in veterinary infections, inflammatory diseases or reproduction.
Spec (implicate) Phosphorylation (implicate) of CCL2 associated with chemokine, inflammation, disease and infection
1) Confidence 0.65 Published 2002 Journal Vet. Immunol. Immunopathol. Section Abstract Doc Link 12007879 Disease Relevance 0.95 Pain Relevance 0.39
When stimulated by TLR ligands, human melanocytes can: (1) release IL-6 and IL-8 cytokines, (2) enhance chemokine (CCL2, CCL3, and CCL5) mRNA production, (3) upregulate phosphorylated I?
Phosphorylation (phosphorylated) of CCL2 in melanocytes associated with chemokine and cytokine
2) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.61 Pain Relevance 0.17

General Comments

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