INT102801

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Context Info
Confidence 0.51
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR2) signal transduction (ESR2) mitochondrion (ESR2)
nucleus (ESR2) enzyme binding (ESR2) DNA binding (ESR2)
Anatomy Link Frequency
endothelial cells 1
ESR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 2 100.00 Very High Very High Very High
Morphine 4 99.52 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UNLABELLED: Human vascular endothelial cells express the estrogen receptor-beta (ER-beta), which can be modulated by the opiate alkaloid morphine.
Regulation (modulated) of estrogen receptor-beta in endothelial cells associated with opiate and morphine
1) Confidence 0.51 Published 2002 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 12011792 Disease Relevance 0 Pain Relevance 0.27
OBJECTIVES: To determine if morphine is capable of down regulating the ER-beta receptor in a similar fashion as the mu opiate receptor since they are both coupled to constitutive nitric oxide synthase derived nitric oxide release.
Regulation (regulating) of ER-beta
2) Confidence 0.22 Published 2002 Journal Neuro Endocrinol. Lett. Section Body Doc Link 12011792 Disease Relevance 0 Pain Relevance 0

General Comments

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