INT102813

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2011
Negated 6
Speculated 3
Reported most in Body
Documents 25
Total Number 31
Disease Relevance 25.95
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 4
epithelial cells 4
T24 4
lymph node 2
vulva 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 99.56 Very High Very High Very High
cINOD 35 83.28 Quite High
cytokine 20 77.96 Quite High
Inflammation 48 77.48 Quite High
COX2 53 75.00 Quite High
aspirin 13 50.00 Quite Low
Somatostatin 5 23.36 Low Low
Bile 2 7.68 Low Low
COX-2 inhibitor 10 5.20 Low Low
interstitial cystitis 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1011 100.00 Very High Very High Very High
Apoptosis 379 100.00 Very High Very High Very High
Breast Cancer 214 99.48 Very High Very High Very High
Malignant Neoplastic Disease 87 99.48 Very High Very High Very High
Bladder Cancer 186 99.08 Very High Very High Very High
Conjunctiva Disease 44 98.92 Very High Very High Very High
Metastasis 79 98.60 Very High Very High Very High
Carcinoma 122 98.36 Very High Very High Very High
Hypoxia 7 98.28 Very High Very High Very High
Endometroid Carcinoma 93 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antitumor effects thereby depend on the expression level of transduced p53 and on the integrity in p53-mediated cascades in the target tumors.
Regulation (depend) of Gene_expression (expression) of p53 associated with cancer
1) Confidence 0.59 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.63 Pain Relevance 0
DNA damage and hypoxia resulted in increased p53 protein accumulation indicating that PDF expression may be controlled by cellular levels of p53.
Regulation (controlled) of Gene_expression (levels) of p53 associated with hypoxia
2) Confidence 0.43 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.86 Pain Relevance 0.23
However, there was no association between COX-2 or p53 expression and survival. p53 expression did not correlate with COX-2 expression.
Neg (no) Regulation (association) of Gene_expression (expression) of p53
3) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721998 Disease Relevance 1.02 Pain Relevance 0
However, there was no association between COX-2 or p53 expression and tumor stage, status of lymph node, or distant metastasis.
Neg (no) Regulation (association) of Gene_expression (expression) of p53 in lymph node associated with cancer and metastasis
4) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.88 Pain Relevance 0
However, there was no association between p53 expression and survivial.
Neg (no) Regulation (association) of Gene_expression (expression) of p53
5) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.82 Pain Relevance 0
Correlation between COX-2 or p53 expression and clinicopathological variables
Regulation (Correlation) of Gene_expression (expression) of p53
6) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.83 Pain Relevance 0
Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?
Regulation (using) of Gene_expression (expression) of p53 associated with endometroid carcinoma
7) Confidence 0.39 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 1.26 Pain Relevance 0
Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?
Regulation (using) of Gene_expression (expression) of p53 associated with endometroid carcinoma
8) Confidence 0.39 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.42 Pain Relevance 0
Several genes, including MDM2 and p14 AR, that regulate p53 levels have been shown to cause detectable levels of p53 in the absence of p53 mutation.
Regulation (regulate) of Gene_expression (levels) of p53
9) Confidence 0.39 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.10 Pain Relevance 0
In addition to the rarity of the tumor, the present case suggests the malignant potency of the tumor despite lack of bcl-2 and p53 expression, which has been known as a marker for malignancy of neuroendocrine tumors [2-5].


Regulation (lack) of Gene_expression (expression) of p53 associated with malignant neoplastic disease, neuroendocrine cancer, cancer and potency
10) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.30 Pain Relevance 0.05
The expression of caspase-3, Bcl-2, and p53 was evaluated by immunohistochemistry

Results

Regulation (evaluated) of Gene_expression (expression) of p53
11) Confidence 0.35 Published 2006 Journal Head Face Med Section Abstract Doc Link PMC1524725 Disease Relevance 1.38 Pain Relevance 0.11
In the present study, while 34.6% of tumors expressed p53, there was no correlation between p53 and survivin expression.
Neg (no) Regulation (correlation) of Gene_expression (expression) of p53 associated with cancer
12) Confidence 0.32 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 1.02 Pain Relevance 0
Moreover, in LoVo cells, exposure to NCX 4040 induced an increased expression of both pro-apoptotic protein p53 and NAG-1, starting from a 2-hour and 4-hour drug exposure, respectively, whereas in LRWZ, p53 expression was unaffected and NAG-1 expression was induced after an exposure of 8 hours and was still detectable after 48 hours (Fig. 5A and 5B).
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of p53 in LoVo associated with apoptosis
13) Confidence 0.28 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 0.95 Pain Relevance 0
Modulators of apoptosis such as p53, TGF?
Regulation (Modulators) of Gene_expression (apoptosis) of p53 associated with apoptosis
14) Confidence 0.24 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.79 Pain Relevance 0
No expression of p53 and p16INK4A was detected in normal epithelium of the vulva [20].
Regulation (detected) of Gene_expression (expression) of p53 in vulva
15) Confidence 0.22 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.68 Pain Relevance 0
To elucidate the mechanisms of ALA induced apoptosis, we examined its effect on p53 expression.
Spec (examined) Regulation (effect) of Gene_expression (expression) of p53 associated with apoptosis
16) Confidence 0.21 Published 2002 Journal BMC Cancer Section Abstract Doc Link PMC101407 Disease Relevance 0.51 Pain Relevance 0
In this study, we investigated particularly the effect of 100 microM NS-398 on p53 and p21 expression, caspase activities and nuclear factor-kappaB (NF-kappaB).
Spec (investigated) Regulation (effect) of Gene_expression (expression) of p53
17) Confidence 0.21 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 12012007 Disease Relevance 0.76 Pain Relevance 0.17
However, even in a meta-analysis of more than 9,000 breast cancer patients, the prognostic value of the p53 overexpression appeared weak.100 Conversely, sequencing studies have shown strong prognostic significance of p53 mutations in breast cancer.
Regulation (value) of Gene_expression (overexpression) of p53 associated with breast cancer
18) Confidence 0.18 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.92 Pain Relevance 0
Except epithelium surface, no p53 and ras expression was detected in differentiating epithelial cells.


Regulation (detected) of Gene_expression (expression) of p53 in epithelial cells
19) Confidence 0.17 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.50 Pain Relevance 0
APF increases p53 tumor suppressor gene expression via CKAP4 in T24 cells
Regulation (via) of Gene_expression (expression) of p53 tumor suppressor gene in T24 associated with cancer
20) Confidence 0.17 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.35 Pain Relevance 0

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