INT102814

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 46
Total Number 46
Disease Relevance 28.54
Pain Relevance 6.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
monocytes 7
cleavage 2
PGE2 2
fibroblasts 1
ganglion cell 1
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 20 100.00 Very High Very High Very High
COX-2 inhibitor 5 99.76 Very High Very High Very High
antagonist 47 99.66 Very High Very High Very High
nMDA receptor 8 99.28 Very High Very High Very High
dexamethasone 65 99.18 Very High Very High Very High
cINOD 31 97.88 Very High Very High Very High
opiate 3 97.40 Very High Very High Very High
lidocaine 19 97.28 Very High Very High Very High
Arthritis 8 96.56 Very High Very High Very High
Morphine 8 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 20 100.00 Very High Very High Very High
Apoptosis 1189 99.92 Very High Very High Very High
Pancreatic Cancer 26 99.44 Very High Very High Very High
Shock 15 99.28 Very High Very High Very High
Osteogenic Sarcomas 4 99.24 Very High Very High Very High
Death 218 99.12 Very High Very High Very High
Repression 16 98.56 Very High Very High Very High
Leukemia 65 97.94 Very High Very High Very High
INFLAMMATION 238 97.68 Very High Very High Very High
Breast Cancer 62 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potent inhibition (>70%) of apoptosis by an inhibitor of caspase-3 as well as co-localization of active caspase-3 and DNA fragmentation in microglia or neurons treated with morphine indicated that caspase-3 is involved in the execution phase of morphine-induced apoptosis.
Negative_regulation (inhibitor) of caspase-3 in microglia associated with apoptosis and morphine
1) Confidence 0.43 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015209 Disease Relevance 0.97 Pain Relevance 0.98
The potentiating actions of these NSAIDs were not suppressed by treatment with phenyl-N-butyl-nitrone, a radical scavenger; N-acetyl-l-cysteine, an antioxidant; Ac-DEVD-CHO, a selective caspase-3 inhibitor; or 2-chloro-5-nitro-N-phenylbenzamide (GW9662), a selective antagonist of peroxisome proliferator-activated receptor gamma.
Negative_regulation (inhibitor) of caspase-3 associated with antagonist and cinod
2) Confidence 0.42 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15131242 Disease Relevance 0.57 Pain Relevance 0.72
The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells.
Negative_regulation (decrease) of caspase-3 associated with osteogenic sarcomas and apoptosis
3) Confidence 0.38 Published 2002 Journal Int. J. Oncol. Section Title Doc Link 12012007 Disease Relevance 0.78 Pain Relevance 0.19
We found a correlation between p53, p21 mRNA expression and NF-kappaB activation and, we observed an induction of heat shock protein 70 expression with a large decrease in caspase-3 activity after 100 microM NS-398 treatment.
Negative_regulation (decrease) of caspase-3 associated with shock
4) Confidence 0.38 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 12012007 Disease Relevance 0.74 Pain Relevance 0.14
The inhibitor of caspase-3 blocked PARP-1 cleavage activity and protected against MEF-induced apoptotic cell death.
Negative_regulation (inhibitor) of caspase-3 in apoptotic cell associated with apoptosis and death
5) Confidence 0.38 Published 2004 Journal Life Sci. Section Abstract Doc Link 15350819 Disease Relevance 0.83 Pain Relevance 0.23
A pan-caspase inhibitor and a caspase-3 inhibitor blocked DNA ladder formation followed by the reduction of cell death.
Negative_regulation (inhibitor) of caspase-3 associated with death
6) Confidence 0.33 Published 2005 Journal Biomed. Res. Section Abstract Doc Link 16415504 Disease Relevance 0.90 Pain Relevance 0.60
A pan-caspase inhibitor and a caspase-3 inhibitor blocked DNA ladder formation followed by the reduction of cell death.
Negative_regulation (inhibitor) of caspase-3 associated with death
7) Confidence 0.33 Published 2005 Journal Biomed. Res. Section Abstract Doc Link 16415504 Disease Relevance 0.90 Pain Relevance 0.60
Induction of apoptosis was monitored by DNA ladder formation, reduction of mitochondrial transmembrane potential (DeltaPsim), caspase-3 activity and nuclear morphology.
Negative_regulation (reduction) of caspase-3 associated with apoptosis
8) Confidence 0.33 Published 2005 Journal Biomed. Res. Section Abstract Doc Link 16415504 Disease Relevance 0.76 Pain Relevance 0.50
Both the cytotoxic effects and apoptotic characteristics induced by platycodon D treatment were significantly inhibited by z-DEVD-fmk, a caspase-3 inhibitor, which demonstrates the important role that caspase-3 plays in the observed cytotoxic effect.
Negative_regulation (inhibitor) of caspase-3 associated with apoptosis
9) Confidence 0.32 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.90 Pain Relevance 0.15
Inhibition of caspase-3 prevented the activation of caspase 8, while the inhibition of caspase-9 inhibitor blocked activation of both caspase 3 and 8 by the derivatives.
Negative_regulation (Inhibition) of caspase-3
10) Confidence 0.31 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.14 Pain Relevance 0
Thus, pretreatment of cells with DXM prior to treatment with TMZ appeared to decrease the upregulation of caspase-3 activity.
Negative_regulation (decrease) of caspase-3 associated with dexamethasone
11) Confidence 0.26 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0 Pain Relevance 0.25
Inhibitors of caspase-3 and caspase-9 and cyclosporin A, a mitochondrial membrane potential stabilizer, attenuated derivative induced apoptosis.
Negative_regulation (Inhibitors) of caspase-3 associated with apoptosis
12) Confidence 0.22 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.26 Pain Relevance 0.11
These results indicate that mitochondrial-mediated apoptosis in HepG2 cells, triggered by DLS, is predominantly associated with down-regulation of the Bcl-2/Bax expression ratio.Fig. 3Western blot analysis of the expression levels of caspase3, caspase9, Bcl-2, Bax, caspase8 and DR5 with the treatment of DLS for 24 h (All the experiments were repeated four times.)Fig. 4Bcl-2, Bax, DR5 protein expression in HepG2 cells (×200). a, c, e Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment without DLS. b, d, f Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment with 25 ?
Negative_regulation (regulation) of caspase3 associated with apoptosis
13) Confidence 0.21 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.64 Pain Relevance 0
Activation of caspase-8 is required for death receptor-induced apoptosis [36, 37].Correspondingly, the reduction of Procaspase3, 8 and 9 in DLS-treated HepG2 cells could indicate that the caspases were activated since the activation of caspase activity results from cleavage of procaspases.
Negative_regulation (reduction) of Procaspase3 in cleavage associated with apoptosis and death
14) Confidence 0.18 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 1.29 Pain Relevance 0.04
We also show for the first time that the NMDA receptor partial antagonist, memantine, can prevent isoflurane-induced caspase-3 activation and apoptosis in vivo and in vitro.
Negative_regulation (prevent) of caspase-3 associated with antagonist, nmda receptor, isoflurane and apoptosis
15) Confidence 0.15 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.42 Pain Relevance 0.69
Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.
Negative_regulation (attenuated) of caspase-3 associated with isoflurane
16) Confidence 0.15 Published 2008 Journal J. Neurosci. Section Title Doc Link 18434534 Disease Relevance 0.69 Pain Relevance 0.40
was caspase-3 dependent, as treatment with a caspase-3 inhibitor completely
Negative_regulation (inhibitor) of caspase-3
17) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.80 Pain Relevance 0
Our results showed those inhibitors of not only caspase-3, but also caspases-8 and -9 suppressed triptolide induced-DNA fragmentation in RSF.
Negative_regulation (inhibitors) of caspase-3
18) Confidence 0.11 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.90 Pain Relevance 0.05
These pro-apoptotic genes do not affect the inhibition of caspase-3 by Shigella, especially since cytochrome c release occurs in the presence of STS in infected cells [2].
Negative_regulation (inhibition) of caspase-3 associated with apoptosis
19) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.38 Pain Relevance 0
Z-DEVD-FMK (a caspase-3 inhibitor), Z-IETD-FMK (a caspase-8 inhibitor) and Z-LEHD-FMK (a caspase-9 inhibitor) were purchased from R&D Systems, Inc.
Negative_regulation (inhibitor) of caspase-3
20) Confidence 0.08 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.52 Pain Relevance 0.13

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