INT102816

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 7.08
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TCEAL1)
Anatomy Link Frequency
lung 2
bladder 1
uterine 1
adipocyte 1
TCEAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 99 97.72 Very High Very High Very High
antagonist 11 95.20 Very High Very High Very High
palliative 3 95.04 Very High Very High Very High
COX-2 inhibitor 19 87.52 High High
withdrawal 3 79.16 Quite High
cINOD 27 77.32 Quite High
cytokine 9 74.48 Quite High
Inflammation 87 74.08 Quite High
metalloproteinase 74 50.00 Quite Low
ischemia 1 33.28 Quite Low
Disease Link Frequency Relevance Heat
Hyperplasia 4 99.90 Very High Very High Very High
Reprotox - General 3 1 99.54 Very High Very High Very High
Lung Cancer 27 99.08 Very High Very High Very High
Bladder Cancer 4 98.84 Very High Very High Very High
Pancreatic Cancer 3 98.46 Very High Very High Very High
Shock 1 98.44 Very High Very High Very High
Apoptosis 76 97.88 Very High Very High Very High
Colon Cancer 42 96.36 Very High Very High Very High
Carcinoid 9 95.88 Very High Very High Very High
Breast Cancer 81 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, treatment with ZM336372 led to a marked suppression of cellular proliferation and induction of the cell cycle inhibitors p21 and p18.
Positive_regulation (induction) of p21 associated with hyperplasia
1) Confidence 0.37 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15956248 Disease Relevance 0.92 Pain Relevance 0.10
Terminal adipocyte differentiation is accompanied by expression of proteins that repress RNA expression, along with induction of p21, leading to irreversible loss of proliferative potential [140, 143].
Positive_regulation (induction) of p21 in adipocyte
2) Confidence 0.11 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.73 Pain Relevance 0.04
We found a correlation between p53, p21 mRNA expression and NF-kappaB activation and, we observed an induction of heat shock protein 70 expression with a large decrease in caspase-3 activity after 100 microM NS-398 treatment.
Positive_regulation (activation) of p21 associated with shock
3) Confidence 0.11 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 12012007 Disease Relevance 0.76 Pain Relevance 0.15
agonist treatment in human pancreatic cancer and bladder cancer cell lines resulted in G1 cell cycle arrest secondary to p21 induction [164, 165].
Positive_regulation (induction) of p21 in bladder associated with bladder cancer, pancreatic cancer and agonist
4) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.78 Pain Relevance 0.22
ligand PGJ2 induces both CDK p21 and the proapoptotic Bax but downregulates the anti-apoptotic Bcl-xL [163].
Positive_regulation (induces) of p21 associated with apoptosis
5) Confidence 0.07 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.79 Pain Relevance 0.18
Both NS-398 and nimesulide induced p21 gene promoter activity in non-small cell lung cancer cells but COX-2 siRNA did not affect the expression of p21 [35].
Positive_regulation (induced) of p21 in lung associated with lung cancer
6) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.96 Pain Relevance 0.12
Further, PTTG-1 overexpression in the human lung cancer cell line A549 inhibited the cell growth via activation of p21 [20].
Positive_regulation (activation) of p21 in lung associated with lung cancer
7) Confidence 0.04 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.28 Pain Relevance 0
In one study on the inhibition of uterine leiomyoma cells, Tranilast also induced p21 and p53 [55].
Positive_regulation (induced) of p21 in uterine associated with reprotox - general 3
8) Confidence 0.01 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.87 Pain Relevance 0.16

General Comments

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