INT102836

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 11.27
Pain Relevance 5.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
bridge 1
PAG 1
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 347 100.00 Very High Very High Very High
depression 155 99.98 Very High Very High Very High
cva 10 99.96 Very High Very High Very High
Neurosurgical lesion 12 99.74 Very High Very High Very High
rheumatoid arthritis 140 99.44 Very High Very High Very High
b2 receptor 7 99.20 Very High Very High Very High
Potency 2 98.40 Very High Very High Very High
Thalamotomy 27 98.20 Very High Very High Very High
Osteoarthritis 56 97.52 Very High Very High Very High
Nucleus accumbens 24 90.56 High High
Disease Link Frequency Relevance Heat
Depression 166 99.98 Very High Very High Very High
Cv General 4 Under Development 3 99.96 Very High Very High Very High
Rheumatoid Arthritis 140 99.44 Very High Very High Very High
Convulsion 5 99.16 Very High Very High Very High
Disease 379 99.08 Very High Very High Very High
Infection 8 98.92 Very High Very High Very High
Dyskinesias 117 98.80 Very High Very High Very High
Syndrome 234 98.56 Very High Very High Very High
Hypokinesia 12 98.08 Very High Very High Very High
Osteoarthritis 56 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DBS was associated with changes in the metabolic activity of cortical and limbic circuits implicated in the pathogenesis of depression.
DBS Binding (associated) of associated with depression and deep brain stimulation
1) Confidence 0.38 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.41 Pain Relevance 0.46
Laboratory findings for anti-rLRP2 autoAb+ and autoAb- patients with RA
LRP2 Binding (findings) of associated with rheumatoid arthritis
2) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.04 Pain Relevance 0.34
Instead, rLRP2-F5 was recognized by 9 (75%) of the 12 anti-rLRP2 autoAb+ serum samples, and recognition of other fragments was not more than 25% (Table 1).
LRP2 Binding (recognized) of
3) Confidence 0.35 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.95 Pain Relevance 0.27
Further, the F4, F5, and F6 regions corresponded to the entire fourth LDLR domain of LRP2, which is thought to be a ligand-binding region (see Fig. 1).
LRP2 Binding (binding) of
4) Confidence 0.34 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.99 Pain Relevance 0.27
Multiple epitopes on LRP2 were recognized by most of the anti-LRP2+ serum samples.
LRP2 Binding (recognized) of
5) Confidence 0.34 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165049 Disease Relevance 1.41 Pain Relevance 0.29
Twenty patients with TRD underwent serial assessments before and after DBS of the subcallosal cingulate gyrus.
DBS Binding (underwent) of associated with deep brain stimulation and depression
6) Confidence 0.29 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.46 Pain Relevance 0.46
METHODS AND RESULTS: 16 patients undergoing DBS of the rostral PAG for chronic neuropathic pain were investigated post-operatively to determine whether PAG stimulation would alter HRV, and the subjects' perception of pain.
DBS Spec (determine) Binding (undergoing) of in PAG
7) Confidence 0.28 Published 2010 Journal Exp. Neurol. Section Body Doc Link 20178783 Disease Relevance 0 Pain Relevance 0
Despite their therapeutic promise for TS and apparent advantages compared with neurosurgical lesion procedures, DBS strategies also can be associated with a number of deleterious side effects and complications.
DBS Binding (associated) of associated with neurosurgical lesion, deep brain stimulation and syndrome
8) Confidence 0.15 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.74 Pain Relevance 0.48
The affinity of (S)-14 g for the human B2 receptor suggested that it may be a hydrophobic interaction with the ethane bridge of the DBS moiety that accounts for the increased potency of compounds (S)-14d,e and 19b,c at this receptor, by favoring a binding mode inaccessible to the unsubstituted diphenylmethyl derivative, (S)-4.
DBS Binding (interaction) of in bridge associated with b2 receptor and potency
9) Confidence 0.13 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 12014954 Disease Relevance 0.09 Pain Relevance 0.58
While certain adverse events are common to both lesion and DBS procedures, such as intracerebral hemorrhage1 and the development of surgery-related infection or seizures (Hardesty and Sackheim 2007), others are unique to DBS.
DBS Binding (unique) of associated with convulsion, deep brain stimulation and infection
10) Confidence 0.12 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.76 Pain Relevance 0.47
Diederich and colleagues (2005) provide up to fourteen months of follow-up data regarding their patient with bilateral DBS of the posteroventrolateral GPi.
DBS Binding (patient) of associated with deep brain stimulation
11) Confidence 0.12 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.80 Pain Relevance 0.37
Bradykinesia improved more in the STN group when compared to GPi stimulation (Anderson et al 2003), and STN DBS was associated to a greater decrease in levodopa dosage (Rodriguez-Oroz et al 2005), but more severe speech impairment, postural instability, and cognitive decline (Anderson et al 2003; Rodriguez-Oroz et al 2005).
DBS Binding (associated) of associated with cognitive disorder, deep brain stimulation and hypokinesia
12) Confidence 0.07 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.88 Pain Relevance 0.45
Although one patient in the DBS group died after an intracerebral hemorrhage, DBS was associated with significantly fewer complications than thalamotomy.
DBS Binding (associated) of associated with deep brain stimulation, cv general 4 under development, thalamotomy and cva
13) Confidence 0.06 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.25 Pain Relevance 0.79
The “off” UPDRS motor score has been reported to improve by 34% to 60% and the UPDRS ADL score by 30%–50% in patients undergoing STN or GPi DBS.
DBS Binding (undergoing) of associated with deep brain stimulation
14) Confidence 0.06 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.50 Pain Relevance 0.36

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