INT102839

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2002
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.30
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdc) nucleus (Pdc) cilium (Pdc)
cytoplasm (Pdc)
Anatomy Link Frequency
photoreceptor cell 4
retina 2
glial cell 1
B cells 1
NK cells 1
Pdc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 69 98.20 Very High Very High Very High
Multiple sclerosis 160 97.32 Very High Very High Very High
antagonist 6 97.12 Very High Very High Very High
cytokine 65 94.28 High High
Central nervous system 32 92.08 High High
Inflammatory response 10 91.64 High High
tolerance 11 87.92 High High
gABA 4 82.28 Quite High
Inflammation 67 81.68 Quite High
Glutamate receptor 5 78.88 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 30 99.42 Very High Very High Very High
Biliary Liver Cirrhosis 151 99.16 Very High Very High Very High
Disease 144 98.80 Very High Very High Very High
Death 22 98.20 Very High Very High Very High
Systemic Lupus Erythematosus 158 97.96 Very High Very High Very High
Retina Disease 40 97.36 Very High Very High Very High
Demyelinating Disease 177 97.32 Very High Very High Very High
Multiple Sclerosis 22 95.00 High High
Recurrence 12 94.48 High High
Central Nervous System Disease 27 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosducin (Phd), a protein that in retina regulates rhodopsin desensitization by controlling the activity of Gt beta gamma-dependent G-protein-coupled receptor kinases (GRKs), is present in very low levels in the CNS of mammals.
Gene_expression (present) of Phosducin in retina
1) Confidence 0.52 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015208 Disease Relevance 0 Pain Relevance 0.30
Phosducin (Phd), a protein that in retina regulates rhodopsin desensitization by controlling the activity of Gt beta gamma-dependent G-protein-coupled receptor kinases (GRKs), is present in very low levels in the CNS of mammals.
Gene_expression (present) of Phd in retina
2) Confidence 0.52 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015208 Disease Relevance 0 Pain Relevance 0.30
The production of the type I IFN by PDC in response to CpG is mediated through TLR9 which is specific for CpG-containing motifs [15].
Gene_expression (production) of PDC
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 1.12 Pain Relevance 0.04
The MLR assays were carried out in 96-well round-bottom microplates to ensure efficient PDC/B cell contact. pDCs were treated with E2 and/or CpG for 24 h and then B cells were implanted with PDC at the ratio of 1?
Gene_expression (implanted) of PDC in B cells
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
PDC–derived soluble factors including IFN-?
Gene_expression (derived) of PDC
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.08
Thus, we hypothesize that CCRL2 (e.g. expressed by mast cells and activated macrophages) binds to chemerin in vivo and presents the cell-signaling carboxyl-terminal domain of the chemoattractant to CMKLR1+ cells such as macrophages, pDC, and NK cells (Fig. 9).
Gene_expression (macrophages) of pDC in NK cells
6) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.32 Pain Relevance 0.07
CMKLR1 is expressed by circulating human plasmacytoid DC (pDC) but not by circulating or tissue mouse DC (20, 23).
Neg (not) Gene_expression (expressed) of pDC
7) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.15 Pain Relevance 0.46
It has been postulated that apoptotic cholangiocytes, unlike other apoptotic cell types, are a potential source of immunogenic PDC-E2 in patients with PBC [85].
Gene_expression (source) of PDC in apoptotic cell associated with biliary liver cirrhosis and apoptosis
8) Confidence 0.13 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.07 Pain Relevance 0.08
The pDC had a lower capacity to secrete IFN-?
Gene_expression (The) of pDC
9) Confidence 0.09 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.44 Pain Relevance 0.33
production by human pDC in vitro.
Gene_expression (production) of pDC
10) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 1.20 Pain Relevance 0.05
The late-expressed, previously characterized rod photoreceptor cell-enriched genes included rhodopsin (Rho; Molday and MacKenzie, 1983; Jan and Revel, 1974), guanylate cyclase activator 1a (Guca1a; Subbaraya et al., 1994), aryl hydrocarbon receptor-interacting protein-like 1 (Aipl1; van der Spuy et al., 2002), G protein ?
Gene_expression (expressed) of rod photoreceptor in photoreceptor cell
11) Confidence 0.08 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0.07
As expected for these rod photoreceptor and Müller glial cell genes, the signal intensity ratios for the bipolar cells to the rod photoreceptor and Müller glial cells were low, ranging from 0.004 to 0.051.
Gene_expression (expected) of rod photoreceptor in glial cell
12) Confidence 0.08 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
Nearest neighbor analysis was conducted by selecting neighbor genes whose temporal expression patterns, based on reliably assigned gene tag counts, displayed the minimal Euclidean distances to the pattern of a known bipolar cell or rod photoreceptor cell gene.
Gene_expression (expression) of rod photoreceptor in photoreceptor cell
13) Confidence 0.08 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
Fig. 1Temporal expression patterns of mouse bipolar cell and rod photoreceptor cell genes.
Gene_expression (expression) of rod photoreceptor in photoreceptor cell
14) Confidence 0.08 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0.08
This finding is consistent with clinical disease manifestations, where mutations (dominant or recessive) in rod photoreceptor cell-expressed genes commonly result in photoreceptor cell death and consequent RP.
Gene_expression (expressed) of rod photoreceptor in photoreceptor cell associated with disease, retina disease and death
15) Confidence 0.05 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.99 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox