INT10284

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 0.98
Pain Relevance 7.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ORM1) extracellular space (ORM1) extracellular region (ORM1)
Anatomy Link Frequency
plasma 6
ORM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 24 100.00 Very High Very High Very High
Paracetamol 9 100.00 Very High Very High Very High
qutenza 14 99.90 Very High Very High Very High
methadone 35 99.84 Very High Very High Very High
fortral 3 99.60 Very High Very High Very High
local anesthetic 9 99.42 Very High Very High Very High
Morphine 3 99.18 Very High Very High Very High
Codeine 3 98.98 Very High Very High Very High
narcan 3 98.80 Very High Very High Very High
cINOD 2 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.36 Very High Very High Very High
Disease 51 86.88 High High
Neuroblastoma 3 82.24 Quite High
Death 6 75.52 Quite High
Nociception 1 62.12 Quite High
Pain 3 61.08 Quite High
Cancer 35 55.16 Quite High
Acute Renal Failure 1 53.36 Quite High
Hepatic Insufficiency 1 47.84 Quite Low
Apoptosis 3 41.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma binding of imipramine and lidocaine, two drugs that bind predominantly to alpha-1 acid glycoprotein (AAG), and of diazepam and phenytoin, albumin-bound drugs, were studied in fresh human plasma.
alpha-1 acid glycoprotein Binding (bind) of in plasma associated with lidocaine
1) Confidence 0.48 Published 1985 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 3934087 Disease Relevance 0 Pain Relevance 0.37
Stereoselective separation was achieved with a silica column with covalently bound alpha 1-acid glycoprotein (Chiral-AGP) without any derivatization procedure.
Chiral-AGP Binding (bound) of
2) Confidence 0.47 Published 1992 Journal J. Chromatogr. Section Abstract Doc Link 1478983 Disease Relevance 0 Pain Relevance 0.46
Acetaminophen, phenobarbital, theophylline, and valproic acid showed negligible binding to alpha-1 acid glycoprotein.
alpha-1 acid glycoprotein Binding (binding) of associated with paracetamol
3) Confidence 0.47 Published 2004 Journal Ther Drug Monit Section Abstract Doc Link 14749548 Disease Relevance 0 Pain Relevance 0.49
Pathological states may affect the binding of drugs to plasma proteins, mainly human serum albumin and alpha 1 acid glycoprotein.
alpha 1 acid glycoprotein Binding (binding) of in plasma
4) Confidence 0.45 Published 1983 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6381335 Disease Relevance 0.29 Pain Relevance 0
The experiments carried out in this study with different ligands (homologous saturated fatty acids, indomethacin and lidocaine) show that: 1. ligand hydrophobicity affects the run of the dependence between the free ligand fraction and its total concentration, which confirms the importance of the hydration layer in the drug binding process,2. similar anomalous changes of the free drug fraction are observed not only for drugs interacting with different binding sites on human serum albumin (HSA), i.e. for propofol and indomethacin, but also for basic local anesthetic lidocaine which is known to bind to other plasma protein, alpha-1-acid glycoprotein (AGP).Therefore, the increase of the free drug fraction at its low total concentration does not appear to be an exclusive feature of propofol-HSA system.
alpha-1-acid glycoprotein Binding (bind) of in plasma associated with addiction, lidocaine and local anesthetic
5) Confidence 0.45 Published 2008 Journal Eur J Pharm Sci Section Abstract Doc Link 18644440 Disease Relevance 0 Pain Relevance 0.34
The results of the comet test and DNA fragmentation assay clearly suggest that capsaicin is able to induce DNA strand breaks already with concentrations in the range of 50 microM, corresponding to 29.3 microM of capsaicin not bound to alpha-1 acid glycoprotein.
alpha-1 acid glycoprotein Binding (bound) of associated with qutenza
6) Confidence 0.43 Published 1999 Journal Arch. Toxicol. Section Abstract Doc Link 10550483 Disease Relevance 0.43 Pain Relevance 1.04
Two classes of binding sites were identified with affinity and capacity constants consistent with binding to alpha-1-acid glycoprotein (AAG) and albumin.
alpha-1-acid glycoprotein Binding (binding) of
7) Confidence 0.37 Published 1988 Journal Pharm. Res. Section Abstract Doc Link 3247314 Disease Relevance 0 Pain Relevance 0.30
However, the data could not be relied upon since some anti-bacterials and non-steroidal anti-inflammatory drugs (NSAIDS), which are known to predominantly bind to HSA, were also found to bind to AGP.
AGP Binding (bind) of associated with inflammation and cinod
8) Confidence 0.36 Published 2006 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 16567134 Disease Relevance 0.10 Pain Relevance 0.10
The binding of acetaminophen, lidocaine, phenobarbital, phenytoin, theophylline, and valproic acid to human serum alpha-1 acid glycoprotein (orosomucoid) and to human serum albumin separately in vitro was investigated using equilibrium dialysis of the unlabeled drugs.
alpha-1 acid glycoprotein Binding (binding) of associated with paracetamol and lidocaine
9) Confidence 0.36 Published 2004 Journal Ther Drug Monit Section Abstract Doc Link 14749548 Disease Relevance 0 Pain Relevance 0.31
The binding of selected therapeutic drugs to human serum alpha-1 acid glycoprotein and to human serum albumin in vitro.
alpha-1 acid glycoprotein Binding (binding) of
10) Confidence 0.36 Published 2004 Journal Ther Drug Monit Section Title Doc Link 14749548 Disease Relevance 0 Pain Relevance 0.45
The experiments carried out in this study with different ligands (homologous saturated fatty acids, indomethacin and lidocaine) show that: 1. ligand hydrophobicity affects the run of the dependence between the free ligand fraction and its total concentration, which confirms the importance of the hydration layer in the drug binding process,2. similar anomalous changes of the free drug fraction are observed not only for drugs interacting with different binding sites on human serum albumin (HSA), i.e. for propofol and indomethacin, but also for basic local anesthetic lidocaine which is known to bind to other plasma protein, alpha-1-acid glycoprotein (AGP).Therefore, the increase of the free drug fraction at its low total concentration does not appear to be an exclusive feature of propofol-HSA system.
AGP Binding (bind) of in plasma associated with addiction, lidocaine and local anesthetic
11) Confidence 0.33 Published 2008 Journal Eur J Pharm Sci Section Abstract Doc Link 18644440 Disease Relevance 0 Pain Relevance 0.34
Less than 20% of naloxone, codeine, morphine, heroin, pentazocine, and diphenoxylate bound to alpha 1-AGP.
alpha 1-AGP Binding (bound) of associated with fortral, narcan, morphine and codeine
12) Confidence 0.33 Published 1981 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7193106 Disease Relevance 0 Pain Relevance 0.98
Isolated alpha 1-AGP bound dl-methadone more avidly.
alpha 1-AGP Binding (bound) of associated with methadone
13) Confidence 0.33 Published 1981 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7193106 Disease Relevance 0 Pain Relevance 1.01
Further, it was also observed that the protein binding obtained for the four gyrase inhibitors by HSA-HPLC method was not only similar to that obtained by ultra filtration in human plasma but was also in accordance with ex vivo and in vitro protein binding obtained for rat plasma after ultra filtration because these compounds predominantly bind to HSA The binding of several compounds to alpha1-acid glycoprotein (AGP), another important plasma protein, was also examined using AGP immobilized column.
AGP Spec (examined) Binding (binding) of in plasma
14) Confidence 0.31 Published 2006 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 16567134 Disease Relevance 0 Pain Relevance 0.09
Plasma albumin concentration and degree of binding do not correlate, but in normal hypoalbuminemic subjects the free fraction of dl-methadone correlates negatively with the concentration of alpha 1-acid glycoprotein (alpha 1-AGP), an acute-phase reactant protein.
alpha 1-AGP Neg (negatively) Binding (concentration) of in Plasma associated with methadone
15) Confidence 0.25 Published 1981 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7193106 Disease Relevance 0 Pain Relevance 0.90
The molecular determinants of LA binding to the major variant (F1*S) of human alpha1-acid glycoprotein (AGP) were therefore investigated spectrofluorometrically using whole AGP and a novel, F1*S variant-selective probe previously developed in our laboratory.
AGP Binding (binding) of
16) Confidence 0.18 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490577 Disease Relevance 0 Pain Relevance 0.53
Lapatinib is highly bound to albumin (>99%) and alpha-1 acid glycoprotein.
alpha-1 acid glycoprotein Binding (bound) of
17) Confidence 0.03 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.16 Pain Relevance 0.03

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