INT102842

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.48
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (YWHAQ) nucleolus (YWHAQ) nucleus (YWHAQ)
protein complex (YWHAQ) cytoplasm (YWHAQ)
Anatomy Link Frequency
plasma 1
YWHAQ (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 3 96.64 Very High Very High Very High
antinociception 2 87.20 High High
Morphine 5 85.04 High High
Enkephalin 2 81.60 Quite High
anesthesia 1 81.60 Quite High
fibrosis 8 80.52 Quite High
Clonidine 1 73.92 Quite High
tail-flick 1 72.56 Quite High
Intracerebroventricular 1 67.36 Quite High
Analgesic 1 64.40 Quite High
Disease Link Frequency Relevance Heat
Disease 68 99.32 Very High Very High Very High
Shock 10 99.12 Very High Very High Very High
Targeted Disruption 31 98.36 Very High Very High Very High
Apoptosis 176 95.84 Very High Very High Very High
Injury 9 93.04 High High
Stress 25 86.48 High High
Spinocerebellar Ataxia Type 2 47 86.16 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 81.64 Quite High
Cirrhosis 8 80.52 Quite High
Muscle Disease 1 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This paper reports the presence of N-glycosylated phosducin-like protein long (PhLP(L)) in all structures of mouse CNS, mainly in synaptic plasma membranes and associated with G beta subunits and 14-3-3 proteins.
14-3-3 Binding (associated) of in plasma
1) Confidence 0.47 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015208 Disease Relevance 0.07 Pain Relevance 0.72
Emamian et al. [7] demonstrated that serine 776 (S776) in ataxin 1 (ATXN1) is essential for its pathogenicity in transgenic mice; Chen et al. [8] showed that phosphorylation of this residue by Akt enables 14-3-3 to interact with and stabilize ATXN1.
14-3-3 Binding (interact) of associated with targeted disruption
2) Confidence 0.36 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 1.02 Pain Relevance 0.08
The ablation of K18 S33 phosphorylation site, which regulates the binding to 14-3-3 proteins, caused limited mitotic arrest and accumulation of abnormal mitotic figures after partial hepatectomy (Ku et al. 2002a).
14-3-3 Binding (binding) of
3) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.94 Pain Relevance 0.07
These ligands include natural toxins, such as kabiramide C bound at the actin–gelsolin interface (Fig. 3C) and fusicoccin bound at the interface of 14-3-3 proteins (Fig. 4B).
14-3-3 Binding (bound) of
4) Confidence 0.35 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816688 Disease Relevance 0.08 Pain Relevance 0
It is known, indeed, that 14-3-3 protein contains PPRE recognized and bound by PPAR???
14-3-3 protein Binding (bound) of
5) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.75 Pain Relevance 0
One set are proteins that are associated with Alzheimer’s disease, including myelin basic protein, 14-3-3 protein, syntaxin binding protein munc18, transketolase, heat shock protein HSP70, reelin, and calcium/calmodulin kinase II (Table 1).
14-3-3 protein Binding (syntaxin binding protein munc18) of associated with shock and disease
6) Confidence 0.03 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.63 Pain Relevance 0

General Comments

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