INT102845

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Context Info
Confidence 0.81
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.81
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
macrophage 1
microglia 1
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 97.60 Very High Very High Very High
opiate 3 96.04 Very High Very High Very High
narcan 1 93.20 High High
Inflammation 45 75.00 Quite High
Inflammatory mediators 2 74.76 Quite High
cytokine 17 5.00 Very Low Very Low Very Low
Crohn's disease 7 5.00 Very Low Very Low Very Low
diclofenac 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 116 99.32 Very High Very High Very High
Communicable Diseases 1 98.40 Very High Very High Very High
Disease 104 97.88 Very High Very High Very High
Toxicity 3 95.40 Very High Very High Very High
Neurologic Manifestations 9 93.36 High High
Disease Progression 1 82.48 Quite High
Death 36 81.20 Quite High
Recurrence 13 78.24 Quite High
INFLAMMATION 45 75.00 Quite High
Pyelonephritis 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potent inhibition (>70%) of apoptosis by an inhibitor of caspase-3 as well as co-localization of active caspase-3 and DNA fragmentation in microglia or neurons treated with morphine indicated that caspase-3 is involved in the execution phase of morphine-induced apoptosis.
Localization (co-localization) of caspase-3 in microglia associated with apoptosis and morphine
1) Confidence 0.81 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015209 Disease Relevance 0.96 Pain Relevance 0.98
The antibodies against caspase3, caspase8, caspase9, DR5, Bcl-2, Bax and ?
Localization (caspase9) of caspase3
2) Confidence 0.37 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0 Pain Relevance 0
Cell viability, reactive oxygen species (ROS) and glutathione (GSH) levels, 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) release, p53 phosphorylation, caspase-3, -8, -9 activation, and interleukin (IL)-6 and -8 production were assessed to evaluate and to compare UVB-induced toxicity between cells treated with HMW-HA and cells treated with PBS.


Localization (release) of caspase-3 associated with toxicity
3) Confidence 0.25 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660376 Disease Relevance 0.25 Pain Relevance 0.04
Immunohistochemical staining was performed as previously described [38] using antibodies against TERT (1:350; Calbiochem, San Diego CA), pAkt (1:350; Santa Cruz, Santa Cruz, CA), cleaved caspase-3 (1:20; Oncogene, San Diego CA), ILK (1:200; Stressgen, San Diego CA), ?
Localization (1:350) of caspase-3
4) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0 Pain Relevance 0
Immunohistochemical staining was performed as previously described [38] using antibodies against TERT (1:350; Calbiochem, San Diego CA), pAkt (1:350; Santa Cruz, Santa Cruz, CA), cleaved caspase-3 (1:20; Oncogene, San Diego CA), ILK (1:200; Stressgen, San Diego CA), ?
Localization (cleaved) of caspase-3
5) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0 Pain Relevance 0
A negative correlation was detected between caspase-3 activity and ex vivo release of TNF?
Localization (release) of caspase-3
6) Confidence 0.06 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1397846 Disease Relevance 0.08 Pain Relevance 0
Negative correlation was detected between cytoplasmic caspase-3 and ex vivo secretion of TNF?
Localization (secretion) of cytoplasmic caspase-3
7) Confidence 0.05 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1397846 Disease Relevance 0.55 Pain Relevance 0.04
Whipple's disease (WD) is an infectious disease caused by Tropheryma whipplei, which replicates in macrophages and induces the release of interleukin (IL)-16, a substrate of caspase 3, and macrophage apoptosis.
Localization (release) of caspase 3 in macrophage associated with communicable diseases, apoptosis and disease
8) Confidence 0.02 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1876813 Disease Relevance 0.98 Pain Relevance 0

General Comments

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