INT102848

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
lung 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
Inflammation 6 99.84 Very High Very High Very High
cytokine 2 99.04 Very High Very High Very High
Neurotransmitter 4 94.96 High High
fibrosis 4 75.00 Quite High
Chronic pancreatitis 1 75.00 Quite High
cINOD 1 75.00 Quite High
Spinal cord 1 14.80 Low Low
medulla 15 14.00 Low Low
Hippocampus 2 9.12 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 6 99.90 Very High Very High Very High
INFLAMMATION 7 99.84 Very High Very High Very High
Lung Injury 1 99.20 Very High Very High Very High
Airway Remodeling 1 96.48 Very High Very High Very High
Pulmonary Disease 2 90.24 High High
Asthma 1 88.52 High High
Disease 3 84.80 Quite High
Fibrosis 4 75.00 Quite High
Targeted Disruption 8 71.04 Quite High
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin (IL)-10, a potent anti-inflammatory cytokine, limits the severity of acute pancreatitis and downregulates transforming growth factor (TGF)-beta release by inflammatory cells on stimulation.
Negative_regulation (downregulates) of Localization (release) of TGF associated with inflammation, pancreatitis and cytokine
1) Confidence 0.10 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12016137 Disease Relevance 0.80 Pain Relevance 0.30
Moreover, the analysis of miniature events and hypertonic sucrose stimulation pointed to a presynaptically localized defect in TGF-?
Negative_regulation (defect) of Localization (localized) of TGF
2) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.05
We demonstrated that selective PDE4 inhibitor RP 73-401 reduced matrix metalloproteinase (MMP)-9 activity and TGF-beta1 release during LPS-induced lung injury in mice and that CI-1044 inhibited the production of MMP-1 and MMP-2 from human lung fibroblasts stimulated by pro-inflammatory cytokines.
Negative_regulation (reduced) of Localization (release) of TGF-beta1 in lung associated with lung injury, inflammation, metalloproteinase and cytokine
3) Confidence 0.01 Published 2005 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 15962112 Disease Relevance 1.01 Pain Relevance 0.48

General Comments

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