INT10285

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Context Info
Confidence 0.47
First Reported 1980
Last Reported 2007
Negated 5
Speculated 4
Reported most in Abstract
Documents 102
Total Number 106
Disease Relevance 25.82
Pain Relevance 31.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
plasma 20
blood 3
aorta 1
erythrocytes 1
medulla 1
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 111 100.00 Very High Very High Very High
Clonidine 53 100.00 Very High Very High Very High
methadone 49 100.00 Very High Very High Very High
rapifen 19 100.00 Very High Very High Very High
local anesthetic 13 100.00 Very High Very High Very High
medulla 12 100.00 Very High Very High Very High
Codeine 12 99.98 Very High Very High Very High
agonist 28 99.96 Very High Very High Very High
Pain 8 99.78 Very High Very High Very High
carbamazepine 6 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 44 100.00 Very High Very High Very High
Cancer 11 100.00 Very High Very High Very High
Toxocariasis 8 100.00 Very High Very High Very High
Urological Neuroanatomy 4 100.00 Very High Very High Very High
Injury 32 99.84 Very High Very High Very High
Rheumatic Diseases 4 99.84 Very High Very High Very High
Alzheimer's Dementia 5 99.78 Very High Very High Very High
Hypotension 3 99.56 Very High Very High Very High
Disease 19 99.28 Very High Very High Very High
Low Back Pain 8 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
alpha 1-Acid glycoprotein and plasma lidocaine binding.
alpha 1 Binding (binding) of in plasma associated with lidocaine
1) Confidence 0.47 Published 1984 Journal Clin Pharmacokinet Section Title Doc Link 6705424 Disease Relevance 0.35 Pain Relevance 0.43
Methodologic factors influencing plasma binding of alpha-1-acid glycoprotein-bound and albumin-bound drugs.
alpha-1 Binding (binding) of in plasma
2) Confidence 0.47 Published 1985 Journal Int J Clin Pharmacol Ther Toxicol Section Title Doc Link 3934087 Disease Relevance 0 Pain Relevance 0.41
In addition to changing serum drug concentration/response relationships, the pharmacokinetic behavior of drugs bound to alpha 1-acid glycoprotein should also change.
alpha 1 Binding (bound) of
3) Confidence 0.47 Published 1985 Journal Drug Intell Clin Pharm Section Abstract Doc Link 3905320 Disease Relevance 0.40 Pain Relevance 0.30
Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors.
alpha1 Binding (binding) of associated with anesthesia and antagonist
4) Confidence 0.47 Published 1999 Journal Jpn. J. Pharmacol. Section Title Doc Link 10361884 Disease Relevance 0 Pain Relevance 0.29
The majority of drug binding to macromolecules in serum can be accounted for by association with albumin and alpha 1-acid glycoprotein.
alpha 1 Binding (association) of
5) Confidence 0.47 Published 1986 Journal Clin Pharmacokinet Section Abstract Doc Link 3542337 Disease Relevance 0.75 Pain Relevance 0.10
In contrast, some studies report that drugs bound to alpha 1-acid glycoprotein (AAG) may have increased binding that is related to increased serum AAG concentration; however, this is not a consistent finding.
alpha 1 Binding (bound) of
6) Confidence 0.47 Published 1986 Journal Clin Pharmacokinet Section Abstract Doc Link 3524955 Disease Relevance 0.77 Pain Relevance 0.20
The effect of in vitro treatment of serum with the alkylating agents carmustine (BCNU) and mechlorethamine on the protein binding of penbutolol, a basic agent mainly bound to alpha 1-acid glycoprotein (AAG), was investigated.
alpha 1 Binding (bound) of
7) Confidence 0.47 Published 1994 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 8174208 Disease Relevance 0 Pain Relevance 0
Buspirone is mainly bound to albumin and alpha 1-acid glycoprotein.
alpha 1 Binding (bound) of
8) Confidence 0.47 Published 1988 Journal Pharmacotherapy Section Abstract Doc Link 3041384 Disease Relevance 0.69 Pain Relevance 0.37
A series of 4-amino-6-chloro-2-piperazinopyrimidines were synthesized and evaluated for their ability to interact with alpha 1- and alpha 2-adrenoceptors in vitro in binding assays using [3H]WB-4101, [3H]clonidine, and [3H]idazoxan as radioligands.
alpha 1 Binding (interact) of associated with clonidine
9) Confidence 0.47 Published 1986 Journal J. Med. Chem. Section Abstract Doc Link 3016265 Disease Relevance 0 Pain Relevance 0.13
Comparative studies on the antihypertensive potency of selective alpha 2 agonists like rilmenidine, guanfacine, clonidine and lofexidine suggest that the relative ability to bind to alpha 1 and alpha 2 adrenoceptors is not critical but the ability to enter the central nervous system is essential for antihypertensive efficacy.
alpha 1 Binding (bind) of in central nervous system associated with agonist, central nervous system, clonidine and potency
10) Confidence 0.47 Published 1988 Journal Am. J. Cardiol. Section Abstract Doc Link 2894151 Disease Relevance 0 Pain Relevance 0.40
Peptoid trimer CHIR 2279 binds to the alpha 1-adrenergic receptor with a Ki of 5 nM, and trimer CHIR 4531 binds to the mu-opiate receptor with a Ki of 6 nM.
alpha 1 Binding (binds) of associated with opiate
11) Confidence 0.47 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8064796 Disease Relevance 0 Pain Relevance 0.10
A cationic fluorescent dye, auramine O (AO), exhibited an intense increase in fluorescence after binding to human alpha 1-acid glycoprotein (alpha 1-AG).
alpha 1 Binding (binding) of
12) Confidence 0.47 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3977957 Disease Relevance 0 Pain Relevance 0.12
The tetrahydroprotoberberines, as a class, were the most potent inhibitors of 3H-spiroperidol binding to dopaminergic receptor antagonist sites and of 3H-WB-4101 binding to alpha 1-adrenergic receptors.
alpha 1 Binding (binding) of associated with antagonist
13) Confidence 0.47 Published 1983 Journal J. Neurosci. Res. Section Abstract Doc Link 6313954 Disease Relevance 0 Pain Relevance 0.30
Imipramine binding to alpha-1-acid glycoprotein in normal subjects and cardiac patients.
alpha-1 Binding (binding) of associated with pain
14) Confidence 0.47 Published 1984 Journal Clin. Pharmacol. Ther. Section Title Doc Link 6713778 Disease Relevance 0.33 Pain Relevance 0.27
Tris (2-butoxyethyl) phosphate (TBEP) is a plasticizer used in the rubber stoppers of evacuated blood collection tubes which disrupts the binding of basic drugs to the carrier protein alpha-1-acid glycoprotein (AAG).
alpha-1 Binding (binding) of in blood
15) Confidence 0.47 Published 1984 Journal Clin. Biochem. Section Abstract Doc Link 6518648 Disease Relevance 0 Pain Relevance 0.13
A number of drugs bind to alpha 1-acid glycoprotein in plasma.
alpha 1 Binding (bind) of in plasma
16) Confidence 0.47 Published 1981 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7471620 Disease Relevance 0 Pain Relevance 0.13
The free fraction of a drug in plasma can be increased (when primarily bound to albumin) or decreased (when primarily bound to alpha 1-acid glycoprotein).
alpha 1 Binding (bound) of in plasma
17) Confidence 0.47 Published 1995 Journal Clin Pharmacokinet Section Abstract Doc Link 7586895 Disease Relevance 0.70 Pain Relevance 0.14
The acute phase reactant, alpha-1-acid glycoprotein, binds to a number of basic antiarrhythmic drugs, including lidocaine, quinidine, propranolol, imipramine and disopyramide.
alpha-1 Binding (binds) of associated with lidocaine
18) Confidence 0.47 Published 1985 Journal Am. J. Cardiol. Section Abstract Doc Link 4025163 Disease Relevance 0.41 Pain Relevance 0.15
Auramine O as a fluorescent probe for the binding of basic drugs to human alpha 1-acid glycoprotein (alpha 1-AG).
alpha 1 Binding (binding) of
19) Confidence 0.47 Published 1985 Journal Biochem. Pharmacol. Section Title Doc Link 3977957 Disease Relevance 0 Pain Relevance 0.12
Auramine O as a fluorescent probe for the binding of basic drugs to human alpha 1-acid glycoprotein (alpha 1-AG).
alpha 1 Binding (binding) of
20) Confidence 0.47 Published 1985 Journal Biochem. Pharmacol. Section Title Doc Link 3977957 Disease Relevance 0 Pain Relevance 0.12

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