INT102850

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.06
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
dorsal root ganglion 2
sensory neurons 1
nerve 1
pore 1
Trpv3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 161 99.98 Very High Very High Very High
qutenza 184 99.84 Very High Very High Very High
imagery 45 97.20 Very High Very High Very High
Potency 37 96.70 Very High Very High Very High
TRP channel 246 94.48 High High
Pain 43 92.72 High High
agonist 123 92.36 High High
alcohol 42 89.08 High High
dorsal root ganglion 28 79.68 Quite High
pruritus 2 79.36 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 198 99.82 Very High Very High Very High
Pain 45 92.72 High High
Myelodysplastic Syndromes 1 89.80 High High
Pruritus 18 79.36 Quite High
Neurogenic Inflammation 3 75.00 Quite High
Dermatitis 1 65.52 Quite High
Congenital Anomalies 2 61.44 Quite High
Nociception 7 57.28 Quite High
Loss Of Sense Of Smell 14 55.68 Quite High
Neuropathic Pain 39 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.
Gene_expression (expressed) of TRPV3 in neurons
1) Confidence 0.56 Published 2002 Journal Science Section Abstract Doc Link 12016205 Disease Relevance 0 Pain Relevance 0.08
Based on in situ hybridization data [17], our laboratory reported that TRPV3 was ubiquitously expressed in dorsal root ganglion neurons.
Gene_expression (expressed) of TRPV3 in dorsal root ganglion associated with ganglion cysts and root ganglion neuron
2) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.31 Pain Relevance 0.43
Using citral and 2-aminoethyldiphenyl borate as pharmacological tools, we found that the majority of cells from juvenile rat dorsal root ganglion neurons expressed functional TRPV1, TRPV2, and TRPV3 channels.
Gene_expression (expressed) of TRPV3 in dorsal root ganglion associated with ganglion cysts and root ganglion neuron
3) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.41 Pain Relevance 0.24
We find that TRPV2 and TRPV3 channels are present in a high proportion of these neurons (94% respond to 2-aminoethyldiphenyl borate), consistent with our immunolabeling experiments and previous in situ hybridization studies.
Gene_expression (channels) of TRPV3 in neurons
4) Confidence 0.44 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2346451 Disease Relevance 0.28 Pain Relevance 0.43
Citral's primary potency on TRPM8 may explain its initial ‘cool’ sensation, and citral may modulate a plethora of skin, nerve, and epithelial cell-mediated sensory responses via the TRPV2, TRPV3, TRPV4, and TRPA1 channels.
Gene_expression (channels) of TRPV3 in epithelial cell associated with potency
5) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.60
The remaining TRPV2 or TRPV3 channels could then be separated.
Gene_expression (channels) of TRPV3
6) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.13 Pain Relevance 0.20
For example, upon expressing TRPV3 in cultured cells, Grandl et al. (2008) used high throughput calcium imaging to screen for TRPV3 mutants that abolish heat activation but retain activation by camphor or 2-aminoethoxydiphenyl borate.
Gene_expression (expressing) of TRPV3 associated with imagery
7) Confidence 0.37 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571970 Disease Relevance 0 Pain Relevance 0.05
Previous reports demonstrated that HC-030031 does not block TRPV1, TRPV3 or TRPV4 activation by capsaicin, 2-APB, and 4?
Gene_expression (activation) of TRPV3 associated with qutenza
8) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.23 Pain Relevance 0.28
Interestingly, the constitutive pore helix mutations recovered from the TRPV1 yeast screen were found to produce similar effects when introduced into TRPV2 and TRPV3, supporting the notion that this region of TRPV channels forms a conserved part of the gating machinery (Myers et al., 2008).
Gene_expression (introduced) of TRPV3 in pore
9) Confidence 0.32 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571970 Disease Relevance 0.06 Pain Relevance 0.03
The temperature-sensitive transient receptor potential (TRP) channels, is also called thermo TRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal cells (e.g.keratinocyte, mast cell) of the skin.
Gene_expression (expressed) of TRPV3 in sensory neurons
10) Confidence 0.19 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 19693981 Disease Relevance 0.63 Pain Relevance 0.47
Citral's primary potency on TRPM8 may explain its initial ‘cool’ sensation, and citral may modulate a plethora of skin, nerve, and epithelial cell-mediated sensory responses via the TRPV2, TRPV3, TRPV4, and TRPA1 channels.
Gene_expression (channels) of TRPV3 in nerve associated with potency
11) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.60
Citral's primary potency on TRPM8 may explain its initial ‘cool’ sensation, and citral may modulate a plethora of skin, nerve, and epithelial cell-mediated sensory responses via the TRPV2, TRPV3, TRPV4, and TRPA1 channels.
Gene_expression (channels) of TRPV3 in skin associated with potency
12) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.60

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