INT102856

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.27
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Srgn) extracellular region (Srgn) Golgi apparatus (Srgn)
Anatomy Link Frequency
cardiomyocytes 1
small intestine 1
hippocampus 1
cerebellum 1
Srgn (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 9 99.90 Very High Very High Very High
Neurotransmitter 6 99.88 Very High Very High Very High
potassium channel 1 99.84 Very High Very High Very High
tetrodotoxin 3 97.90 Very High Very High Very High
Hippocampus 7 96.16 Very High Very High Very High
Pain 22 95.12 Very High Very High Very High
cytokine 8 93.96 High High
Inflammation 52 93.56 High High
antagonist 9 93.00 High High
narcan 2 86.60 High High
Disease Link Frequency Relevance Heat
Pain 30 95.12 Very High Very High Very High
INFLAMMATION 62 93.56 High High
Stomach Cancer 1 84.72 Quite High
Morphine Dependence 2 83.00 Quite High
Nociception 12 82.28 Quite High
Erectile Dysfunction 1 73.48 Quite High
Neuroblastoma 1 65.92 Quite High
Injury 18 52.72 Quite High
Disease 38 42.64 Quite Low
Drug Induced Neurotoxicity 10 42.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the striatum and cerebral cortex the sGC activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (3) The PDE activities showed no change in cerebellum and hippocampus, but in striatum and cerebral cortex PDE activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Positive_regulation (increased) of sGC in hippocampus associated with narcan, hippocampus, cerebral cortex and morphine
1) Confidence 0.61 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.08 Pain Relevance 0.66
The relaxant effect of F(3-5) (100 microg ml(-1)) on phenylephrine contraction was unaffected in the presence of atropine, N-omega-nitro-L-arginine methyl ester or 1H-[1,2,4]oxadiazole[4,3-a] quinoxalin-1-one and by preincubation with tetrodotoxin, glibenclamide, apamine and charybdotoxin suggesting that mechanisms other than cholinergic, nitrergic, sGC activation or potassium channel opening are probably involved.
Positive_regulation (activation) of sGC associated with tetrodotoxin and potassium channel
2) Confidence 0.47 Published 2008 Journal Int. J. Impot. Res. Section Abstract Doc Link 18046335 Disease Relevance 0.07 Pain Relevance 0.15
It should be recalled, that NO signaling plays an important role in the functioning of the CNS, and activation of soluble guanylate cuclase (sGC) represent one important effect of NO.
Positive_regulation (activation) of sGC
3) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.60 Pain Relevance 0.48
In the striatum and cerebral cortex the sGC activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (3) The PDE activities showed no change in cerebellum and hippocampus, but in striatum and cerebral cortex PDE activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Positive_regulation (increased) of sGC in cerebellum associated with narcan, hippocampus, cerebral cortex and morphine
4) Confidence 0.21 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.08 Pain Relevance 0.66
Our previous55 report provided the evidence that ESC-derived cardiomyocytes express a functional sGC enzyme that can be activated upon NO stimulation to produce cGMP.
Neg (NO) Positive_regulation (activated) of sGC in cardiomyocytes
5) Confidence 0.12 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.08 Pain Relevance 0
In the first pathway, NO stimulates soluble guanylyl cyclase (sGC) to increase cyclic guanosine monophosphate (cGMP), which in turn modulates a variety of downstream signaling targets [4].
Positive_regulation (stimulates) of sGC
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0.34 Pain Relevance 0.18
NO from motor nerves is a potent inhibitory neurotransmitter that activates soluble guanylate cyclase (sGC) in the target cells. sGC is expressed in ICC-DMP of the rat small intestine [34] and almost all ICC in the guinea pig [20].
Positive_regulation (activates) of sGC in small intestine associated with neurotransmitter
7) Confidence 0.08 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.42

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox