INT102857

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.26
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Srgn) extracellular region (Srgn) Golgi apparatus (Srgn)
Anatomy Link Frequency
hippocampus 1
cerebellum 1
Srgn (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 12 99.90 Very High Very High Very High
addiction 3 98.10 Very High Very High Very High
Morphine 12 97.88 Very High Very High Very High
Hippocampus 9 94.36 High High
narcan 3 84.80 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 3 98.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By inducing morphine dependence in mice, the changes of cGMP contents, phosphodiesterase (PDE) and soluble guanylate cyclase (sGC) activities and their phosphorylation regulated by protein kinase A (PKA) were observed.
Phosphorylation (phosphorylation) of sGC associated with addiction and morphine
1) Confidence 0.72 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.10 Pain Relevance 0.41
In the striatum and cerebral cortex the sGC activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (3) The PDE activities showed no change in cerebellum and hippocampus, but in striatum and cerebral cortex PDE activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Phosphorylation (phosphorylation) of sGC in hippocampus associated with narcan, hippocampus, cerebral cortex and morphine
2) Confidence 0.72 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.08 Pain Relevance 0.65
In the striatum and cerebral cortex the sGC activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (3) The PDE activities showed no change in cerebellum and hippocampus, but in striatum and cerebral cortex PDE activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Phosphorylation (phosphorylation) of sGC in cerebellum associated with narcan, hippocampus, cerebral cortex and morphine
3) Confidence 0.25 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.08 Pain Relevance 0.65

General Comments

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