INT10286

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 4.05
Pain Relevance 18.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
duodenum 5
spinal cord 4
pylorus 4
sensory neurons 2
plasma 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 187 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
Deafferentation 2 99.98 Very High Very High Very High
Morphine 49 99.80 Very High Very High Very High
Glutamate 5 99.80 Very High Very High Very High
primary afferent fibers 3 99.44 Very High Very High Very High
substance P 12 99.36 Very High Very High Very High
Dorsal horn 20 99.20 Very High Very High Very High
Pain 11 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 5 99.98 Very High Very High Very High
Nervous System Injury 2 99.98 Very High Very High Very High
Exocrine Pancreatic Insufficiency 2 99.28 Very High Very High Very High
Pain 8 99.10 Very High Very High Very High
Functional Bowel Disorder 2 98.48 Very High Very High Very High
Pancreatitis 10 98.12 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 97.44 Very High Very High Very High
Nociception 1 94.16 High High
Lordosis 3 93.40 High High
Hyperalgesia 4 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K+ (100 mM) in the perfusion medium induced a more than 3-fold increase of the extracellular level of CCK-LI in control animals, and a more than 4-fold increase on CCK-LI in morphine-pellet implanted animals.
Positive_regulation (induced) of Positive_regulation (increase) of CCK associated with morphine
1) Confidence 0.70 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064790 Disease Relevance 0 Pain Relevance 1.54
K+ (100 mM) in the perfusion medium induced a more than 3-fold increase of the extracellular level of CCK-LI in control animals, and a more than 4-fold increase on CCK-LI in morphine-pellet implanted animals.
Positive_regulation (induced) of Positive_regulation (increase) of CCK associated with morphine
2) Confidence 0.70 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064790 Disease Relevance 0 Pain Relevance 1.56
Increases of CCK mRNA and peptide in different brain areas following acute and chronic administration of morphine.
Positive_regulation (following) of Positive_regulation (Increases) of CCK in brain associated with analgesic and morphine
3) Confidence 0.50 Published 1993 Journal Brain Res. Section Title Doc Link 8242392 Disease Relevance 0.08 Pain Relevance 0.97
The actions of cholecystokinin (CCK) in the production of a satiety-like state have been suggested to be mediated via receptors for CCK which are located in the pylorus.
Positive_regulation (mediated) of Positive_regulation (actions) of cholecystokinin in pylorus associated with cholecystokinin
4) Confidence 0.50 Published 1987 Journal Peptides Section Abstract Doc Link 3033618 Disease Relevance 0 Pain Relevance 0.34
The actions of cholecystokinin (CCK) in the production of a satiety-like state have been suggested to be mediated via receptors for CCK which are located in the pylorus.
Positive_regulation (mediated) of Positive_regulation (actions) of CCK in pylorus associated with cholecystokinin
5) Confidence 0.50 Published 1987 Journal Peptides Section Abstract Doc Link 3033618 Disease Relevance 0 Pain Relevance 0.34
The estrogenic induction of CCK mRNA appears to be dependent on estrogen sensitive pathways of neurotransmission, or components of second messenger pathways which regulate CCK mRNA expression in the adult limbic-hypothalamic lordosis regulating circuit, which are not functional before PND 18-25.
Spec (appears) Positive_regulation (dependent) of Positive_regulation (induction) of CCK mRNA associated with lordosis and cholecystokinin
6) Confidence 0.50 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9482232 Disease Relevance 0.15 Pain Relevance 0.44
Nerve injury induces upregulation of CCK mRNA and CCK2 receptors in sensory neurons.
Positive_regulation (induces) of Positive_regulation (upregulation) of CCK mRNA in sensory neurons associated with nervous system injury and cholecystokinin
7) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10612699 Disease Relevance 0.25 Pain Relevance 1.05
These data suggest that 1) most MDH CCK is of non-primary afferent origin, 2) gastrin immunoreactivity in layer II probably originates in CCK-containing cells intrinsic to layer II, the expression of which is dependent upon trigeminal primary afferent input, 3) neonatal V deafferentation induces increased CCK in the superficial MDH, reflecting reorganized intrinsic or higher-order inputs, and 4) higher-order substance P in the MDH is robust.
Positive_regulation (induces) of Positive_regulation (increased) of CCK in MDH associated with dorsal horn, cholecystokinin, substance p and deafferentation
8) Confidence 0.50 Published 1992 Journal J. Comp. Neurol. Section Abstract Doc Link 1479068 Disease Relevance 0 Pain Relevance 0.86
To demonstrate that endogenously released CCK also acts on high-affinity CCK-A receptors, we showed that in conscious rats intraduodenal infusion of 18% casein produced a threefold increase in protein secretion and elevated plasma CCK levels from 0.7 to 8.4 pM.
Positive_regulation (increase) of Positive_regulation (increase) of CCK in plasma associated with cholecystokinin
9) Confidence 0.50 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9316472 Disease Relevance 0 Pain Relevance 1.21
Cholecystokinin (CCK) response to a test meal should be increased in patients with pancreatic insufficiency, as trypsin is absent from the duodenum.
Positive_regulation (increased) of Positive_regulation (increased) of Cholecystokinin in duodenum associated with exocrine pancreatic insufficiency and cholecystokinin
10) Confidence 0.49 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539652 Disease Relevance 0.34 Pain Relevance 0.44
Cholecystokinin (CCK) response to a test meal should be increased in patients with pancreatic insufficiency, as trypsin is absent from the duodenum.
Positive_regulation (increased) of Positive_regulation (increased) of CCK in duodenum associated with exocrine pancreatic insufficiency and cholecystokinin
11) Confidence 0.49 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539652 Disease Relevance 0.34 Pain Relevance 0.44
Intraduodenal infusion of Clinimeal did not result in a significant physiological rise of CCK and PP from the basal values.
Neg (not) Positive_regulation (result) of Positive_regulation (rise) of CCK associated with cholecystokinin
12) Confidence 0.47 Published 1989 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 2585797 Disease Relevance 0.66 Pain Relevance 0.63
Recent experimental evidence indicates that negative verbal suggestions induce anticipatory anxiety about the impending pain increase, and this verbally-induced anxiety triggers the activation of cholecystokinin (CCK) which, in turn, facilitates pain transmission.
Positive_regulation (triggers) of Positive_regulation (activation) of CCK associated with pain, anxiety disorder and cholecystokinin
13) Confidence 0.47 Published 2007 Journal Neuroscience Section Abstract Doc Link 17379417 Disease Relevance 0.98 Pain Relevance 0.73
Although the other three peptides remained unaffected all along the cord by either intervention, evidence for the existence of capsaicin-insensitive CCKergic primary afferent fibers could be inferred from the increased accumulation of CCK (together with SP and CGRP) in dorsal root ganglia ipsilateral to dorsal root sections.
Positive_regulation (increased) of Positive_regulation (accumulation) of CCK in dorsal root ganglia associated with qutenza, primary afferent fibers, cholecystokinin, calcitonin gene-related peptide and substance p
14) Confidence 0.46 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1697886 Disease Relevance 0 Pain Relevance 1.61
As a result, postprandial biliary and pancreatic secretion will be reduced or eliminated, and the negative feedback effect of the bile acid and pancreatic juice on cholecystokinin (CCK)-producing cells in the duodenum and jejunum will be deprived, thereby leading to an increase in circulating CCK levels.
Positive_regulation (leading) of Positive_regulation (increase) of CCK in bile associated with bile and cholecystokinin
15) Confidence 0.45 Published 2010 Journal J Gastrointest Surg Section Body Doc Link PMC2943575 Disease Relevance 0.46 Pain Relevance 0.31
It has been shown that the subject's negative expectations of pain worsening induce anticipatory anxiety about the impending pain increase and this triggers the activation of cholecystokinin that, in turn, facilitates pain transmission.
Positive_regulation (triggers) of Positive_regulation (activation) of cholecystokinin
16) Confidence 0.45 Published 2007 Journal Curr Opin Anaesthesiol Section Body Doc Link 17873596 Disease Relevance 0.09 Pain Relevance 0
Activation of neural cholecystokinin-1 receptors induces relaxation of the isolated rat duodenum which is reduced by nitric oxide synthase inhibitors.
Positive_regulation (induces) of in duodenum Positive_regulation (Activation) of cholecystokinin in neural associated with cholecystokinin
17) Confidence 0.44 Published 2006 Journal Braz. J. Med. Biol. Res. Section Title Doc Link 16470315 Disease Relevance 0 Pain Relevance 0.58
The results are also consistent with a mechanism in which the level of activation of compensatory, anti-opioid CCK circuitry is increased in proportion to the functional level of opioid pathways.
Positive_regulation (increased) of Positive_regulation (activation) of CCK associated with cholecystokinin and opioid
18) Confidence 0.41 Published 1991 Journal Pain Section Abstract Doc Link 1762818 Disease Relevance 0 Pain Relevance 1.71
Conflicting results concerning the issue of whether or not chronic morphine exposure induces an increase in CCK biosynthesis have been found in many CNS sites, including the spinal cord, where CCK activity may contribute to the facilitation of the development of opiate tolerance.
Spec (whether) Positive_regulation (induces) of Spec (whether) Positive_regulation (increase) of CCK in spinal cord associated with tolerance, opiate, spinal cord and morphine
19) Confidence 0.41 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064790 Disease Relevance 0 Pain Relevance 0.88
Transection of the upper cervical cord resulted in accumulations of cholecystokinin-8 and glutamate decarboxylase rostral to the lesion, revealing the presence of supraspinal projections of cholecystokinin-8 and glutamate decarboxylase to the spinal cord.
Positive_regulation (resulted) of Positive_regulation (accumulations) of cholecystokinin-8 in spinal cord associated with glutamate, cholecystokinin and spinal cord
20) Confidence 0.40 Published 1985 Journal Neuroscience Section Abstract Doc Link 3887208 Disease Relevance 0.07 Pain Relevance 0.69

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