INT102861

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.86
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
hippocampus 1
cerebellum 1
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 12 99.98 Very High Very High Very High
Hippocampus 9 99.24 Very High Very High Very High
addiction 3 98.82 Very High Very High Very High
Morphine 13 98.60 Very High Very High Very High
narcan 3 93.76 High High
Inflammation 38 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cryotherapy 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Keratosis 23 99.84 Very High Very High Very High
Morphine Dependence 3 98.82 Very High Very High Very High
Hypoxia 3 86.44 High High
Cancer 48 68.32 Quite High
Hepatocellular Cancer 20 50.00 Quite Low
Skin Cancer 56 5.00 Very Low Very Low Very Low
INFLAMMATION 44 5.00 Very Low Very Low Very Low
Pulmonary Disease 31 5.00 Very Low Very Low Very Low
Apoptosis 31 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both ALA and MAL have been applied as photosensitizisers for PDT of AK.
Phosphorylation (photosensitizisers) of PDT associated with keratosis
1) Confidence 0.70 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503644 Disease Relevance 0.36 Pain Relevance 0
In vivo study of Pa-PDT on R-HepG2 cells bearing nude mice
Phosphorylation (study) of Pa-PDT
2) Confidence 0.58 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.25 Pain Relevance 0
By inducing morphine dependence in mice, the changes of cGMP contents, phosphodiesterase (PDE) and soluble guanylate cyclase (sGC) activities and their phosphorylation regulated by protein kinase A (PKA) were observed.
Phosphorylation (phosphorylation) of PDE associated with addiction and morphine
3) Confidence 0.47 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.10 Pain Relevance 0.41
In the striatum and cerebral cortex the sGC activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (3) The PDE activities showed no change in cerebellum and hippocampus, but in striatum and cerebral cortex PDE activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Phosphorylation (phosphorylation) of PDE in hippocampus associated with narcan, hippocampus, cerebral cortex and morphine
4) Confidence 0.47 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.07 Pain Relevance 0.70
In the striatum and cerebral cortex the sGC activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (3) The PDE activities showed no change in cerebellum and hippocampus, but in striatum and cerebral cortex PDE activities and phosphorylation levels in vitro were significantly increased and were inhibited by PKA inhibitor. (4) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection.
Phosphorylation (phosphorylation) of PDE in cerebellum associated with narcan, hippocampus, cerebral cortex and morphine
5) Confidence 0.16 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016853 Disease Relevance 0.07 Pain Relevance 0.70
There are domains that are essential for ligand binding, PDE oligomerization domains and kinase recognition and phosphorylation domains which regulate PDE function.
Phosphorylation (phosphorylation) of PDE
6) Confidence 0.03 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0

General Comments

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