INT102865

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 29
Disease Relevance 8.34
Pain Relevance 9.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
respiratory 6
paw 4
livers 2
spinal cord 2
brain 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 362 100.00 Very High Very High Very High
Hyperalgesia 40 100.00 Very High Very High Very High
Spinal cord 16 100.00 Very High Very High Very High
nociceptor 155 99.98 Very High Very High Very High
addiction 38 99.36 Very High Very High Very High
allodynia 11 99.24 Very High Very High Very High
imagery 22 98.96 Very High Very High Very High
Pain 123 98.56 Very High Very High Very High
amygdala 104 98.56 Very High Very High Very High
diabetic neuropathy 5 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 68 100.00 Very High Very High Very High
Hyperalgesia 52 100.00 Very High Very High Very High
Insulin Resistance 21 100.00 Very High Very High Very High
Nociception 81 99.98 Very High Very High Very High
Neuropathic Pain 27 99.24 Very High Very High Very High
Poisoning 1 98.92 Very High Very High Very High
Diabetes Mellitus 111 98.64 Very High Very High Very High
Pain 121 98.56 Very High Very High Very High
Diabetic Neuropathy 5 97.72 Very High Very High Very High
Glioma 1 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that the increase of inositol phosphate contents in striatum implied activation of phospholipase C, which might lead to PKC activation.
Spec (might) Positive_regulation (lead) of Spec (might) Positive_regulation (activation) of PKC in striatum
1) Confidence 0.69 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.21 Pain Relevance 0.90
Collectively, the results of the present study have shown that PMA injection into the mouse paw results in PKC activation as well as a relatively delayed, but long-lasting, overt nociceptive behaviour in mice.
Positive_regulation (results) of Positive_regulation (activation) of PKC in paw associated with nociception and kinase c
2) Confidence 0.60 Published 2005 Journal Pain Section Abstract Doc Link 16099101 Disease Relevance 0.70 Pain Relevance 0.33
The aim of the present study was to investigate whether direct activation of protein kinase C (PKC) in the spinal cord could change brain activation using a functional magnetic resonance imaging (fMRI) analysis in mice that lack the PKCgamma gene.
Positive_regulation (change) of Positive_regulation (activation) of PKC in brain associated with kinase c, imagery and spinal cord
3) Confidence 0.47 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18242849 Disease Relevance 0.07 Pain Relevance 0.57
These results suggest that activation of Ca(2+)-dependent PKC in the spinal cord, contributes to the mechanical allodynia in the pain associated with diabetic neuropathy.
Positive_regulation (contributes) of Positive_regulation (activation) of PKC in spinal cord associated with pain, kinase c, allodynia, diabetic neuropathy and spinal cord
4) Confidence 0.43 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17473449 Disease Relevance 1.03 Pain Relevance 0.90
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.
Positive_regulation (induces) of Positive_regulation (activation) of PKC associated with hyperalgesia
5) Confidence 0.41 Published 2004 Journal Neuropharmacology Section Title Doc Link 15223308 Disease Relevance 0.65 Pain Relevance 0.85
The peripheral injection of phorbol myristate acetate (PMA) into the mouse paw induces nociception mediated through activation of protein kinase C (PKC).
Positive_regulation (mediated) of Positive_regulation (activation) of PKC in paw associated with nociception and kinase c
6) Confidence 0.39 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18164734 Disease Relevance 0.58 Pain Relevance 0.50
Instead, diacylglycerol induces insulin resistance via activation of PKC?
Positive_regulation (induces) of Positive_regulation (activation) of PKC associated with insulin resistance
7) Confidence 0.27 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 1.05 Pain Relevance 0
Long-term exposure to Pb leads to PKC activation in rat livers; however, Pb also inhibited the activity of PKC?
Positive_regulation (leads) of Positive_regulation (activation) of PKC in livers associated with kinase c
8) Confidence 0.26 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.29 Pain Relevance 0.18
Possible involvement of PKA and PKC pathways in the voltage dependence of inactivation for the NaV1.9 current
Positive_regulation (pathways) of Spec (Possible) Positive_regulation (involvement) of PKC associated with addiction
9) Confidence 0.23 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0.14
The CRF1 receptor is a G-protein-coupled receptor (GPCR) that is predominantly linked to the activation of adenylyl cyclase (AC), and also other second messenger systems such as inositol trisphosphate and protein kinase C (PKC; Grammatopoulos et al., 2001; Blank et al., 2003).
Positive_regulation (linked) of Positive_regulation (activation) of PKC associated with kinase c
10) Confidence 0.19 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.18 Pain Relevance 0.43
Akt induces a rapid and transient phosphorylation of nNOS Ser1417 (7) resulting in increased NO production (8), release of zinc ions from metallothioneins (9) and recruitment of PKC?
Positive_regulation (resulting) of Positive_regulation (recruitment) of PKC associated with kinase c
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.32
CRF1 is a GPCR that is positively linked to the activation of AC and other second messenger systems such as IP3 and PKC (Bajo et al., 2008).
Positive_regulation (linked) of Positive_regulation (activation) of PKC
12) Confidence 0.18 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.39 Pain Relevance 0.35
MAPK and PKC activate each other indirectly through PLA2, arachidonic acid, and Raf (Bhalla et al, 2002), contributing to sustained CaMKII activation through PKC-mediated up-regulation of a type of adenylyl cyclase (Bhalla and Iyengar, 1999).
Positive_regulation (contributing) of Positive_regulation (activation) of PKC-mediated
13) Confidence 0.14 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.04
The increase in intracellular calcium level may serve as an indicator of PLC activation and a cofactor for PKC activation after PMA treatment.
Positive_regulation (cofactor) of Positive_regulation (activation) of PKC associated with kinase c
14) Confidence 0.13 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.07 Pain Relevance 0.32
Our data support the view that PKC activation is necessary for the inhibition of SK channels, but we cannot rule out an additional role for Ca2+ release and/or PIP2 depletion.
Positive_regulation (necessary) of Positive_regulation (activation) of PKC
15) Confidence 0.12 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.08 Pain Relevance 0.13
M1 receptors are thought to couple to Gq/11 subunits whose downstream signaling bifurcates into the production of IP3 and DAG, leading to activation of PKC (Delmas and Brown, 2005).
Positive_regulation (leading) of Positive_regulation (activation) of PKC
16) Confidence 0.12 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.03
To determine whether the PKC activation was sufficient to cause proximal splice site selection, cells were treated with 100 nm phorbol myristate acetate (PMA), which is known to induce PKC activation.
Positive_regulation (induce) of Positive_regulation (activation) of PKC in proximal
17) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Thus it is likely that UTP activation of P2Y2 leads to a Gq-dependent potentiation of the RA current which does not require prior activation of PKC.
Positive_regulation (potentiation) of Positive_regulation (activation) of PKC associated with kinase c and rheumatoid arthritis
18) Confidence 0.11 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.32 Pain Relevance 0.45
3 s) while stimulation of PKC only enhanced mechanosensitive currents after more than 1 h (Di Castro et al. 2006).
Positive_regulation (enhanced) of Positive_regulation (stimulation) of PKC associated with kinase c
19) Confidence 0.11 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.29 Pain Relevance 0.67
In order to determine whether intracellular calcium or PKC activation mediate the observed cross-talk, the cells were incubated with specific IP3R blocker (2-APB; 40 ?
Positive_regulation (mediate) of Spec (whether) Positive_regulation (activation) of PKC associated with kinase c
20) Confidence 0.11 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.25

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