INT102866

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.27
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
spinal 2
brain 2
platelet 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 231 100.00 Very High Very High Very High
Morphine 6 99.08 Very High Very High Very High
Pain 8 98.80 Very High Very High Very High
addiction 13 98.72 Very High Very High Very High
nMDA receptor 2 97.72 Very High Very High Very High
Dorsal horn 1 95.60 Very High Very High Very High
Spinal cord 2 95.12 Very High Very High Very High
intrathecal 3 92.16 High High
agonist 5 88.48 High High
cerebral cortex 3 86.48 High High
Disease Link Frequency Relevance Heat
Adhesions 10 99.34 Very High Very High Very High
Morphine Dependence 4 99.08 Very High Very High Very High
Pain 7 98.80 Very High Very High Very High
Targeted Disruption 4 97.72 Very High Very High Very High
Thrombosis 38 93.52 High High
Nociception 5 85.92 High High
Ganglion Cysts 10 50.96 Quite High
Sprains And Strains 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to examine the effect of different PKC isoform inhibitors on sigma-1 receptor-mediated pain facilitation and increased spinal pNR1 expression in mice.
Spec (examine) Regulation (effect) of Spec (examine) Negative_regulation (inhibitors) of PKC in spinal associated with pain and kinase c
1) Confidence 0.43 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.25 Pain Relevance 0.78
By inducing morphine dependence in mice, changes in inositol phosphate contents, protein kinase C(PKC) activity in brain regions and effect of PKC inhibitor on the development of morphine dependence were investigated.
Regulation (effect) of Negative_regulation (inhibitor) of PKC in brain associated with addiction, kinase c and morphine
2) Confidence 0.27 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016940 Disease Relevance 0.20 Pain Relevance 0.60
Analysis of primary platelet adhesion to collagen, however, showed no effect of loss of either PKC?
Neg (no) Regulation (effect) of Negative_regulation (loss) of PKC in platelet associated with kinase c and adhesions
3) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.68 Pain Relevance 0.37
For this purpose, in this study we examined the effects of activators and inhibitors of PKA and PKC on the spontaneous augmentation of NaV1.9, using NaV1.8 knock-out (KO) mice [5,11,13] to record the NaV1.9 current in isolation.

2.

Spec (examined) Regulation (effects) of Spec (examined) Negative_regulation (inhibitors) of PKC associated with targeted disruption
4) Confidence 0.12 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0.15 Pain Relevance 0.21

General Comments

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