INT102890

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.41
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANG) DNA binding (ANG) extracellular space (ANG)
extracellular region (ANG) cell death (ANG) nucleolus (ANG)
Anatomy Link Frequency
heart 4
blood 1
platelets 1
epithelium 1
kidney 1
ANG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 100.00 Very High Very High Very High
metalloproteinase 2 65.52 Quite High
chemokine 2 59.76 Quite High
bradykinin 42 56.32 Quite High
antagonist 5 38.84 Quite Low
agonist 6 32.92 Quite Low
Enkephalin 5 25.00 Low Low
fibrosis 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 34 100.00 Very High Very High Very High
Hypertrophy 1 100.00 Very High Very High Very High
Pre-eclampsia 66 78.92 Quite High
Hypertension 44 50.00 Quite Low
Diabetes Mellitus 23 5.00 Very Low Very Low Very Low
Myocardial Infarction 22 5.00 Very Low Very Low Very Low
Obesity 10 5.00 Very Low Very Low Very Low
Renal Disease 8 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ang 1-7 was released (88% to 100%) by a metallopeptidase, as established with peptidase inhibitors.
Localization (released) of Ang
1) Confidence 0.72 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.03
Human heart tissue enzymes cleave angiotensin (Ang) I to release Ang 1-9, Ang II, or Ang 1-7.
Localization (release) of Ang in heart
2) Confidence 0.72 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0
Human heart tissue enzymes cleave angiotensin (Ang) I to release Ang 1-9, Ang II, or Ang 1-7.
Localization (release) of Ang in heart
3) Confidence 0.72 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0
Human heart tissue enzymes cleave angiotensin (Ang) I to release Ang 1-9, Ang II, or Ang 1-7.
Localization (release) of Ang in heart
4) Confidence 0.72 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0
Human heart tissue enzymes cleave angiotensin (Ang) I to release Ang 1-9, Ang II, or Ang 1-7.
Localization (release) of Ang in heart
5) Confidence 0.72 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0
In the rat, Ang-(1–7) and ACE2 localize in the primary and secondary decidual zone, and in the luminal and glandular epithelium.
Localization (localize) of Ang in epithelium
6) Confidence 0.43 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.07 Pain Relevance 0
The differences in tissue versus circulating concentrations of the various components of the RAS are highlighted by the fact that Ang-(1–7) is decreased in the blood of preeclamptic women[57].
Localization (decreased) of Ang in blood
7) Confidence 0.40 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.15 Pain Relevance 0.03
The binding of Ang II to its Type 1 receptors, besides mediating its main biologic effects, including vasoconstriction, cell proliferation, hypertrophy, and aldosterone secretion, provides feedback inhibition of further renin release by the kidney (Figure 1).
Localization (secretion) of Ang in kidney associated with hypertrophy and increased venous pressure under development
8) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.20 Pain Relevance 0
Using this technology we have previously shown that PDGF, angiogenin, RANTES, and many other cytokines and growth factors are secreted by platelets following thrombin activation [27].
Localization (secreted) of angiogenin in platelets associated with cytokine
9) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.20

General Comments

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