INT102891

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 30.57
Pain Relevance 5.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
heart 2
decidua 1
kidney 1
endothelial cells 1
monocyte 1
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
Inflammation 1040 99.82 Very High Very High Very High
TRP channel 19 98.68 Very High Very High Very High
cytokine 129 98.60 Very High Very High Very High
chemokine 67 98.04 Very High Very High Very High
Inflammatory mediators 51 95.88 Very High Very High Very High
adenocard 5 95.44 Very High Very High Very High
ischemia 36 93.76 High High
B1 receptor 91 91.44 High High
cINOD 43 91.08 High High
Disease Link Frequency Relevance Heat
Cancer 1448 99.96 Very High Very High Very High
INFLAMMATION 1118 99.82 Very High Very High Very High
Targeted Disruption 5 99.78 Very High Very High Very High
Disease 437 99.68 Very High Very High Very High
Stress 195 99.68 Very High Very High Very High
Pre-eclampsia 66 99.64 Very High Very High Very High
Hypoxia 206 99.26 Very High Very High Very High
Solid Tumor 56 98.56 Very High Very High Very High
Increased Venous Pressure Under Development 95 98.36 Very High Very High Very High
Diabetic Retinopathy 235 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations reveal for the first time that activation of AT1aR can trigger internalization and functional down-regulation of TRPV4, and the data uncover an entirely novel functional attribute for the heterodimerization between AT1aR and TRPV4.
Positive_regulation (activation) of AT1aR
1) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.07
The alternative basis under which induction of AT1 in tumours may occur is by looking at the environment under which the cancer is developing.
Positive_regulation (induction) of AT1 associated with cancer
2) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.83 Pain Relevance 0.05
AngII is demonstrated to promote migration and proliferation of smooth muscle cells, as well as production of extracellular matrix through AT1 activation.
Positive_regulation (activation) of AT1 in extracellular matrix
3) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.29 Pain Relevance 0.26
Significant evidence has been shown that AT1 receptors are upregulated during disease and that AT2 receptor expression follows behind AT1 expression during injury and healing.
Positive_regulation (upregulated) of AT1 associated with injury and disease
4) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.86 Pain Relevance 0.37
Hence, summarised in figure 1, the tumor environment thus offers both hypoxia and oxidative stress mechanisms for induction of AT1.
Positive_regulation (induction) of AT1 associated with stress, hypoxia and cancer
5) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.93 Pain Relevance 0.05
Systemically, therefore, what purpose does this upregulation of AT1 serve?
Positive_regulation (upregulation) of AT1
6) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.38 Pain Relevance 0.14
A single evolutionary step, however, upregulation of AT1 would provide a considerable advantage to cancer cells that have learnt to evade the apoptosis and growth regulatory effects of TGF-?.
Positive_regulation (upregulation) of AT1 associated with cancer and apoptosis
7) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.84 Pain Relevance 0.04
AT1 activation has also been shown to increase the activity of HIF-1?
Positive_regulation (activation) of AT1
8) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.30 Pain Relevance 0.03
Activation of AT1 also causes the expression of TGF-?
Positive_regulation (Activation) of AT1
9) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.87 Pain Relevance 0.20
Cancer is a systemic disease, one that can affect every part and organ in the body and, as presented in this review so far with regards to the role of AT1 in cancer, AT1 upregulation is of the utmost importance in the activation of inflammation.
Positive_regulation (upregulation) of AT1 in body associated with inflammation, cancer and disease
10) Confidence 0.57 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.51 Pain Relevance 0.23
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Positive_regulation (stimulation) of AT1 in heart associated with heart rate under development
11) Confidence 0.52 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.96 Pain Relevance 0.13
-arrestins with TRPV4 upon stimulation of AT1aR and the functional implications of this novel interaction.


Positive_regulation (stimulation) of AT1aR
12) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0.51 Pain Relevance 0.08
Moreover, B2R knockout mice have increased ANG II AT2R mRNA and protein expression that contributes to elevation of NO as compensatory protective mechanism in thrombosis [78].
Positive_regulation (increased) of AT2R associated with targeted disruption and thrombosis
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.24 Pain Relevance 0.38
The activation of AT1 (shown in figure 2) has a powerful pro-inflammatory effect [16], promoting the expression of many pro-inflammatory mediators, such as cytokines, chemokines and adhesion molecules through the activation of signalling pathways.
Positive_regulation (activation) of AT1 associated with chemokine, inflammatory mediators, inflammation, adhesions and cytokine
14) Confidence 0.44 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.05 Pain Relevance 0.27
Two mechanisms for upregulation of AT1 are discussed: 1) evolutionary changes to take advantage of this pro-inflammatory control mechanism, 2) AT1 expression induced by an alternating environment of hypoxia and oxidative stress.
Positive_regulation (upregulation) of AT1 associated with stress, inflammation and hypoxia
15) Confidence 0.44 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.61 Pain Relevance 0.51
The invasiveness and immunosuppression of many cancers appears dependent on inflammation and the upregulation of AT1.
Positive_regulation (upregulation) of AT1 associated with inflammation and cancer
16) Confidence 0.44 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.59 Pain Relevance 0.48
Most, if not all, solid tumours utilise inflammation processes, which, through the over-expression and activation of AT1 and the subsequent expression of a number of inflammatory cytokines and chemokines, allow for tumour protection from the immune system through immunosuppression, as well as tumour progression and metastasis.
Positive_regulation (activation) of AT1 in immune system associated with chemokine, inflammation, cancer, solid tumor, metastasis and cytokine
17) Confidence 0.44 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.36 Pain Relevance 0.48
-B; (3) upregulating angiotensin II type 1 receptor in vascular smooth muscle cells, and directly quenching the production of nitric oxide by endothelial cells [24, 25], resulting in increased production of endothelin-1 [26]; (4) elevation of von Willebrand factor [27], which is known to be associated with endothelial dysfunction.
Positive_regulation (upregulating) of angiotensin II type 1 receptor in endothelial cells
18) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975076 Disease Relevance 1.02 Pain Relevance 0.06
Herse et al., has found an upregulation of decidual AT1R mRNA in preeclampsia; in contrast, the vasodilator AT2 receptor gene expression is present in 4% of the preeclamptic versus 60% of controls[135,137].
Positive_regulation (upregulation) of AT1R associated with pre-eclampsia
19) Confidence 0.40 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.16 Pain Relevance 0.08
Immunoreactivities for angiotensinogen and AT1R are increased in chorionic villi and decidua of preeclamptic subjects, as compared to normal[135].
Positive_regulation (increased) of AT1R in decidua
20) Confidence 0.29 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.16 Pain Relevance 0.07

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