INT102894

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Context Info
Confidence 0.73
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.75
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
tail 1
Ankle 1
heart 1
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
antagonist 22 99.90 Very High Very High Very High
agonist 109 99.80 Very High Very High Very High
Onset of action 1 80.32 Quite High
headache 3 72.84 Quite High
Dopamine 1 69.92 Quite High
bradykinin 5 67.76 Quite High
Inflammation 2 58.08 Quite High
fibrosis 2 57.40 Quite High
imagery 7 29.52 Quite Low
Disease Link Frequency Relevance Heat
Hypertension 47 99.16 Very High Very High Very High
Pressure And Volume Under Development 21 94.20 High High
Cardiovascular Disease 14 88.96 High High
Myocardial Infarction 65 82.44 Quite High
Heart Rate Under Development 17 78.44 Quite High
Increased Venous Pressure Under Development 12 73.92 Quite High
Headache 3 72.84 Quite High
INFLAMMATION 3 58.08 Quite High
Fibrosis 2 57.40 Quite High
Apoptosis 4 41.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, we immunostained AT1aR and TRPV4 and examined the localization of these two proteins by confocal microscopy.
Spec (examined) Localization (localization) of AT1aR
1) Confidence 0.73 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
The degree of AT2 stimulation is proportional to the selectivity of AT1 blockade.12
Localization (selectivity) of AT1
2) Confidence 0.56 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.42 Pain Relevance 0.06
Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A.
Localization (release) of Angiotensin 1-9 and 1-7 in heart associated with enkephalin
3) Confidence 0.30 Published 2002 Journal Hypertension Section Title Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.16
Likewise, agonist-mediated internalization of the angiotensin II type 1A receptor (AT1AR) was not affected by Rab5 protein expression despite the formation of Rab5-AT1AR protein complexes mediated, at least in part, by the last 10 amino acid residues of the C-tail of AT1AR itself [37].
Localization (internalization) of AT1AR in tail associated with agonist
4) Confidence 0.26 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.12
Ankle edema encountered during calcium entry blockade is not due to renal fluid retention but involves a rise in intracapillary pressure (as a consequence of a selective diminution of the precapillary arteriolar tone), with an ensuing leak of fluid into the interstitium.22 Valsartan, like all ARBs, exhibits a placebo-like tolerability.8,17

Position of calcium antagonists and angiotensin receptor blockers in the treatment of hypertension

Localization (blockers) of angiotensin receptor in Ankle associated with pressure and volume under development, antagonist and hypertension
5) Confidence 0.16 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672450 Disease Relevance 1.33 Pain Relevance 0.40

General Comments

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